Steinmetz, Michel O.

Tracking the ends: a dynamic protein network controls the fate of microtubule tips

Akhmanova, A., & Steinmetz, M. O. (2008) · Nature Reviews Molecular Cell Biology

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 1,047

Control of microtubule organization and dynamics: Two ends in the limelight

Akhmanova, A., & Steinmetz, M. O. (2015) · Nature Reviews Molecular Cell Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 895

An EB1-binding motif acts as a microtubule tip localization signal

Honnappa, S., Gouveia, S. M., Weisbrich, A., Damberger, F. F., Bhavesh, N. S., Jawhari, H., Grigoriev, I., van Rijssel, F. J. A., Buey, R. M., Lawera, A., et al. (2009) · Cell

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 611

Mammalian end binding proteins control persistent microtubule growth

Komarova, Y., De Groot, C. O., Grigoriev, I., Gouveia, S. M., Munteanu, E. L., Schober, J. M., Honnappa, S., Buey, R. M., Hoogenraad, C. C., Dogterom, M., et al. (2009) · Journal of Cell Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 387

A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins

Jiang, K., Toedt, G., Montenegro Gouveia, S., Davey, N. E., Hua, S., van der Vaart, B., Grigoriev, I., Larsen, J., Pedersen, L. B., Bezstarosti, K., et al. (2012) · Current Biology

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 209

Oligomerization and Multimerization Are Critical for Angiopoietin-1 to Bind and Phosphorylate Tie2

Kim, K.-T., Choi, H.-H., Steinmetz, M. O., Maco, B., Kammerer, R. A., Ahn, S. Y., Kim, H.-Z., Lee, G. M., & Koh, G. Y. (2005) · Journal of Biological Chemistry

Angiogenesis and VEGF in CancerCell Adhesion Molecules Research

Cited by 170

MAP7 family proteins regulate kinesin-1 recruitment and activation

Hooikaas, P. J., Martin, M., Mühlethaler, T., Kuijntjes, G.-J., Peeters, C. A. E., Katrukha, E. A., Ferrari, L., Stucchi, R., Verhagen, D. G. F., van Riel, W. E., et al. (2019) · Journal of Cell Biology

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 166

In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends

Montenegro Gouveia, S., Leslie, K., Kapitein, L. C., Buey, R. M., Grigoriev, I., Wagenbach, M., Smal, I., Meijering, E., Hoogenraad, C. C., Wordeman, L., et al. (2010) · Current Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 147

Molecular basis of coiled-coil formation

Steinmetz, M. O., Jelesarov, I., Matousek, W. M., Honnappa, S., Jahnke, W., Missimer, J. H., Frank, S., Alexandrescu, A. T., & Kammerer, R. A. (2007) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 136

Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity

Kevenaar, J. T., Bianchi, S., van Spronsen, M., Olieric, N., Lipka, J., Frias, C. P., Mikhaylova, M., Harterink, M., Keijzer, N., Wulf, P. S., et al. (2016) · Current Biology

Microtubule and mitosis dynamicsHereditary Neurological Disorders

Cited by 110

Structural insight into the stabilization of microtubules by taxanes

Prota, A. E., Lucena-Agell, D., Ma, Y., Estevez-Gallego, J., Li, S., Bargsten, K., Josa-Prado, F., Altmann, K.-H., Gaillard, N., Kamimura, S., et al. (2023) · eLife

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 78

GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses

Kashyap, A. S., Fernandez-Rodriguez, L., Zhao, Y., Monaco, G., Trefny, M. P., Yoshida, N., Martin, K., Sharma, A., Olieric, N., Shah, P., et al. (2019) · Cell Reports

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 76

Structural model for differential cap maturation at growing microtubule ends

Estévez-Gallego, J., Josa-Prado, F., Ku, S., Buey, R. M., Balaguer, F. A., Prota, A. E., Lucena-Agell, D., Kamma-Lorger, C., Yagi, T., Iwamoto, H., et al. (2020) · eLife

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 65

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

Atherton, J., Luo, Y., Xiang, S., Yang, C., Rai, A., Jiang, K., Stangier, M., Vemu, A., Cook, A. D., Wang, S., et al. (2019) · Nature Communications

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 48

Hydrolysis-deficient mosaic microtubules as faithful mimics of the GTP cap

Estévez-Gallego, J., Blum, T. B., Ruhnow, F., Gili, M., Speroni, S., García-Castellanos, R., Steinmetz, M. O., & Surrey, T. (2025) · Nature Communications

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 17

Structural basis of microtubule-mediated signal transduction

Choi, S. R., Blum, T. B., Giono, M., Roy, B., Vakonakis, I., Schmid, D., Oelgarth, N., Ranganathan, A., Gossert, A. D., Shivashankar, G. V., et al. (2026) · Cell

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamics

Cited by 14

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

Wranik, M., Kepa, M., Beale, E., James, D., Bertrand, Q., Weinert, T., Furrer, A., Glover, H., Gashi, D., Carrillo, M., et al. (2023) · Nature Communications

Enzyme Structure and FunctionAdvanced X-ray Imaging Techniques

Cited by 14

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

Wranik, M., Kepa, M. W., Beale, E. V., James, D., Bertrand, Q., Weinert, T., Furrer, A., Glover, H., Gashi, D., Carrillo, M., et al. (2023) · Nature Communications

Enzyme Structure and FunctionAdvanced X-ray Imaging Techniques

Cited by 14

Phase separation of a microtubule plus-end tracking protein into a fluid fractal network

Czub, M. P., Uliana, F., Grubić, T., Padeste, C., Rosowski, K. A., Lorenz, C., Dufresne, E. R., Menzel, A., Vakonakis, I., Gasser, U., et al. (2025) · Nature Communications

Microtubule and mitosis dynamicsRNA Research and Splicing

Cited by 12

Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling

Meiring, J. C. M., Mahapatra, V., Liu, R., Gravett, M. S. C., Morren, D., Saunders, H. A. J., Choi, S. R., Pelster José, A., Karhanova, A., Metallidou, I., et al. (2026) · Nature Cell Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 0