Fatal Acute Disseminated Encephalomyelitis Post-COVID-19 Vaccination: A Rare Case Report
Open accessAbstract
Acute disseminated encephalomyelitis (ADEM) is a disease of the brain and spinal cord that is an immune-mediated inflammatory and demyelinating disorder, which is commonly preceded by an infection. Some reports have also shown the association of acute demyelination of the central nervous system (CNS) with vaccination. Primarily, the involvement of the white matter of the cerebral hemispheres, brain stem, and spinal cord is observed. Such lesions should be considered as the differentials of ADEM. We would like to report a case of a 77-year-old female who was of post-COVID-19 vaccination status and presented to us with altered sensorium with imaging revealing acute demyelination.
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Although some case reports have suggested a possible association between COVID-19 vaccination and ADEM, there was no consistent pattern in terms of vaccine or timing following vaccination, and larger epidemiological studies have not confirmed any potential association.
“Although some case reports have suggested a possible association between COVID-19 vaccination and ADEM, there was no consistent pattern in terms of vaccine or timing following vaccination, and larger epidemiological studies have not confirmed any potential association [41 -44].”
From COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals (2024) · cites this paper as [42]
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Acute disseminated encephalomyelitis (ADEM) following recent Oxford/AstraZeneca COVID-19 vaccination
Permezel, F., Borojevic, B., Lau, S., & de Boer, H. H. (2022) · Forensic Science, Medicine and Pathology · doi:10.1007/s12024-021-00440-7 · Cited by 62 · see citing works
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Faksova, K., Walsh, D., Jiang, Y., Griffin, J., Phillips, A., Gentile, A., Kwong, J. C., Macartney, K., Naus, M., Grange, Z., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.01.100 · Cited by 212 · see citing works
- Authors
- Nimkar, S. V., Yelne, P., Gaidhane, S. A., Kumar, S., Acharya, S., & Gemnani, R. R.
- Affiliations
- Jawaharlal Nehru Medical College (IN)
- Corresponding author
- Nimkar, Shubham V
- Venue
- Cureus
- Published
- 2022-11-22
- Volume
- 14
- Issue
- 11
- Pages
- e31810-e31810
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC9788800
- OpenAlex
- W4309713448
- Cited by
- 6
- References
- 1
- Citations by year
- 2024: 3 · 2023: 3
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- acute disseminated encephalomyelitis, COVID-19 vaccination, vaccine adverse events, demyelination, central nervous system demyelination, altered sensorium, elderly patients
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