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Navigating the Complexities of Laryngeal Tuberculosis: A Comprehensive Case Report and Literature Review
Open accessAbstract
This case report and literature review presents a detailed exploration of the diagnosis and management of laryngeal tuberculosis, emphasizing the challenges encountered in dealing with rare and multifaceted medical conditions. Through a systematic analysis of the patient's clinical journey and an insightful review of pertinent literature, the study underscores the complexity inherent in diagnosing primary laryngeal tuberculosis and highlights the growing relevance of this rare extrapulmonary manifestation. The case showcases the significance of a comprehensive diagnostic approach, the collaboration of diverse medical specialists, adherence to established treatment guidelines, and the crucial role of continuous patient monitoring. The successful resolution of this intricate case serves as a compelling testament to the power of interdisciplinary coordination and precision medicine, providing valuable insights into navigating the intricate landscape of laryngeal tuberculosis.
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“The clinical presentation of laryngeal TB is non-specific, often displaying the characteristics of laryngeal carcinoma due to similar symptoms and laryngoscopic findings, such as ulcerations and mass-like lesions [40].”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This condition is a form of EPTB that affects less than 1% of all TB cases, often leading to misdiagnosis and delayed treatment.”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [40]
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Research works printed but not linked: 12
- Cole AE, Heaton D, Chekairi A. Laryngeal tuberculosis: a rare cause of critical airway obstruction. BMJ Case Rep. 2018, 2018:10.1136/bcr-2017-222841 · DOI
- Al-Mutairi D, Kilty SJ. Bacterial biofilms and the pathophysiology of chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2011, 11:18-23. 10.1097/ACI.0b013e3283423376 · DOI
- Wang CC, Lin CC, Wang CP, Liu SA, Jiang RS. Laryngeal tuberculosis: a review of 26 cases. Otolaryngol Head Neck Surg. 2007, 137:582-8. 10.1016/j.otohns.2007.04.002 · DOI
- Matimba A, Moncho M, Musoke J, Seedat RY. Diagnosis of laryngeal tuberculosis in a high TB burden area. Eur Arch Otorhinolaryngol. 2020, 277:2137-40. 10.1007/s00405-020-05976-y · DOI
- Raj R, Sud P, Saharan N, Virk RS. Laryngeal tuberculosis: a neglected diagnosis. BMJ Case Rep. 2022, 15:10.1136/bcr-2021-248095 · DOI
- Yin N, Delord M, Giovanni A, del Grande J, Drancourt M, Brouqui P, Lagier JC. Laryngeal tuberculosis diagnosed by stool sample cultures: a case report. J Med Case Rep. 2015, 9:74. 10.1186/s13256-015-0548-1 · DOI
- Sengupta A, Saha K, Jash D, Banerjee SN, Biswas G, Mitra SK. Laryngeal tuberculosis: current status in India and the world. J Indian Med Assoc. 2006, 104:292-4.
- Tazin F, Kumar H, Israr MA, Omoleye D, Orlang V. Li-Fraumeni syndrome: a rare genetic disorder. Cureus. 2022, 14:e29240. 10.7759/cureus.29240 · DOI
- Smulders YE, De Bondt BJ, Lacko M, Hodge JA, Kross KW. Laryngeal tuberculosis presenting as a supraglottic carcinoma: a case report and review of the literature. J Med Case Rep. 2009, 3:9288. 10.1186/1752-1947-3-9288 · DOI
- Sandage MJ, Milstein CF, Nauman E. Inducible laryngeal obstruction differential diagnosis in adolescents and adults: a tutorial. Am J Speech Lang Pathol. 2023, 32:1-17. 10.1044/2022_AJSLP-22-00187 · DOI
- O'Kane AM, Jackson CP, Mahadevan M, Barber C. Laryngeal manifestations of pachyonychia congenita: a clinical case and discussion on management for the otolaryngologist. J Laryngol Otol. 2017, 131:S53-6. 10.1017/S0022215116008264 · DOI
- El Ayoubi F, Chariba I, El Ayoubi A, Chariba S, Essakalli L. Primary tuberculosis of the larynx. Eur Ann Otorhinolaryngol Head Neck Dis. 2014, 131:361-4. 10.1016/j.anorl.2013.10.005 · DOI
Cited by
Sorted by citations
Mogoantă, C. A., Osman, A., Georgescu, A.-M., Mitroi, A. M., Busuioc, C. I., Tănase, I., Cioboată, R., Liliac, I. M., Cimpeanu, O. L., & Ciolofan, M. S. (2025) · Pathogens · doi:10.3390/pathogens14050479 · Cited by 2
“The clinical presentation of laryngeal TB is non-specific, often displaying the characteristics of laryngeal carcinoma due to similar symptoms and laryngoscopic findings, such as ulcerations and mass-like lesions [40].”
Metadata
- Authors
- Gautam, A., Kumar, H., Gapizov, A., Paudel, P., & Gautam, R.
- Affiliations
- Dow University of Health Sciences (PK)
- Corresponding author
- Kumar, Harendra
- Venue
- Cureus
- Published
- 2023-10-04
- Volume
- 15
- Issue
- 10
- Pages
- e46505-e46505
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC10624933
- OpenAlex
- W4387371171
- Cited by
- 4
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- laryngeal tuberculosis, extrapulmonary tuberculosis, diagnosis, multidisciplinary management, multidisciplinary care, patient monitoring, medication adherence
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