Humbert, Patrick O.

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

Dow, L. E., Kauffman, J. S., Caddy, J., Peterson, A. S., Jane, S. M., Russell, S. M., & Humbert, P. O. (2007) · Oncogene

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 187

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R., et al. (2011) · Journal of Clinical Investigation

Prostate Cancer Treatment and ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 185

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

Dow, L. E., Elsum, I. A., King, C. L., Kinross, K. M., Richardson, H. E., & Humbert, P. O. (2008) · Oncogene

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 171

Intermittent hypoxia induces a metastatic phenotype in breast cancer

Chen, A., Sceneay, J., Gödde, N., Kinwel, T., Ham, S., Thompson, E. W., Humbert, P. O., & Möller, A. (2018) · Oncogene

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 133

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Stephens, R., Lim, K., Portela, M., Kvansakul, M., Humbert, P. O., & Richardson, H. E. (2018) · Journal of Molecular Biology

Hippo pathway signaling and YAP/TAZDevelopmental Biology and Gene Regulation

Cited by 132

Scribble Interacts with β-Catenin to Localize Synaptic Vesicles to Synapses

Sun, Y., Aiga, M., Yoshida, E., Humbert, P. O., & Bamji, S. X. (2009) · Molecular Biology of the Cell

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 93

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

Elsum, I. A., Martin, C., & Humbert, P. O. (2013) · Journal of Cell Science

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 87

Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium

Ivanov, A. I., Young, C., Beste, K. D., Capaldo, C. T., Humbert, P. O., Brennwald, P., Parkos, C. A., & Nusrat, A. (2010) · The American Journal of Pathology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 73

Vimentin Regulates Scribble Activity by Protecting It from Proteasomal Degradation

Phua, D. C. Y., Humbert, P. O., & Hunziker, W. (2009) · Molecular Biology of the Cell

Skin and Cellular Biology ResearchCellular Mechanics and Interactions

Cited by 68

Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland

Godde, N. J., Sheridan, J. M., Smith, L. K., Pearson, H. B., Britt, K. L., Galea, R. C., Yates, L. L., Visvader, J. E., & Humbert, P. O. (2014) · PLoS Genetics

Developmental Biology and Gene RegulationCancer Cells and Metastasis

Cited by 60

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

Elsum, I. A., Yates, L. L., Pearson, H. B., Phesse, T. J., Long, F., O'Donoghue, R., Ernst, M., Cullinane, C., & Humbert, P. O. (2014) · Oncogene

Protein Kinase Regulation and GTPase SignalingLung Cancer Treatments and Mutations

Cited by 60

Asymmetric cell division during T cell development controls downstream fate

Pham, K., Shimoni, R., Charnley, M., Ludford-Menting, M. J., Hawkins, E. D., Ramsbottom, K., Oliaro, J., Izon, D., Ting, S. B., Reynolds, J., et al. (2015) · Journal of Cell Biology

Developmental Biology and Gene RegulationT-cell and B-cell Immunology

Cited by 39

The polarity protein Scribble regulates myelination and remyelination in the central nervous system

Jarjour, A. A., Boyd, A., Dow, L. E., Holloway, R. K., Goebbels, S., Humbert, P. O., Williams, A., & ffrench-Constant, C. (2015) · PLOS Biology

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 39

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Pearson, H. B., McGlinn, E., Phesse, T. J., Schlüter, H., Srikumar, A., Gödde, N. J., Woelwer, C. B., Ryan, A., Phillips, W. A., Ernst, M., et al. (2015) · Molecular Cancer

Skin and Cellular Biology ResearchDevelopmental Biology and Gene Regulation

Cited by 39

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX

Lim, K. Y. B., Gödde, N. J., Humbert, P. O., & Kvansakul, M. (2017) · Journal of Biological Chemistry

Protein Structure and DynamicsProtein Kinase Regulation and GTPase Signaling

Cited by 34

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

Caria, S., Magtoto, C. M., Samiei, T., Portela, M., Lim, K. Y. B., How, J. Y., Stewart, B. Z., Humbert, P. O., Richardson, H. E., & Kvansakul, M. (2018) · Journal of Biological Chemistry

Developmental Biology and Gene RegulationHippo pathway signaling and YAP/TAZ

Cited by 28

Localization, Not Important in All Tumor-Suppressing Properties: A Lesson Learnt from Scribble

Elsum, I. A., & Humbert, P. O. (2013) · Cells Tissues Organs

Protein Kinase Regulation and GTPase SignalingHippo pathway signaling and YAP/TAZ

Cited by 27

Crystal structure of the human Scribble PDZ 1 domain bound to the PDZ ‐binding motif of APC

How, J. Y., Caria, S., Humbert, P. O., & Kvansakul, M. (2019) · FEBS Letters

Protein Structure and DynamicsProtein Kinase Regulation and GTPase Signaling

Cited by 19

Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Thüring, E.-M., Hartmann, C., Maddumage, J. C., Javorsky, A., Michels, B. E., Gerke, V., Banks, L., Humbert, P. O., Kvansakul, M., & Ebnet, K. (2023) · Communications Biology

Cell Adhesion Molecules ResearchHippo pathway signaling and YAP/TAZ

Cited by 7

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

Wölwer, C. B., Gödde, N., Pase, L. B., Elsum, I. A., Lim, K. Y. B., Sacirbegovic, F., Walkley, C. R., Ellis, S., Ohno, S., Matsuzaki, F., et al. (2017) · PLOS ONE

Developmental Biology and Gene RegulationHematopoietic Stem Cell Transplantation

Cited by 6