Ahmadian, Mohammad Reza

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 1,543

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

Tiede, I., Fritz, G., Strand, S., Poppe, D., Dvorsky, R., Strand, D., Lehr, H. A., Wirtz, S., Becker, C., Atreya, R., et al. (2003) · Journal of Clinical Investigation

Protein Kinase Regulation and GTPase SignalingCell death mechanisms and regulation

Cited by 828

GTPase-activating proteins: Helping hands to complement an active site

Scheffzek, K., Ahmadian, M. R., & Wittinghofer, A. (1998) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 410

The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling

Baran, P., Hansen, S., Waetzig, G. H., Akbarzadeh, M., Lamertz, L., Huber, H. J., Ahmadian, M. R., Moll, J. M., & Scheller, J. (2018) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 235

Rho-kinase: Regulation, (dys)function, and inhibition

Amin, E., Dubey, B. N., Zhang, S.-C., Gremer, L., Dvorsky, R., Moll, J. M., Taha, M. S., Nagel-Steger, L., Piekorz, R. P., Somlyo, A. V., et al. (2013) · bchm

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 176

Characterization of p190RhoGEF, A RhoA-specific Guanine Nucleotide Exchange Factor That Interacts with Microtubules

van Horck, F. P. G., Ahmadian, M. R., Haeusler, L. C., Moolenaar, W. H., & Kranenburg, O. (2001) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 174

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

Gremer, L., Merbitz-Zahradnik, T., Dvorsky, R., Cirstea, I. C., Kratz, C. P., Zenker, M., Wittinghofer, A., & Ahmadian, M. R. (2011) · Human Mutation

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 158

Individual Rate Constants for the Interaction of Ras Proteins with GTPase-Activating Proteins Determined by Fluorescence Spectroscopy

Ahmadian, M. R., Hoffmann, U., Goody, R. S., & Wittinghofer, A. (1997) · Biochemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 141

The interaction of Ras with GTPase‐activating proteins

Wittinghofer, A., Scheffzek, K., & Ahmadian, M. R. (1997) · FEBS Letters

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 135

IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy

Fazel Modares, N., Polz, R., Haghighi, F., Lamertz, L., Behnke, K., Zhuang, Y., Kordes, C., Häussinger, D., Sorg, U. R., Pfeffer, K., et al. (2019) · Hepatology

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 113

Deciphering the Molecular and Functional Basis of Dbl Family Proteins

Jaiswal, M., Dvorsky, R., & Ahmadian, M. R. (2013) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 108

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

Pena, V., Hothorn, M., Eberth, A., Kaschau, N., Parret, A., Gremer, L., Bonneau, F., Ahmadian, M. R., & Scheffzek, K. (2008) · The EMBO Reports

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 101

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)

Jaiswal, M., Gremer, L., Dvorsky, R., Haeusler, L. C., Cirstea, I. C., Uhlenbrock, K., & Ahmadian, M. R. (2011) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 68

Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition

Kapp, F. G., Bazgir, F., Mahammadzade, N., Mehrabipour, M., Vassella, E., Bernhard, S. M., Döring, Y., Holm, A., Karow, A., Seebauer, C., et al. (2024) · Angiogenesis

Vascular Malformations and HemangiomasVascular Malformations Diagnosis and Treatment

Cited by 20

The actin filament architecture: tightly regulated by the cells, manipulated by pathogens: International Titisee Conference on the actin cytoskeleton: from signalling to bacterial pathogenesis

Ahmadian, M. R., Wittinghofer, A., & Schmidt, G. (2002) · The EMBO Reports

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 10