Voxel-level segmentation of pathologically-proven Adrenocortical carcinoma with Ki-67 expression (Adrenal-ACC-Ki67-Seg)

Abstract

Adrenocortical carcinoma (ACC) is a rare tumor of the adrenal cortex with a reported annual incidence of one case per million population. ACC is highly aggressive, highly fatal tumor with 5-year overall survival rates ranging from 14% to 44%. Diagnosis of ACC is primarily based on histopathological parameters from resected tumors, which include Ki-67. The Ki-67 index is one of the most important established prognostic markers for local recurrence of ACC. Radiomic feature extraction showed a significant association between radiomic signature and Ki-67 expression status in ACC. This retrospectively acquired data includes contrast enhanced CT imaging studies of 53 confirmed ACC patients between 2006 to 2018 with available clinical, pathological data includes Ki-67 index. Semi-automatic segmentation of the adrenal tumor created using AMIRA, then manually refined by experienced radiologist. The segmentations of each contrast-enhanced CT were done for purpose of radiomic features extraction.