McLellan, Jason S.

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchAdvanced Electron Microscopy Techniques and Applications

Cited by 8,897

SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness

Corbett, K. S., Edwards, D. K., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 1,615

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

Hsieh, C.-L., Goldsmith, J. A., Schaub, J. M., DiVenere, A. M., Kuo, H.-C., Javanmardi, K., Le, K. C., Wrapp, D., Lee, A. G., Liu, Y., et al. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchProtein Structure and Dynamics

Cited by 1,303

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

McLellan, J. S., Chen, M., Joyce, M. G., Sastry, M., Stewart-Jones, G. B. E., Yang, Y., Zhang, B., Chen, L., Srivatsan, S., Zheng, A., et al. (2013) · Science

Respiratory viral infections researchSARS-CoV-2 and COVID-19 Research

Cited by 1,126

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

Pallesen, J., Wang, N., Corbett, K. S., Wrapp, D., Kirchdoerfer, R. N., Turner, H. L., Cottrell, C. A., Becker, M. M., Wang, L., Shi, W., et al. (2017) · Proceedings of the National Academy of Sciences

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 1,073

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

McLellan, J. S., Chen, M., Leung, S., Graepel, K. W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., et al. (2013) · Science

Respiratory viral infections researchSARS-CoV-2 and COVID-19 Research

Cited by 883

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J.-P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K., et al. (2011) · Nature

HIV Research and TreatmentCarbohydrate Chemistry and Synthesis

Cited by 830

Pre-fusion structure of a human coronavirus spike protein

Kirchdoerfer, R. N., Cottrell, C. A., Wang, N., Pallesen, J., Yassine, H. M., Turner, H. L., Corbett, K. S., Graham, B. S., McLellan, J. S., & Ward, A. B. (2016) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 765

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

Wrapp, D., De Vlieger, D., Corbett, K. S., Torres, G. M., Wang, N., Van Breedam, W., Roose, K., van Schie, L., Hoffmann, M., Pöhlmann, S., et al. (2020) · Cell

SARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies Research

Cited by 610

Immunogenicity of a DNA vaccine candidate for COVID-19

Smith, T. R. F., Patel, A., Ramos, S., Elwood, D., Zhu, X., Yan, J., Gary, E. N., Walker, S. N., Schultheis, K., Purwar, M., et al. (2020) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 601

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

Kirchdoerfer, R. N., Wang, N., Pallesen, J., Wrapp, D., Turner, H. L., Cottrell, C. A., Corbett, K. S., Graham, B. S., McLellan, J. S., & Ward, A. B. (2018) · Scientific Reports

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 466

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

Krarup, A., Truan, D., Furmanova-Hollenstein, P., Bogaert, L., Bouchier, P., Bisschop, I. J. M., Widjojoatmodjo, M. N., Zahn, R., Schuitemaker, H., McLellan, J. S., et al. (2015) · Nature Communications

Respiratory viral infections researchSARS-CoV-2 and COVID-19 Research

Cited by 383

A proof of concept for structure-based vaccine design targeting RSV in humans

Crank, M. C., Ruckwardt, T. J., Chen, M., Morabito, K. M., Phung, E., Costner, P. J., Holman, L. A., Hickman, S. P., Berkowitz, N. M., Gordon, I. J., et al. (2019) · Science

Respiratory viral infections researchSARS-CoV-2 and COVID-19 Research

Cited by 333

Structure-Based Vaccine Antigen Design

Graham, B. S., Gilman, M. S. A., & McLellan, J. S. (2019) · Annual Review of Medicine

vaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Cited by 234

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Azoitei, M. L., Correia, B. E., Ban, Y.-E. A., Carrico, C., Kalyuzhniy, O., Chen, L., Schroeter, A., Huang, P.-S., McLellan, J. S., Kwong, P. D., et al. (2011) · Science

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 224

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

Walls, A. C., Miranda, M. C., Schäfer, A., Pham, M. N., Greaney, A., Arunachalam, P. S., Navarro, M.-J., Tortorici, M. A., Rogers, K., O’Connor, M. A., et al. (2021) · Cell

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 185

Prolonged evolution of the human B cell response to SARS-CoV-2 infection

Sakharkar, M., Rappazzo, C. G., Wieland-Alter, W. F., Hsieh, C.-L., Wrapp, D., Esterman, E. S., Kaku, C. I., Wec, A. Z., Geoghegan, J. C., McLellan, J. S., et al. (2021) · Science Immunology

SARS-CoV-2 and COVID-19 ResearchT-cell and B-cell Immunology

Cited by 174

Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape

Wang, L., Shi, W., Chappell, J. D., Joyce, M. G., Zhang, Y., Kanekiyo, M., Becker, M. M., van Doremalen, N., Fischer, R., Wang, N., et al. (2018) · Journal of Virology

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 169

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Ku, Z., Xie, X., Davidson, E., Ye, X., Su, H., Menachery, V. D., Li, Y., Yuan, Z., Zhang, X., Muruato, A. E., et al. (2021) · Nature Communications

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 160

Structural Definition of a Neutralization-sensitive Epitope on the MERS-CoV S1-NTD

Wang, N., Rosen, O., Wang, L., Turner, H. L., Stevens, L. J., Corbett, K. S., Bowman, C. A., Pallesen, J., Shi, W., Zhang, Y., et al. (2019) · Cell Reports

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 86

Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation

Sponholtz, M. R., Byrne, P. O., Lee, A. G., Ramamohan, A. R., Goldsmith, J. A., McCool, R. S., Zhou, L., Johnson, N. V., Hsieh, C.-L., Connors, M., et al. (2024) · Proceedings of the National Academy of Sciences

Cytomegalovirus and herpesvirus researchViral Infectious Diseases and Gene Expression in Insects

Cited by 37

Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin

Goldsmith, J. A., DiVenere, A. M., Maynard, J. A., & McLellan, J. S. (2022) · Cell Reports

Cell Adhesion Molecules ResearchBiochemical and Structural Characterization

Cited by 28

Distinct pathway for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses

Tse, A. L., Acreman, C. M., Ricardo-Lax, I., Berrigan, J., Lasso, G., Balogun, T., Kearns, F. L., Casalino, L., McClain, G. L., Chandran, A. M., et al. (2024) · PLoS Pathogens

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 10

Structural dynamics and allosteric communication of a SARS-like bat coronavirus spike glycoprotein

Balogun, T. A., Kearns, F. L., Calvó-Tusell, C., Tse, A. L., Acreman, C. M., Casalino, L., Lasso, G., Miller, E. H., Chandran, K., McLellan, J. S., et al. (2026) · Biophysical Journal

SARS-CoV-2 and COVID-19 ResearchProtein Structure and Dynamics

Cited by 0