Hypothalamic Injury Following Surgery for Craniopharyngioma Causing Immediate Postoperative Death
Open accessAbstract
While autonomic disturbances resulting from a hypothalamic injury are uncommon complications following surgery for craniopharyngioma, they can lead to postoperative death. Herein, we discuss the case of a multicompartmental craniopharyngioma in a 13-year-old child who died due to unexpected hypothalamic injury, resulting in rapid deterioration in the hemodynamic and neurological status of the patient.
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In individuals with hypothalamic syndrome with multiple pituitary hormone deficiencies (AVP-D, AI), autonomic impairment is a further risk factor for possible life-threatening complications from stresses.
“In individuals with hypothalamic syndrome with multiple pituitary hormone deficiencies (AVP-D, AI) that confer vulnerability to dehydration and hypotension, autonomic impairment is a further risk factor for possible life-threatening complications from stresses (61).”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [61]
The Discussion attributes ventricular failure and death in a postoperative patient to injury of the hypothalamus’s autonomic region; the Case presentation also documents diabetes insipidus and blood-pressure fluctuations. This supports the possibility of life-threatening complications from autonomic impairment, but the paper does not establish the claimed risk in people with both AVP-D and adrenal insufficiency, or from stresses generally. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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Cites
Karavitaki, N., Cudlip, S., Adams, C. B. T., & Wass, J. A. H. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0002 · Cited by 514 · see citing works
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- [2]Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome Neurosurgery Weiner HL Wisoff JH Rosenberg ME 1001 1010 35 1994 7885544
- [3]Results after treatment of craniopharyngiomas: further experiences with 73 patients since 1997 J Neurosurg Hofmann BM Höllig A Strauss C Buslei R Buchfelder M Fahlbusch R 373 384 116 2012 https://doi.org/10.3171/2011.6.JNS081451 21942724 · DOI
- [4]Aggressive surgery based on an anatomical subclassification of craniopharyngiomas Neurosurg Focus Morisako H Goto T Goto H Bohoun CA Tamrakar S Ohata K 0 41 2016 27903115
- [5]A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma Childs Nerv Syst Clark AJ Cage TA Aranda D Parsa AT Sun PP Auguste KI Gupta N 231 238 29 2013 https://doi.org/10.1007/s00381-012-1926-2. 23089933 · DOI
- [6]Radiotherapy, especially at young age, increases the risk for de novo brain tumors in patients treated for pituitary/sellar lesions J Clin Endocrinol Metab Burman P van Beek AP Biller BM Camacho-Hübner C Mattsson AF 1051 1058 102 2017 https://doi.org/10.1210/jc.2016-3402. 28359095 · DOI
- [7]High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma Clin Endocrinol (Oxf) Pereira AM Schmid EM Schutte PJ 197 204 62 2005 15670196
- [8]Craniopharyngioma: a comparison of tumor control with various treatment strategies Neurosurg Focus Yang I Sughrue ME Rutkowski MJ 0 28 2010 https://doi.org/10.3171/2010.1.FOCUS09307 20367362 · DOI
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Approach to the patient with acquired hypothalamic syndrome
Grishman, E. K., & McCormack, S. E. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag197
- Authors
- Bhandari, P., Nagpal, S., Parthasarathi, A., Ahmed, M. M., & Jeswani, M.
- Affiliations
- Erie County Medical Center (US)
- Corresponding author
- Jeswani, Mayank
- Venue
- Cureus
- Published
- 2021-10-16
- Volume
- 13
- Issue
- 10
- Pages
- e18814-e18814
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC8591369
- OpenAlex
- W3207299293
- Cited by
- 1
- References
- 1
- Citations by year
- 2022: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- craniopharyngioma, hypothalamic injury, postoperative mortality, autonomic dysfunction, pediatric neurosurgery, surgical complications, hemodynamic instability
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