The biological role of UVB-induced cutaneous immunosuppression
Open accessAbstract
Skin is a large organ which protects our inner body from external stresses. Skin serves not only as a physical barrier but also as an important immune system. Ultraviolet rays B (UVB) activate melanin synthesis by melanocytes in the skin. Melanin, in turn, absorbs UVB and protects the skin from overexposure to UVB. In addition, it is generally known that UVB suppresses immune reaction in the skin. This phenomenon is applied to the treatment of cutaneous diseases such as psoriasis and vitiligo. UVB-induced immunosuppression is mediated by regulatory T cells (Tregs). We and other groups have figured out the mechanism of UVB-induced antigen specific immunosuppression. Here we propose that the role of UVB-mediated immunosuppression is the inhibition of self-destruction against external stresses.
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Narrow band UVB induce repigmentation in vitiligo by inhibition of self-destruction against external stresses.
“In therapeutical applications, the narrow band UVB induce repigmentation in vitiligo by inhibition of self-destruction against external stresses [120]”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [120]
The English summary (p. 7) says UVB-induced immunosuppression is applied to vitiligo treatment and proposes that UVB-mediated immunosuppression inhibits self-destruction against external stresses. It also says UVB stimulates melanin synthesis, but does not identify narrow-band UVB, establish repigmentation in vitiligo, or link the proposed inhibition of self-destruction to repigmentation. (LLM, conf=0.88)
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Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works
- Authors
- YOSHIKI, R., NAKAMURA, M., & TOKURA, Y.
- Affiliations
- University of Occupational and Environmental Health Japan (JP)
- Hamamatsu University School of Medicine (JP)
- Venue
- Journal of UOEH
- Published
- 2012
- Volume
- 34
- Issue
- 1
- Pages
- 77-83
- ISSN
- 0387-821X (ISSN-L)
- 2187-2864
- OpenAlex
- W2419128885
- Cited by
- 7
- References
- 0
- Citations by year
- 2024: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2013: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of UOEH (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- UVB-induced immunosuppression, melanogenesis, melanocytes, regulatory T cells, antigen-specific immunosuppression, psoriasis, vitiligo, skin as immune organ
- MeSH terms
- Animals, Humans, Immunosuppression Therapy, Melanins, Skin, Ultraviolet Rays
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