Cited by 576Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative Diseases

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Drug treatments in Alzheimer’s disease

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Briggs, Robert, Kennelly, Sean P, O’Neill, Desmond·2016·Clinical Medicine

DOI 10.7861/clinmedicine.16-3-247PMC PMC5922703

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Abstract

Despite the significant public health issue that it poses, only five medical treatments have been approved for Alzheimer's disease (AD) and these act to control symptoms rather than alter the course of the disease. Studies of potential disease-modifying therapy have generally been undertaken in patients with clinically detectable disease, yet evidence suggests that the pathological changes associated with AD begin several years before this. It is possible that pharmacological therapy may be beneficial in this pre-clinical stage before the neurodegenerative process is established. Techniques providing earlier diagnosis, such as cerebrospinal fluid biomarkers and amyloid positron emission tomography neuroimaging, are key to testing this theory in clinical trials. Recent results from trials of agents such as aducanumab are encouraging but must also be interpreted with caution. Such medicines could potentially delay the onset of dementia and would therefore markedly reduce its prevalence. However, we currently remain a good distance away from clinically available disease-modifying therapy.

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BindingDB Entry 50010640: Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents.
BindingDB (2021) · UC San Diego · doi:10.7270/q2833wkn
BindingDB Entry 50002429: The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
BindingDB (2020) · UC San Diego · doi:10.7270/q2w95ct0
BindingDB Entry 50011500: Recent developments of small molecule γ-secretase modulators for Alzheimer's disease.
BindingDB (2022) · UC San Diego · doi:10.7270/q2v69p6t

Authors: Briggs, R., Kennelly, S. P., & O’Neill, D.
Affiliations: Tallaght University Hospital (IE)
ORCID: Briggs, Robert
O’Neill, Desmond
Venue: Clinical Medicine
Publisher: Elsevier BV
Published: 2016-06
Volume: 16
Issue: 3
Pages: 247-253
ISSN: 1470-2118 (ISSN-L)
DOI: 10.7861/clinmedicine.16-3-247
PMC: PMC5922703
OpenAlex: W2415242066
Cited by: 571
References: 76
Citations by year: 2026: 37 · 2025: 67 · 2024: 97 · 2023: 79 · 2022: 106 · 2021: 95 · 2020: 55 · 2019: 18 · 2018: 5 · 2017: 9 · 2016: 2
FWCI: 9.13
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 2872 d)
Locations: Clinical Medicine (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: Alzheimer's disease, pharmacotherapy, disease-modifying therapy, symptomatic treatment, preclinical Alzheimer's disease, cerebrospinal fluid biomarkers, amyloid PET, aducanumab, early diagnosis, dementia prevention
MeSH terms: Alzheimer Disease, Amyloid, Cholinesterase Inhibitors, Humans, Neuroprotective Agents

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