Hippocampal replay of experience at real-world speeds
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Abstract
Representations related to past experiences play a critical role in memory and decision-making processes. The rat hippocampus expresses these types of representations during sharp-wave ripple (SWR) events, and previous work identified a minority of SWRs that contain ‘replay’ of spatial trajectories at ∼20x the movement speed of the animal. Efforts to understand replay typically make multiple assumptions about which events to examine and what sorts of representations constitute replay. We therefore lack a clear understanding of both the prevalence and the range of representational dynamics associated with replay. Here, we develop a state space model that uses a combination of movement dynamics of different speeds to capture the spatial content and time evolution of replay during SWRs. Using this model, we find that the large majority of replay events contain spatially coherent, interpretable content. Furthermore, many events progress at real-world, rather than accelerated, movement speeds, consistent with actual experiences.
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Recent remodelling of sharp-wave-ripple events suggests that neuronal replay often occurs at 'real-world' speeds that reflect actual experience.
“recent remodelling of sharp-wave-ripple events suggests that this neuronal replay often occurs at ‘real-world’ speeds that reflect actual experience [185], as observed in other studies [127].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [185]
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References 81 · Cited by 89
Research works printed but not linked: 2
- Hagberg AA Schult DA Swart PJ Structure EN 2008 Dynamics, and function using NetworkX Proceedings of the 7th Python In Science Conference Pasadena 11 15
- Lam SK Pitrou A Seibert S 2015 Numba: a LLVM-Based Python JIT compiler Proceedings of the Second Workshop on the LLVM Compiler Infrastructure in HPC -LLVM ’15 Austin 1 6
- Authors
- Denovellis, E. L., Gillespie, A. K., Coulter, M. E., Sosa, M., Chung, J. E., Eden, U. T., & Frank, L. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of California, San Francisco (US)
- Stanford Medicine (US)
- Boston University (US)
- Corresponding author
- Frank, Loren M
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2021-09-27
- Volume
- 10
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC8476125
- OpenAlex
- W3202646677
- Cited by
- 89
- References
- 81
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 18 · 2023: 11 · 2022: 14 · 2021: 7
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Simons Foundation (542971, 542981)
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampal replay, sharp-wave ripples, spatial memory, movement speed, state-space model, rat hippocampus, memory consolidation, decision-making
- MeSH terms
- Memory Consolidation, Action Potentials, Animals, Behavior, Animal, Hippocampus, Male, Memory, Models, Neurological, Rats, Long-Evans, Rats
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