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Scribble Interacts with β-Catenin to Localize Synaptic Vesicles to Synapses

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Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

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Scribble‐mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

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Scribble is required for normal epithelial cell–cell contacts and lumen morphogenesis in the mammalian lung

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Human scribble, a novel tumor suppressor identified as a target of high‐risk HPV E6 for ubiquitin‐mediated degradation, interacts with adenomatous polyposis coli

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hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells

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Drosophila asymmetric division, polarity and cancer

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The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

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Sustained activation of the HER1–ERK1/2–RSK signaling pathway controls myoepithelial cell fate in human mammary tissuePreprint

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Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium

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The duration of ERK1/2 activity determines the activation of c-Fos and Fra-1 and the composition and quantitative transcriptional output of AP-1

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Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

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FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders

Chiappetta, G., Ferraro, A., Botti, G., Monaco, M., Pasquinelli, R., Vuttariello, E., Arnaldi, L. A. T., Bonito, M. D., D’Aiuto, G., Pierantoni, G. M., et al. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-17 · Cited by 56 · see citing works

Elevated expression of pp60c-src alters a selective morphogenetic property of epithelial cells in vitro without a mitogenic effect.

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Essential Role of c-Cbl in Amphiregulin-Induced Recycling and Signaling of the Endogenous Epidermal Growth Factor Receptor

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The Preneoplastic Phenotype in Murine Mammary Tumorigenesis

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Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study

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Human scribble accumulates in colorectal neoplasia in association with an altered distribution of β-catenin

Kamei, Y., Kito, K., Takeuchi, T., Imai, Y., Murase, R., Ueda, N., Kobayashi, N., & Abe, Y. (2007) · Human Pathology · doi:10.1016/j.humpath.2007.01.026 · Cited by 44 · see citing works

CD74-dependent deregulation of the tumor suppressor Scribble in human epithelial and breast cancer cells

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An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy

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Cell contacts in the mouse mammary gland

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Illuminating the Center: Mechanisms Regulating Lumen Formation and Maintenance in Mammary Morphogenesis

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hScrib, a Human Homolog of Drosophila Neoplastic Tumor Suppressor, Is Involved in the Progress of Endometrial Cancer

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Mammary Tumor Phenotypes in Wild-Type Aging Female FVB/N Mice with Pituitary Prolactinomas

Radaelli, E., Arnold, A., Παπανικολάου, Α., García-Fernández, R. A., Mattiello, S., Scanziani, E., & Cardiff, R. D. (2009) · Veterinary Pathology · doi:10.1354/vp.08-vp-0280-r-fl · Cited by 32 · see citing works

Role of ER in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis

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A βPIX-PAK2 Complex Confers Protection against Scrib-Dependent and Cadherin-Mediated Apoptosis

Frank, S. R., Bell, J. H., Frödin, M., & Hansen, S. H. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.011 · Cited by 28 · see citing works

Role of Fos‐related antigen 1 in the progression and prognosis of ductal breast carcinoma

Logullo, Â. F., Stiepcich, M. M., Osório, C. A. B. D. T., Nonogaki, S., Pasini, F. S., Rocha, R. M., Soares, F. A., & Brentani, M. M. (2011) · Histopathology · doi:10.1111/j.1365-2559.2011.03785.x · Cited by 26 · see citing works

Biological variables and prognosis of DCIS

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Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta

Lisovsky, M., Ogawa, F., Dresser, K., Woda, B. A., & Lauwers, G. Y. (2010) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-010-0990-9 · Cited by 15 · see citing works

Apical–basal polarity and the control of epithelial form and function

Buckley, C. E., & St Johnston, D. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00465-y · Cited by 295 · see citing works

Systematic morphological profiling of human gene and allele function via Cell Painting

Rohban, M. H., Singh, S., Wu, X., Hicks‐Berthet, J., Bray, M., Shrestha, Y., Varelas, X., Boehm, J. S., & Carpenter, A. E. (2017) · eLife · doi:10.7554/elife.24060 · Cited by 158 · see citing works

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Stephens, R., Lim, K., Portela, M., Kvansakul, M., Humbert, P. O., & Richardson, H. E. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.01.011 · Cited by 132 · see citing works

Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

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ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity

Chen, B., Zheng, B., DeRan, M., Jarugumilli, G. K., Fu, J., Brooks, Y. S., & Wu, X. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2119 · Cited by 119 · see citing works

Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

Glubb, D. M., Maranian, M. J., Michailidou, K., Pooley, K. A., Meyer, K. B., Kar, S., Carlebur, S., O’Reilly, M., Betts, J. A., Hillman, K. M., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.11.009 · Cited by 80 · see citing works

Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment

Daulat, A. M., & Borg, J. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.01.001 · Cited by 78 · see citing works

Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion

Saito, Y., Desai, R., & Muthuswamy, S. K. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.12.001 · Cited by 66 · see citing works

The Scribble family in cancer: twentieth anniversary

Santoni, M.-J., Kashyap, R., Camoin, L., & Borg, J.-P. (2020) · Oncogene · doi:10.1038/s41388-020-01478-7 · Cited by 62 · see citing works

Cell polarity changes in cancer initiation and progression

Péglion, F., & Etienne‐Manneville, S. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202308069 · Cited by 63 · see citing works

Progressive polarity loss and luminal collapse disrupt tissue organization in carcinomaPreprint

Halaoui, R., Rejon, C. A., Chatterjee, S. J., Szymborski, J., Meterissian, S. H., Muller, W. J., Ömeroğlu, A., & McCaffrey, L. M. (2017) · Genes & Development · doi:10.1101/gad.300566.117 · Cited by 61 · see citing works

The adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathway

Zhou, Y., Chu, X., Deng, F., Tong, L., Tong, G., Ye, Y., Liu, J., Tang, J. H., Tang, Y., Xia, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17835 · Cited by 59 · see citing works

Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex

Choi, J., Troyanovsky, R. B., Indra, I., Mitchell, B. J., & Troyanovsky, S. M. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201804201 · Cited by 53 · see citing works

FRA-1 as a Regulator of EMT and Metastasis in Breast Cancer

Casalino, L., Talotta, F., Matino, I., & Verde, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098307 · Cited by 42 · see citing works

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Pearson, H. B., McGlinn, E., Phesse, T. J., Schlüter, H., Srikumar, A., Gödde, N. J., Woelwer, C. B., Ryan, A., Phillips, W. A., Ernst, M., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0440-z · Cited by 39 · see citing works

The cell polarity protein Scrib functions as a tumor suppressor in liver cancer

Kapil, S., Sharma, B. K., Patil, M., Elattar, S., Yuan, J., Hou, X. S., Kolhe, R. B., & Ande, S. (2017) · Oncotarget · doi:10.18632/oncotarget.15713 · Cited by 40 · see citing works

Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium

Bazzoun, D., Adissu, H. A., Wang, L., Urazaev, A. K., Tenvooren, I., Fostok, S. F., Chittiboyina, S., Sturgis, J., Hodges, K. B., Chandramouly, G., et al. (2019) · Journal of Cell Science · doi:10.1242/jcs.223313 · Cited by 39 · see citing works

Modelling Cooperative Tumorigenesis in Drosophila

Richardson, H. E., & Portela, M. (2018) · BioMed Research International · doi:10.1155/2018/4258387 · Cited by 38 · see citing works

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX

Lim, K. Y. B., Gödde, N. J., Humbert, P. O., & Kvansakul, M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.799452 · Cited by 34 · see citing works

The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling

Almeida, L. L., Sebbagh, M., Bertucci, F., Finetti, P., Wicinski, J., Marchetto, S., Castellano, R., Josselin, E., Charafe‐Jauffret, E., Ginestier, C., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.09.008 · Cited by 27 · see citing works

Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis

Fahey-Lozano, N., Marca, J. E. L., Portela, M., & Richardson, H. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-23629-8_3 · Cited by 27 · see citing works

Blockade of Adenosine A2b Receptor Reduces Tumor Growth and Migration in Renal Cell Carcinoma

Ye, Y., Zhou, Y., Chu, X., Zheng, X., Fei, D., Lei, J., Qi, H., & Dai, Y. (2019) · Journal of Cancer · doi:10.7150/jca.31245 · Cited by 26 · see citing works

Cell Polarity Proteins in Breast Cancer Progression

Rejon, C. A., Al‐Masri, M., & McCaffrey, L. M. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25553 · Cited by 26 · see citing works

Dissecting the role of polarity regulators in cancer through the use of mouse models

Gödde, N., Pearson, H. B., Smith, L. K., & Humbert, P. O. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.08.036 · Cited by 25 · see citing works

Screening for Anti‐cancer Drugs inDrosophila

Richardson, H. E., Willoughby, L. F., & Humbert, P. O. (2015) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022535 · Cited by 24 · see citing works

Regulation of cellular and PCP signalling by the Scribble polarity module

Milgrom-Hoffman, M., & Humbert, P. O. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.11.021 · Cited by 22 · see citing works

Molecular mechanism of ER stress‐induced gene expression of tumor necrosis factor‐related apoptosis‐inducing ligand ( TRAIL ) in macrophages

Huang, Y., Wang, Y., Li, X., Chen, Z., Li, X., Wang, H., Ni, M.-M., & Li, J. (2015) · FEBS Journal · doi:10.1111/febs.13284 · Cited by 21 · see citing works

Structural analysis of phosphorylation‐associated interactions of human MCC with Scribble PDZ domains

Caria, S., Stewart, B. Z., Jin, R., Smith, B. J., Humbert, P. O., & Kvansakul, M. (2019) · FEBS Journal · doi:10.1111/febs.15002 · Cited by 21 · see citing works

PtdIns(3,4,5)P 3 -dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

Srijakotre, N., Liu, H.-J., Nobis, M., Man, J., Yip, H. Y. K., Papa, A., Abud, H. E., Anderson, K. I., Welch, H. C. E., Tiganis, T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006445117 · Cited by 20 · see citing works

Crystal structure of the human Scribble <scp>PDZ</scp> 1 domain bound to the <scp>PDZ</scp> ‐binding motif of <scp>APC</scp>

How, J. Y., Caria, S., Humbert, P. O., & Kvansakul, M. (2019) · FEBS Letters · doi:10.1002/1873-3468.13329 · Cited by 19 · see citing works

Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development

Avgustinova, A., Laudanna, C., Pascual-García, M., Rovira, Q., Djurec, M., Castellanos‐Martín, A., Urdiroz-Urricelqui, U., Marchese, D., Prats, N., Keymeulen, A. V., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.04.030 · Cited by 19 · see citing works

Scribble acts as an oncogene in Eμ-myc-driven lymphoma

Hawkins, E. D., Oliaro, J., Ramsbottom, K. M., Newbold, A., Humbert, P. O., Johnstone, R. W., & Russell, S. M. (2015) · Oncogene · doi:10.1038/onc.2015.167 · Cited by 19 · see citing works

Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models

McBryan, J., & Howlin, J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6475-8_3 · Cited by 18 · see citing works

Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis

Tamori, Y., & Deng, W. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.03.003 · Cited by 19 · see citing works

Genetic alterations of epithelial polarity genes are associated with loss of polarity in invasive breast cancer

Catterall, R., Lelarge, V., & McCaffrey, L. M. (2019) · International Journal of Cancer · doi:10.1002/ijc.32691 · Cited by 18 · see citing works

Afadin couples RAS GTPases to the polarity rheostat Scribble

Goudreault, M., Gagné, V., Jo, C. H., Singh, S., Killoran, R. C., Gingras, A., & Smith, M. J. (2022) · Nature Communications · doi:10.1038/s41467-022-32335-8 · Cited by 16 · see citing works

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

Humbert, P. O., Russell, S. M., Smith, L. K., & Richardson, H. E. (2015) · Springer eBooks · doi:10.1007/978-3-319-14463-4_4 · Cited by 17 · see citing works

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

Portela, M., Yang, L., Paul, S., Li, X., Veraksa, A. N., Parsons, L. M., & Richardson, H. E. (2018) · Science Signaling · doi:10.1126/scisignal.aar1976 · Cited by 16 · see citing works

High Expression of CD200 and CD200R1 Distinguishes Stem and Progenitor Cell Populations within Mammary Repopulating Units

Rauner, G., Kudinov, T., Gilad, S., Hornung, G., & Barash, I. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.05.013 · Cited by 14 · see citing works

A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation

Deen, N. N. A., Lanman, N. A., Chittiboyina, S., Lelièvre, S. A., Nasr, R., Nassar, F. J., zu Dohna, H., Haidar, M. A., & Talhouk, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-82057-y · Cited by 14 · see citing works

Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2

Ying, J., Yang, Y., Zhang, X., Dong, Z., & Chen, B. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400569121 · Cited by 11 · see citing works

Over-expression of miR-183-5p or miR-492 triggers invasion and proliferation and loss of polarity in non-neoplastic breast epithelium

Deen, N. N. A., Lanman, N. A., Chittiboyina, S., Fostok, S. F., Nasr, R., Lelièvre, S. A., & Talhouk, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-25663-8 · Cited by 11 · see citing works

Cancer invasion and metastasis: Insights from murine pubertal mammary gland morphogenesis

Githaka, J. M., Pirayeshfard, L., & Goping, I. S. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130375 · Cited by 11 · see citing works

Low SCRIB expression in fibroblasts promotes invasion of lung cancer cells

Wang, Y., Liu, H., Bian, Y., An, J., Duan, X., Wan, J., Yao, X., Du, C., Ni, C., Zhu, L., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117955 · Cited by 11 · see citing works

Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland

Baker, L., BeGora, M. D., Yeung, F. A., Feigin, M. E., Rosenberg, A. Z., Lowe, S. W., Kislinger, T., & Muthuswamy, S. K. (2016) · Journal of Cell Science · doi:10.1242/jcs.185413 · Cited by 10 · see citing works

Scrib module proteins: Control of epithelial architecture and planar spindle orientation

Nakajima, Y.-I. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.106001 · Cited by 6 · see citing works

Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo‐Rodríguez, C., Henríquez, J. A., Caligiuri, G., Teles, S. P., Park, Y., Evans, A., Barrera, L. N., Neeße, A., Grützmann, R., Aust, D. E., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-3419 · Cited by 5 · see citing works

Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms

Chann, A. S., Chen, Y., Kinwel, T., Humbert, P. O., & Russell, S. M. (2023) · Journal of Cell Science · doi:10.1242/jcs.260547 · Cited by 5 · see citing works

Polarity in breast development and cancer

Whitford, M. K., & McCaffrey, L. M. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.02.009 · Cited by 6 · see citing works

RNA atlas and competing endogenous RNA regulation in tissue-derived exosomes from luminal B and triple-negative breast cancer patients

Wang, J., Zhang, X., You, Z., Meng, Y., Fan, X., Qiao, G., & Pang, D. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1113115 · Cited by 5 · see citing works

Scribble promotes alveologenesis in the pregnant mammary gland for milk production

Aikawa, S., Yuan, J., Dewar, A., Sun, X., & Dey, S. K. (2020) · Reproduction · doi:10.1530/rep-20-0108 · Cited by 5 · see citing works

Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators inDrosophilaepithelial tumorigenesis

Türkel, N., Portela, M., Poon, C. L. C., Li, J., Brumby, A. M., & Richardson, H. E. (2015) · Biology Open · doi:10.1242/bio.012815 · Cited by 5 · see citing works

FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks

Al-Khayyat, W., Laframboise, T., Dougherty, J., Mendonca, M. S., Boreham, D. R., Tai, T. C., Thome, C., & Tharmalingam, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1659986 · Cited by 2 · see citing works

Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

Glubb, D. M., Maranian, M. J., Michailidou, K., Pooley, K. A., Meyer, K. B., Kar, S., Carlebur, S., Betts, J. A., Hillman, K. M., Kaufmann, S., et al. (2015)

The significance of human papillomavirus E6 PDZ binding motif on the transformation and immortalization of human neonatal keratinocytes

Dust, K. (2019) · Mspace (University of Manitoba)

A Scribble-E-cadherin complex controls daughter cell patterning by multiple mechanismsPreprint

Chann, A. S., Chen, Y., Kinwel, T., Humbert, P. O., & Russell, S. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.15.440081

Turner at the British Institution in 1806: a canvas united in a world divided

Shanes, E. (1999) · Apollo: The international magazine of arts

Stem Cell Division and Its Critical Role in Mammary Gland Development and Tumorigenesis: Current Progress and Remaining Challenges

Zeng, P., Shu, L.-Z., Zhou, Y., Huang, H., Wei, S., Liu, W.-J., & Deng, H. (2024) · Stem Cells and Development · doi:10.1089/scd.2024.0035

Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses

Almeida, L. L. (2017) · doi:10.70675/47b7c12fza236z4804z8a77ze790e0b04c36

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436 · see citing works

Abstract 3291: Defining the role of the cellular polarity regulator Scrib in epithelial tumorigenesis

Pearson, H. B., Gödde, N., Elsum, I. A., Ryan, A., Tennstedt, P., Simon, R., & Humbert, P. O. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-3291

Abstract 920: Mislocalization of the polarity protein Scribble promotes tumorigenesis in the mouse mammary gland

Feigin, M. E., Rosenberg, A. Z., Cardiff, R. D., & Muthuswamy, S. K. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-920

Morphogenesis is the key

Alderton, G. K. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2576

In-Vivo Characterization of Mammalian Polarity Genes as Novel Tumor Suppressors Involved in Breast Cancer Development and Progression in a Mouse Model

Rosenberg, A. Z. (2006) · doi:10.21236/ada462385