The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Combined Medication with Stimulants and Non-stimulants for Attention-deficit/hyperactivity Disorder
Open accessAbstract
OBJECTIVE: To study the efficiency and indication of combined medication with a stimulant and non-stimulant for attention-deficiency/hyperactivity disorder (ADHD), herein, the authors examined children and adult patients with ADHD. METHODS: Subjects included patients diagnosed with ADHD who paid two or more visits to the outpatient clinic of the Kyung Hee University hospital from January 2009 to December 2019. The authors examined the age, sex, drugs, treatment adherence, and reason for combined medication. The subjects were classified into four groups: treatment with a non-stimulant (atomoxetine) only (Group ATX), treatment with a stimulant (methylphenidate immediate-release, extended-release, or osmotic-release oral system) only (Group MPH), exposed to both but separately used (Group SEP), and exposed to both with combined use (Group COM). The patient was considered adherent to treatment (1) on visiting the hospital ten or more times or consecutively for six months, and (2) medication possession ratio ≥ 0.8. RESULTS: Of 929 patients, 229 (24.7%) were female. Group ATX comprised 146 (15.7%) patients, Group MPH comprised 627 (67.5%) patients, Group SEP comprised 106 (11.4%) patients, and Group COM comprised 50 (5.4%) patients. Longer-term adherence was seen with combined medication and in females than with monopharmacy and in males. The main indication for combination was dose-limiting untoward effects. CONCLUSION: These results suggest that combined medication would facilitate treatment adherence for ADHD. Further research is essential for the replication of these results in a large sample and the investigation of the indications for administering combined medication in children and adults with ADHD.
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“non-stimulant medications like atomoxetine are frequently preferred despite the potential advantages offered by long-acting prescription stimulants [72,73].”
From Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review (2024) · cites this paper as [73]
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Subcommittee on Attention-Deficit/Hyperactivity Disorder, S. C. O. Q. I. A. M. (2011) · Pediatrics · doi:10.1542/peds.2011-2654 · Cited by 2,185
Medication treatment strategies in the MTA Study: relevance to clinicians and researchers
GREENHILL, L. L., ABIKOFF, H. B., ARNOLD, L. E., CANTWELL, D. P., CONNERS, C. K., ELLIOTT, G., HECHTMAN, L., HINSHAW, S. P., HOZA, B., JENSEN, P. S., et al. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199610000-00017 · Cited by 297
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Combination pharmacotherapy for adult ADHD
Adler, L. A., Reingold, L. S., Morrill, M. I., & Wilens, T. E. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0044-9 · Cited by 51
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Bahji, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13040999 · Cited by 83
“In such cases, non-stimulant medications like atomoxetine are frequently preferred despite the potential advantages offered by long-acting prescription stimulants [72,73].”
Background
Metadata
- Authors
- Bahn, G. H., & Seo, K.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Bahn, Geon Ho
- Venue
- Clinical Psychopharmacology and Neuroscience
- Published
- 2021-11-30
- Volume
- 19
- Issue
- 4
- Pages
- 705-711
- ISSN
- 1738-1088 (ISSN-L)
- 2093-4327
- PMC
- PMC8553528
- OpenAlex
- W3210426181
- Cited by
- 8
- References
- 25
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Clinical Psychopharmacology and Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Keywords
- attention deficit hyperactivity disorder, stimulants, atomoxetine, methylphenidate, medication adherence, medication possession ratio
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