Hildebrand, Joanne M.

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,220

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 598

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

Jacobsen, A. V., Lowes, K. N., Tanzer, M. C., Lucet, I. S., Hildebrand, J. M., Petrie, E. J., van Delft, M. F., Liu, Z., Conos, S. A., Zhang, J.-G., et al. (2016) · Cell Death & Disease

Cell death mechanisms and regulationHeat shock proteins research

Cited by 160

Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

Hildebrand, J. M., Yi, Z., Buchta, C. M., Poovassery, J., Stunz, L. L., & Bishop, G. A. (2011) · Immunological Reviews

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 110

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.

Samson, A. L., Garnish, S. E., Hildebrand, J. M., & Murphy, J. M. (2021) · Science Signaling

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 82