The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An update on allergen immunotherapy
Open accessAbstract
Allergen-specific immunotherapy (AIT) has been used to treat allergic diseases for over a century. It is the only treatment that addresses immune dysfunction underlying allergic responses rather than simply treating symptoms or suppressing inflammation. Its safety and efficacy in allergic rhinitis, asthma and insect allergy has been documented in a number of systematic reviews but its cost effectiveness is less clear. AIT reduces symptoms and requirement for medication, while improving quality of life. Further, the effect continues for years after discontinuation of treatment. However, evidence regarding cost effectiveness is limited. During AIT, allergen extracts are administered through a subcutaneous or sublingual route for 3-5 years. Subcutaneous immunotherapy is more effective in inducing long-term remission but systemic reactions do occur occasionally. Sublingual immunotherapy is safer and more convenient for the patient but evidence regarding its long-term efficacy is patchy. AIT is used widely in western Europe and the USA. In the UK, subcutaneous immunotherapy is often used for bee and wasp allergy, while both subcutaneous and sublingual immunotherapies are used for severe allergic rhinitis and occasionally for house dust mite and pet allergies. In conclusion, AIT is safe and effective and should be considered as a treatment option for those with allergic diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Allergen-specific immunotherapy (ASIT) represents an effective treatment for IgE-mediated allergies, including subcutaneous immunotherapy (SCIT), sublingual immunotherapy (SLIT), and intralymphatic immunotherapy (ILIT) (Figure 2f).”
From Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control (2025) · cites this paper as [159]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Allergen immunotherapy: A practice parameter third update
Cox, L., Nelson, H., Lockey, R., Calabria, C., Chacko, T., Finegold, I., Nelson, M., Weber, R., Bernstein, D. I., Blessing-Moore, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.034 · Cited by 1,256
Flagged first, then by citations
Research works printed but not linked: 21
- Lee, 2003, Allergy: the unmet need, Clin Med, 3, 303, 10.7861/clinmedicine.3-4-303 · DOI
- Walker, 2011, Immunotherapy for allergic rhinitis, Clin Exp Allergy, 41, 1177, 10.1111/j.1365-2222.2011.03794.x · DOI
- Tabar, 2005, Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoides pteronyssinus, J Allergy Clin Immunol, 116, 109, 10.1016/j.jaci.2005.05.005 · DOI
- Canonica, 2014, Sublingual immunotherapy: World Allergy Organization position paper 2013 update, World Allergy Organ J, 7, 6, 10.1186/1939-4551-7-6 · DOI
- Epstein, 2014, AAAAI/ACAAI surveillance study of subcutaneous immunotherapy, years 2008–2012: an update on fatal and nonfatal systemic allergic reactions, J Allergy Clin Immunol Pract, 2, 161, 10.1016/j.jaip.2014.01.004 · DOI
- Cox, 2006, Sublingual immunotherapy: a comprehensive review, J Allergy Clin Immunol, 117, 1021, 10.1016/j.jaci.2006.02.040 · DOI
- Jutel, 2015, International consensus on allergy immunotherapy, J Allergy Clin Immunol, 136, 556, 10.1016/j.jaci.2015.04.047 · DOI
- Durham, 1999, Long-Term clinical efficacy of grass-pollen immunotherapy, N Engl J Med, 341, 468, 10.1056/NEJM199908123410702 · DOI
- Des Roches, 1996, Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. V. Duration of the efficacy of immunotherapy after its cessation, Allergy, 51, 430
- Marogna, 2010, Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study, J Allergy Clin Immunol, 126, 969, 10.1016/j.jaci.2010.08.030 · DOI
- Berto, 2008, Economic studies of immunotherapy: a review, Curr Opin Allergy Clin Immunol, 8, 585, 10.1097/ACI.0b013e32831411e9 · DOI
- Nelson, 2009, Multiallergen immunotherapy for allergic rhinitis and asthma, J Allergy Clin Immunol, 123, 763, 10.1016/j.jaci.2008.12.013 · DOI
- Shamji, 2011, Mechanisms of immunotherapy to aeroallergens, Clin Exp Allergy, 41, 1235, 10.1111/j.1365-2222.2011.03804.x · DOI
- Drachenberg, 2001, A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections, Allergy, 56, 498, 10.1034/j.1398-9995.2001.056006498.x · DOI
- Gawchik, 2009, Pollinex Quattro Tree: allergy vaccine, Expert Opin Biol Ther, 9, 377, 10.1517/14712590802699596 · DOI
- Rosewich, 2013, Pollinex Quattro: an innovative four injections immunotherapy in allergic rhinitis, Hum Vaccin Immunother, 9, 1523, 10.4161/hv.24631 · DOI
- Abramson, 2010, Injection allergen immunotherapy for asthma, Cochrane Database Syst Rev
- Bae, 2013, Efficacy of allergen-specific immunotherapy for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials, J Allergy Clin Immunol, 132, 110, 10.1016/j.jaci.2013.02.044 · DOI · Paper page
- Boyle, 2012, Venom immunotherapy for preventing allergic reactions to insect stings, Cochrane Database Syst Rev
- Wood, 2016, Food allergen immunotherapy: current status and prospects for the future, J Allergy Clin Immunol, 137, 973, 10.1016/j.jaci.2016.01.001 · DOI
- Zolkipli, 2015, Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood, J Allergy Clin Immunol, 136, 1541, 10.1016/j.jaci.2015.04.045 · DOI
Cited by
Sorted by citations
Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control
Jiang, Y., Tian, X., Fu, X., Ma, B., Wang, Z., Han, B., Tao, H., Wang, J., & Wang, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210913 · Cited by 3
Metadata
- Authors
- Arshad, S. H.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- Arshad, S Hasan
- ORCID
- Arshad, S Hasan
- Venue
- Clinical Medicine
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 16
- Issue
- 6
- Pages
- 584-587
- ISSN
- 1470-2118 (ISSN-L)
- PMC
- PMC6297333
- OpenAlex
- W2559817904
- Cited by
- 13
- References
- 1
- Citations by year
- 2025: 2 · 2024: 4 · 2022: 1 · 2019: 2 · 2018: 1 · 2017: 3
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Medicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- allergen immunotherapy, subcutaneous immunotherapy, sublingual immunotherapy, allergic rhinitis, asthma, insect allergy, house dust mite allergy, pet allergy, cost-effectiveness, systemic reactions, long-term remission, quality of life
- MeSH terms
- Administration, Sublingual, Desensitization, Immunologic, Humans, Injections, Subcutaneous
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
