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An Integrative Approach of Neeli Bhringraj Polyherbal Hair Oil in Clinical Evaluation of Androgenetic Alopecia (Khalitya) and Premature Hair Graying (Pālitya): A Randomized, Double-Blind Clinical Study

Patel, Maheshvari N, Patel, Nayan, Merja, Apeksha, Patel, Ravikumar R, Mishra, Manisha·2026·Cureus
DOI 10.7759/cureus.111988
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Research works printed but not linked: 23

  1. Cash TF. The psychological effects of androgenetic alopecia in men. J Am Acad Dermatol. 1992, 6:926-931. 10.1016/0190-9622(92)70134-2 · DOI · Paper page
  2. Hunt N, McHale S. The psychological impact of alopecia. BMJ. 2005, 331:951-953. 10.1136/bmj.331.7522.951 · DOI · Paper page
  3. Trüeb RM. Molecular mechanisms of androgenetic alopecia. Exp Gerontol. 2002, 37:981-990. 10.1016/s0531-5565(02)00093-1 · DOI · Paper page
  4. Malkud S. Telogen effluvium: a review. J Clin Diagn Res. 2015, 9:WE01-WE03. 10.7860/JCDR/2015/15219.6492 · doi:10.7860/jcdr/2015/15219.6492
  5. Ong MM, Avram M, McMichael A, Tosti A, Lipner SR. Antiandrogen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies. J Am Acad Dermatol. 2025, 93:749-760. 10.1016/j.jaad.2025.04.074 · doi:10.1016/j.jaad.2025.04.074
  6. Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov. 2012, 6:130-136. 10.2174/187221312800166859 · DOI · Paper page
  7. Suchonwanit P, Thammarucha S, Leerunyakul K. Minoxidil and its use in hair disorders: a review. Drug Des Devel Ther. 2019, 13:2777-2786. 10.2147/DDDT.S214907 · DOI · Paper page
  8. Faghihi G, Iraji F, Siadat AH, Saber M, Jelvan M, Hoseyni MS. Comparison between "5% minoxidil plus 2% flutamide" solution vs. "5% minoxidil" solution in the treatment of androgenetic alopecia. J Cosmet Dermatol. 2022, 21:4447-4453. 10.1111/jocd.14788 · DOI
  9. Jha U, Singh K, Singh A. Phytochemical and pharmacology activity of bhringraj: a review. Int J Health Sci. 2022, 6:11113-11125. 10.53730/ijhs.v6nS3.8560 · doi:10.53730/ijhs.v6ns3.8560
  10. Verma SM, Suresh KB. Phytochemical investivations of indigofera tinctoria linn leaves. Anc Sci Life. 2002, 21:235-239.
  11. Badhe N, Shirode L, Lale S. Formulation and evaluation of herbal hair tonic. Res J Top Cosmet Sci. 2015, 6:86-90. 10.5958/2321-5844.2015.00012.6 · DOI
  12. Karole S, Shrivastava S, Thomas S, et al.. Polyherbal formulation concept for synergic action: a review. J Drug Deliv Ther. 2019, 9:453-466. 10.22270/jddt.v9i1-s.2339 · DOI
  13. Pandey A, Tripathi S. Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug. J Pharmacogn Phytochem. 2014, 2:115-119.
  14. Patel MN, Patel N, Merja A. Advancing hair regrowth assessment: development and standardization of methods for evaluating new hair growth, hair keratin levels, and scalp health in androgenetic alopecia patients. Cureus. 2025, 17:e79859. 10.7759/cureus.79859 · doi:10.7759/cureus.79859
  15. Patel M, Tuli N, Patel N, Merja A. A clinical evaluation of the safety, efficacy, and tolerability of the soulflower rosemary redensyl hair growth serum, Tetragain™, in healthy female subjects for the treatment of alopecia: promoting hair growth and reducing gray hair. Cureus. 2025, 17:e77066. 10.7759/cureus.77066 · DOI
  16. Singal A, Daulatabad D, Grover C. Graying severity score: a useful tool for evaluation of premature canities. Indian Dermatol Online J. 2016, 7:164-167. 10.4103/2229-5178.182372 · doi:10.4103/2229-5178.182372
  17. Patel M, Patel NK, Merja A. Validation-standardization methods-evaluators testing of hair care range of products. Paripex Indian J Res. 2023, 12:
  18. Patel MN, Patel NK, Merja AM, Gajera DU, Purani AK, Pandya JH. Methodology validation: correlating adherent Scalp Flaking Score (ASFS) with phototrichogram for scalp dandruff evaluation in adult subjects. Cureus. 2024, 16:e63247. 10.7759/cureus.63247 · DOI
  19. Kaliyadan F, Gosai BB, Al Melhim WN, Feroze K, Qureshi HA, Ibrahim S, Kuruvilla J. Scanning electron microscopy study of hair shaft damage secondary to cosmetic treatments of the hair. Int J Trichology. 2016, 8:94-98. 10.4103/0974-7753.188035 · doi:10.4103/0974-7753.188035
  20. Patel M, Patel N, Merja A, Patel RR. Protective effects of Neeli Bhringraj oil against hair breakage and strengthening damaged hair fibers: scientific evidence from an in-vitro fatigue test model. J Pharmacol Genet Mol Biol. 2025, 1:171-179.
  21. Datta K, Singh AT, Mukherjee A, Bhat B, Ramesh B, Burman AC. Eclipta alba extract with potential for hair growth promoting activity. J Ethnopharmacol. 2009, 124:450-456. 10.1016/j.jep.2009.05.023 · DOI · Paper page
  22. Vanderveen EE, Ellis CN, Kang S, Case P, Headington JT, Voorhees JJ, Swanson NA. Topical minoxidil for hair regrowth. J Am Acad Dermatol. 1984, 11:416-421. 10.1016/s0190-9622(84)70183-6 · doi:10.1016/s0190-9622(84)70183-6
  23. Penha MA, Miot HA, Kasprzak M, Müller Ramos P. Oral minoxidil vs topical minoxidil for male androgenetic alopecia: a randomized clinical trial. JAMA Dermatol. 2024, 160:600-605. 10.1001/jamadermatol.2024.0284 · doi:10.1001/jamadermatol.2024.0284

Metadata

Authors
Patel, M. N., Patel, N., Merja, A., Patel, R. R., & Mishra, M.
Venue
Cureus
Publisher
Springer Science and Business Media LLC
Published
2026-07-03
ISSN
2168-8184
DOI
10.7759/cureus.111988
Cited by
0
Language
en

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CoChat. (2026). Citation check: An Integrative Approach of Neeli Bhringraj Polyherbal Hair Oil in Clinical Evaluation of Androgenetic Alopecia (Khalitya) and Premature Hair Graying (Pālitya): A Randomized, Double-Blind Clinical Study. https://app.cochat.ai/papers/10.7759/cureus.111988
The paper
Patel, M. N., Patel, N., Merja, A., Patel, R. R., & Mishra, M. (2026). An Integrative Approach of Neeli Bhringraj Polyherbal Hair Oil in Clinical Evaluation of Androgenetic Alopecia (Khalitya) and Premature Hair Graying (Pālitya): A Randomized, Double-Blind Clinical Study. Cureus. https://doi.org/10.7759/cureus.111988

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