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Cited by 19Syphilis Diagnosis and TreatmentNeonatal and Maternal InfectionsHistorical Medical Research and Treatments

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Caracterización y seguimiento a 6 meses de una cohorte de recién nacidos con sífilis congénita

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Vallejo, Cristian, Cifuentes, Yolanda·2015·Biomédica
DOI 10.7705/biomedica.v36i1.2661
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Abstract

INTRODUCTION: Congenital syphilis is a preventable disease. However, the incidence in Colombia has increased and reached the figure of 3.28 cases per 1,000 live births in 2011. OBJECTIVE: To characterize newborns with congenital syphilis and describe follow-up over 6 months following their diagnosis and treatment. MATERIALS AND METHODS: Between August, 2011, and February, 2012, in Hospital La Victoria, sede Instituto Materno Infantil, newborns with congenital syphilis were identified and treated. Clinical and laboratory follow-up was carried out for six months until it was determined that the disease was cured. The analyzed variables included patients' clinical and laboratory characteristics. RESULTS: In this period, we identified 29 cases that met the criteria of congenital syphilis, with a frequency in the institution of one case per 69 births. There was one stillbirth and one neonatal death, four were premature, and five had growth restriction. Of the 28 live births, 15 were asymptomatic. There were two cases with neurosyphilis, representing 15% of symptomatic newborns. Follow-up was done on 18 out of 27 children (66.6%), including most symptomatic cases and the two cases of neurosyphilis. All cases showed the expected decrease in VDRL titers without clinical sequelae, meeting the criteria of being cured. CONCLUSIONS: A high incidence of the disease, failure to prevent it, varied expression in its presentation, and the effectiveness of treatment in the neonatal period were evidenced in this study.

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Metadata

Authors
Vallejo, C., & Cifuentes, Y.
Affiliations
Universidad Nacional de Colombia (CO)
Venue
Biomédica
Publisher
Instituto Nacional de Salud (Colombia)
Published
2015-08-24
Volume
36
Issue
1
Pages
101-8
ISSN
0120-4157 (ISSN-L)
DOI
10.7705/biomedica.v36i1.2661
OpenAlex
W1498246701
Cited by
11
References
24
Citations by year
2025: 2 · 2024: 2 · 2022: 2 · 2020: 2 · 2019: 1 · 2017: 2
FWCI
0.49
Type
journal article
Language
es
Open access
Locations
  • Biomédica (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
Keywords
congenital syphilis, neonates, neurosyphilis, VDRL titers, syphilis treatment, follow-up, stillbirth, neonatal death, growth restriction, Colombia
MeSH terms
Colombia, Female, Fetal Growth Retardation, Follow-Up Studies, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Neurosyphilis, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Prospective Studies, Syphilis Serodiagnosis, Syphilis, Congenital, Incidence, Stillbirth

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