A proof of concept for structure-based vaccine design targeting RSV in humans
Abstract
Building a better RSV vaccine: Respiratory syncytial virus (RSV) causes severe respiratory disease, especially in infants and the elderly. However, attempts to produce effective human vaccines have largely been unsuccessful. Structure-based design has been used to generate an RSV fusion glycoprotein stabilized in its prefusion conformation (DS-Cav1). This immunogen is highly effective in mice and macaques. Crank et al. now report the results of a phase I vaccine clinical trial using the stabilized prefusion DS-Cav1 molecule. Four weeks after immunization, these vaccines elicited substantially more high-quality antibody titers than those typically generated using earlier RSV immunogens. The findings provide a proof of concept for how structural biology can contribute to precision vaccine design. Science , this issue p. 505
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S-2P conformational stability translates into greater immunogenicity, based on preservation of neutralization-sensitive epitopes and improved protein expression.
“Moreover, S-2P conformational stability translates into greater immunogenicity,27-29 based on preservation of neutralization-sensitive epitopes at the apex of the prefusion molecule, as shown for respiratory syncytial virus F glycoprotein,30 and improved protein expression,27 which is particularly advantageous for gene-based antigen delivery.”
From An mRNA Vaccine against SARS-CoV-2 — Preliminary Report (2020) · cites this paper as [30]
Newfound structural insights into F protein conformation have revealed that vaccinating against the prefusion conformation elicits superior neutralizing antibody response.
“Although some candidates have failed clinical trials owing to insufficient neutralizing antibody titres174, newfound structural insights into F protein conformation have revealed that vaccinating against the prefusion conformation elicits superior neutralizing antibody response175–178.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [175]
Insight into the atomic-level structure of the RSV F protein allowed stable expression of the pre-F protein, leading to strongly enhanced immune responses and providing proof of concept for structure-based vaccine design.
“insight into the atomic-level structure of the protein has allowed for stable expression of the pre-F protein, leading to strongly enhanced immune responses and providing a proof of concept for structure-based vaccine design132,133”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [132]
Cites
KIM, H. W., CANCHOLA, J. G., BRANDT, C. D., PYLES, G., CHANOCK, R. M., JENSEN, K., & PARROTT, R. H. (1969) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a120955 · Cited by 1,981 · see citing works
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
McLellan, J. S., Chen, M., Joyce, M. G., Sastry, M., Stewart-Jones, G. B. E., Yang, Y., Zhang, B., Chen, L., Srivatsan, S., Zheng, A., et al. (2013) · Science · doi:10.1126/science.1243283 · Cited by 1,126 · see citing works
Self-citationKapikian, A. Z., MITCHELL, R. H., Chanock, R. M., Shvedoff, R. A., & STEWART, C. E. (1969) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a120954 · Cited by 1,035 · see citing works
Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
McLellan, J. S., Chen, M., Leung, S., Graepel, K. W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., et al. (2013) · Science · doi:10.1126/science.1234914 · Cited by 883 · see citing works
Self-citationGlezen, W. P., Paredes, A., Allison, J. E., Taber, L. H., & Frank, A. L. (1981) · The Journal of Pediatrics · doi:10.1016/s0022-3476(81)80829-3 · Cited by 684 · see citing works
CHIN, J., Magoffin, R. L., Shearer, L. A., SCHIEBLE, J. H., & Lennette, E. H. (1969) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a120957 · Cited by 630 · see citing works
RESPIRATORY VIRUS IMMUNIZATION
Fulginiti, V. A., Eller, J. J., Sieber, O. F., Joyner, J. W., Minamitani, M., & Meiklejohn, G. (1969) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a120956 · Cited by 609 · see citing works
Mazur, N. I., Higgins, D., Nunes, M. C., Melero, J. A., Langedijk, A. C., Horsley, N., Buchholz, U. J., Openshaw, P., McLellan, J. S., Englund, J. A., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30292-5 · Cited by 457 · see citing works
Self-citationMcLellan, J. S., Yang, Y., Graham, B. S., & Kwong, P. D. (2011) · Journal of Virology · doi:10.1128/jvi.00555-11 · Cited by 433 · see citing works
Self-citationPrefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera
Ngwuta, J. O., Chen, M., Modjarrad, K., Joyce, M. G., Kanekiyo, M., Kumar, A., Yassine, H. M., Moin, S. M., Killikelly, A. M., Chuang, G., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac4241 · Cited by 433 · see citing works
Self-citationMutants of Pertussis Toxin Suitable for Vaccine Development
Pizza, M., Covacci, A., Bartoloni, A., Perugini, M., Nencioni, L., Magistris, M. T. D., Villa, L., Nucci, D., Manetti, R., Bugnoli, M., et al. (1989) · Science · doi:10.1126/science.2683073 · Cited by 311 · see citing works
Murphy, B. R., Prince, G. A., Walsh, E. E., Kim, H. W., Parrott, R. H., Hemming, V. G., Rodriguez, W. J., & Chanock, R. M. (1986) · Journal of Clinical Microbiology · doi:10.1128/jcm.24.2.197-202.1986 · Cited by 304 · see citing works
Habibi, M. S., Jóźwik, A., Makris, S., Dunning, J. W., Paras, A., DeVincenzo, J. P., de Haan, C. A. M., Wrammert, J., Openshaw, P., & Chiu, C. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201412-2256oc · Cited by 289 · see citing works
Swanson, K. A., Settembre, E. C., Shaw, C. A., Dey, A. K., Rappuoli, R., Mandl, C. W., Dormitzer, P. R., & Carfi, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106536108 · Cited by 285 · see citing works
Magro, M., Mas, V., Chappell, K., Vázquez, M., Cano, O., Luque, D., Terrón, M. C., Melero, J. A., & Palomo, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115941109 · Cited by 271 · see citing works
Gilman, M. S. A., Castellanos, C. A., Chen, M., Ngwuta, J. O., Goodwin, E. C., Moin, S. M., Más, V., Melero, J. A., Wright, P. F., Graham, B. S., et al. (2016) · Science Immunology · doi:10.1126/sciimmunol.aaj1879 · Cited by 239 · see citing works
Self-citationMurphy, B. R., & Walsh, E. E. (1988) · Journal of Clinical Microbiology · doi:10.1128/jcm.26.8.1595-1597.1988 · Cited by 228 · see citing works
Relationship of Serum Antibody to Risk of Respiratory Syncytial Virus Infection in Elderly Adults
Falsey, A. R., & Walsh, E. E. (1998) · The Journal of Infectious Diseases · doi:10.1086/517376 · Cited by 173 · see citing works
Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV
Joyce, M. G., Zhang, B., Ou, L., Chen, M., Chuang, G., Druz, A., Kong, W., Lai, Y., Rundlet, E. J., Tsybovsky, Y., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3267 · Cited by 168 · see citing works
Self-citationGilman, M. S. A., Moin, S. M., Más, V., Chen, M., Patel, N., Kari, K., Zhu, Q., Kabeche, S. C., Kumar, A., Palomo, C., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005035 · Cited by 152 · see citing works
Self-citationGoodwin, E. C., Gilman, M., Wrapp, D., Chen, M., Ngwuta, J. O., Moin, S., Bai, P., Sivasubramanian, A., Connor, R., Wright, P., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.005 · Cited by 146 · see citing works
Self-citationAntigenic Structure of Human Respiratory Syncytial Virus Fusion Glycoprotein
López, J. A., Bustos, R., Örvell, C., Berois, M., Arbiza, J., García‐Barreno, B., & Melero, J. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.8.6922-6928.1998 · Cited by 123 · see citing works
Mousa, J. J., Kose, N., Matta, P., Gilchuk, P., & Crowe, J. E. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.271 · Cited by 111 · see citing works
August, A., Glenn, G. M., Kpamegan, E. P., Hickman, S. P., Jani, D., Lu, H., Thomas, D. N., Wen, J., Piedra, P. A., & Fries, L. F. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.05.045 · Cited by 98 · see citing works
Self-citationWen, X., Mousa, J. J., Bates, J. T., Lamb, R. A., Crowe, J. E., & Jardetzky, T. S. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.272 · Cited by 94 · see citing works
Rossey, I., Gilman, M. S. A., Kabeche, S. C., Sedeyn, K., Wrapp, D., Kanekiyo, M., Chen, M., Más, V., Spitaels, J., Melero, J. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14158 · Cited by 84 · see citing works
Self-citationFries, L. F., Shinde, V., Stoddard, J. J., Thomas, D. N., Kpamegan, E. P., Lu, H., Smith, G., Hickman, S. P., Piedra, P. A., & Glenn, G. M. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0090-7 · Cited by 75 · see citing works
Self-citationTian, D., Battles, M. B., Moin, S. M., Chen, M., Modjarrad, K., Kumar, A., Kanekiyo, M., Graepel, K. W., Taher, N. M., Hotard, A. L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01858-w · Cited by 71 · see citing works
Self-citationSimões, E. A. F., Tan, D. H. S., Ohlsson, A., Sales, V., & Wang, E. E. L. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00388-7 · Cited by 53 · see citing works
Mousa, J. J., Sauer, M. F., Sevy, A. M., Finn, J. A., Bates, J. T., Alvarado, G. S., King, H. G., Loerinc, L. B., Fong, R. H., Doranz, B. J., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609449113 · Cited by 53 · see citing works
Zhao, M., Zheng, Z., Chen, M., Modjarrad, K., Zhang, W., Zhan, L.-T., Cao, J., Sun, Y., McLellan, J. S., Graham, B. S., et al. (2017) · Journal of Virology · doi:10.1128/jvi.00176-17 · Cited by 35 · see citing works
Self-citationEpitope-Specific Serological Assays for RSV: Conformation Matters
Phung, E., Chang, L. A., Morabito, K. M., Kanekiyo, M., Chen, M., Nair, D., Kumar, A., Chen, G. L., Ledgerwood, J. E., Graham, B. S., et al. (2019) · Vaccines · doi:10.3390/vaccines7010023 · Cited by 34 · see citing works
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An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Jackson, L. A., Anderson, E. J., Rouphael, N. G., Roberts, P. C., Makhene, M., Coler, R. N., McCullough, M. P., Chappell, J. D., Denison, M. R., Stevens, L. J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2022483 · Cited by 3,237 · see citing works
Self-citationSARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness
Corbett, K. S., Edwards, D. K., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., et al. (2020) · Nature · doi:10.1038/s41586-020-2622-0 · Cited by 1,615 · see citing works
Self-citationA guide to vaccinology: from basic principles to new developments
Pollard, A. J., & Bijker, E. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00479-7 · Cited by 1,593 · see citing works
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555 · see citing works
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
Hsieh, C.-L., Goldsmith, J. A., Schaub, J. M., DiVenere, A. M., Kuo, H.-C., Javanmardi, K., Le, K. C., Wrapp, D., Lee, A. G., Liu, Y., et al. (2020) · Science · doi:10.1126/science.abd0826 · Cited by 1,303 · see citing works
Self-citationEvaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Corbett, K. S., Flynn, B., Foulds, K. E., Francica, J. R., Boyoglu-Barnum, S., Werner, A. P., Flach, B., O’Connell, S., Bock, K. W., Minai, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2024671 · Cited by 1,066 · see citing works
Self-citationSARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates
Kyriakidis, N. C., López‐Cortés, A., Vásconez-González, J., Barreto-Grimaldos, A., & Ortiz‐Prado, E. (2021) · npj Vaccines · doi:10.1038/s41541-021-00292-w · Cited by 682 · see citing works
Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults
Wilson, E. M. P., Goswami, J., Baqui, A. H., Doreski, P. A., Marc, G. P., Zaman, K., Monroy, J., Duncan, C. J. A., Ujiie, M., Rämet, M., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2307079 · Cited by 517 · see citing works
Self-citationThe role of vaccines in combatting antimicrobial resistance
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Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape
Mazur, N. I., Terstappen, J., Baral, R., Bardají, A., Beutels, P., Buchholz, U. J., Cohen, C., Crowe, J. E., Cutland, C., Eckert, L. O., et al. (2022) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(22)00291-2 · Cited by 428 · see citing works
Self-citationLeveraging artificial intelligence in the fight against infectious diseases
Wong, F. J., de la Fuente‐Núñez, C., & Collins, J. J. (2023) · Science · doi:10.1126/science.adh1114 · Cited by 320 · see citing works
Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery
Ho, W., Gao, M., Li, F., Li, Z., Zhang, X., & Xu, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001812 · Cited by 261 · see citing works
Accelerated COVID-19 vaccine development: milestones, lessons, and prospects
Bok, K., Sitar, S., Graham, B. S., & Mascola, J. R. (2021) · Immunity · doi:10.1016/j.immuni.2021.07.017 · Cited by 254 · see citing works
Self-citationDu, S., Cao, Y., Zhu, Q., Yü, P., Qi, F., Wang, G., Du, X., Bao, L., Deng, W., Zhu, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.035 · Cited by 238 · see citing works
mRNA vaccines for infectious diseases — advances, challenges and opportunities
Pardi, N., & Krammer, F. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01042-y · Cited by 246 · see citing works
De novo protein design enables the precise induction of RSV-neutralizing antibodies
Sesterhenn, F., Yang, C., Bonet, J., Cramer, J. T., Wen, X., Wang, Y., Chiang, C.-I., Abriata, L. A., Kucharska, I., Castoro, G., et al. (2020) · Science · doi:10.1126/science.aay5051 · Cited by 191 · see citing works
Espeseth, A. S., Cejas, P. J., Citron, M. P., Wang, D., DiStefano, D. J., Callahan, C., Donnell, G. O., Galli, J. D., Swoyer, R., Touch, S., et al. (2020) · npj Vaccines · doi:10.1038/s41541-020-0163-z · Cited by 190 · see citing works
Immunological Lessons from Respiratory Syncytial Virus Vaccine Development
Ruckwardt, T. J., Morabito, K. M., & Graham, B. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.007 · Cited by 185 · see citing works
Self-citationNeutrophilic inflammation in the respiratory mucosa predisposes to RSV infection
Habibi, M. S., Thwaites, R. S., Chang, M., Jóźwik, A., Paras, A., Kirsebom, F. C. M., Varese, A., Owen, A., Cuthbertson, L., James, P. L., et al. (2020) · Science · doi:10.1126/science.aba9301 · Cited by 174 · see citing works
SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity
Joyce, M. G., Chen, W., Sankhala, R. S., Hajduczki, A., Thomas, P. V., Choe, M., Martinez, E. J., Chang, W. C., Peterson, C. E., Morrison, E. B., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110143 · Cited by 179 · see citing works
Respiratory syncytial virus infection and novel interventions
Langedijk, A. C., & Bont, L. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00919-w · Cited by 178 · see citing works
Novel vaccine technologies for the 21st century
Mascola, J. R., & Fauci, A. S. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0243-3 · Cited by 171 · see citing works
Self-citationAliprantis, A. O., Shaw, C. A., Griffin, P., Farinola, N., Railkar, R. A., Cao, X., Liu, W., Sachs, J. R., Swenson, C. J., Lee, H., et al. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1829899 · Cited by 149 · see citing works
Vaccine Efficacy in Adults in a Respiratory Syncytial Virus Challenge Study
Schmöele-Thoma, B., Zareba, A., Jiang, Q. L., Maddur, M. S., Danaf, R., Mann, A., Eze, K., Fok‐Seang, J., Kabir, G., Catchpole, A. P., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2116154 · Cited by 138 · see citing works
Respiratory Syncytial Virus Vaccines: A Review of the Candidates and the Approved Vaccines
Topalidou, X., Kalergis, A. M., & Papazisis, G. (2023) · Pathogens · doi:10.3390/pathogens12101259 · Cited by 127 · see citing works
Swanson, K. A., Rainho-Tomko, J. N., Williams, Z. P., Lanza, L., Peredelchuk, M., Kishko, M., Pavot, V., Alamares-Sapuay, J. G., Adhikarla, H., Gupta, S., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba6466 · Cited by 115 · see citing works
Prevention and Treatment Strategies for Respiratory Syncytial Virus (RSV)
Gatt, D., Martin, I., AlFouzan, R., & Moraes, T. J. (2023) · Pathogens · doi:10.3390/pathogens12020154 · Cited by 120 · see citing works
Current Challenges in Vaccinology
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Williams, K. L., Bastian, A. R., Feldman, R., Omoruyi, E. V. E., Paepe, E. D., Hendriks, J., van Zeeburg, H., Godeaux, O., Langedijk, J. P. M., Schuitemaker, H., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa193 · Cited by 108 · see citing works
Che, Y., Gribenko, A. V., Song, X., Handke, L. D., Efferen, K. S., Tompkins, K. R., Kodali, S., Nuñez, L., Prasad, A. K., Phelan, L., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.ade6422 · Cited by 102 · see citing works
A Randomized Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine
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Vaccinology in the post−COVID-19 era
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Caserta, M. T., O’Leary, S. T., Muñoz, F. M., Ralston, S. L., O’Leary, S. T., Campbell, J. D., Ardura, M. I., Banerjee, R., Bryant, K. A., Caserta, M. T., et al. (2023) · PEDIATRICS · doi:10.1542/peds.2023-061803 · Cited by 95 · see citing works
Bottom-up de novo design of functional proteins with complex structural features
Yang, C., Sesterhenn, F., Bonet, J., van Aalen, E. A., Scheller, L., Abriata, L. A., Cramer, J. T., Wen, X., Rosset, S., Georgeon, S., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-020-00699-x · Cited by 84 · see citing works
Loomis, R. J., Stewart-Jones, G. B. E., Tsybovsky, Y., Caringal, R. T., Morabito, K. M., McLellan, J. S., Chamberlain, A. L., Nugent, S. T., Hutchinson, G. B., Kueltzo, L. A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00842 · Cited by 90 · see citing works
Self-citationSADOFF, J. C., Paepe, E. D., DeVincenzo, J. P., Gymnopoulou, E., Menten, J., Murray, B. J., Bastian, A. R., Vandebosch, A., Haazen, W., Noulin, N., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab003 · Cited by 89 · see citing works
Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins
Hsieh, C., Rush, S. A., Palomo, C., Chou, C., Pickens, W., Más, V., & McLellan, J. S. (2022) · Nature Communications · doi:10.1038/s41467-022-28931-3 · Cited by 88 · see citing works
Self-citationThe RH5-CyRPA-Ripr Complex as a Malaria Vaccine Target
Ragotte, R. J., Higgins, M. K., & Draper, S. J. (2020) · Trends in Parasitology · doi:10.1016/j.pt.2020.04.003 · Cited by 84 · see citing works
Ols, S., Lenart, K., Cerveira, R. A., Miranda, M. C., Brunette, N., Kochmann, J., Corcoran, M., Skotheim, R., Philomin, A., Cagigi, A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.08.011 · Cited by 80 · see citing works
Self-citationFalsey, A. R., Walsh, E. E., Scott, D. A., Gurtman, A., Zareba, A., Jansen, K. U., Gruber, W. C., Dormitzer, P. R., Swanson, K. A., Jiang, Q. L., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab611 · Cited by 82 · see citing works
Nuttens, C., Moyersoen, J., Curcio, D., Torres, Z. A., Baay, M. F. D., Vroling, H., Gessner, B. D., & Begier, E. M. (2024) · Infectious Diseases and Therapy · doi:10.1007/s40121-024-01012-2 · Cited by 82 · see citing works
Development of mRNA vaccines against respiratory syncytial virus (RSV)
Qiu, X., Xu, S., Lu, Y., Luo, Z., Yan, Y., Wang, C., & Ji, J. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.10.001 · Cited by 83 · see citing works
Pino, M., Abid, T., Ribeiro, S. P., Edara, V. V., Floyd, K. A., Smith, J. C., Latif, M. B., Sánchez, G. P., Dutta, D., Wang, S., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abh3634 · Cited by 77 · see citing works
Community-Wide Experimental Evaluation of the PROSS Stability-Design Method
Peleg, Y., Vincentelli, R., Collins, B. M., Chen, K., Livingstone, E. K., Weeratunga, S. K., Leneva, N., Guo, Q., Remans, K., Perez, K., et al. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166964 · Cited by 74 · see citing works
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Sharma, P., Joshi, R. V., Pritchard, R., Xu, K., & Eicher, M. A. (2023) · Molecules · doi:10.3390/molecules28186438 · Cited by 76 · see citing works
Loomis, R. J., DiPiazza, A. T., Falcone, S., Ruckwardt, T. J., Morabito, K. M., Abiona, O. M., Chang, L. A., Caringal, R. T., Presnyak, V., Narayanan, E., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.772864 · Cited by 70 · see citing works
Self-citationThe road to approved vaccines for respiratory syncytial virus
Ruckwardt, T. J. (2023) · npj Vaccines · doi:10.1038/s41541-023-00734-7 · Cited by 75 · see citing works
Self-citationDurham, N. D., Agrawal, A., Waltari, E., Croote, D., Zanini, F., Davidson, E., Fouch, M. E., Smith, O., Carabajal, E., Pak, J. E., et al. (2019) · eLife · doi:10.7554/elife.52384 · Cited by 69 · see citing works
Mukhamedova, M., Wrapp, D., Shen, C., Gilman, M. S. A., Ruckwardt, T. J., Schramm, C. A., Ault, L., Chang, L. A., Derrien-Colemyn, A., Lucas, S. A. M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.03.004 · Cited by 68 · see citing works
Self-citationRuckwardt, T. J., Morabito, K. M., Phung, E., Crank, M. C., Costner, P. J. M., Holman, L. A., Chang, L. A., Hickman, S. P., Berkowitz, N. M., Gordon, I. J., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00098-9 · Cited by 68 · see citing works
Self-citationBebia, Z., Reyes, O., Jeanfreau, R. J., Kantele, A., León, R. G. D., Sánchez, M. G., Banooni, P., Gardener, G. J., Rasero, J. L. B., Pardilla, M. B. E., et al. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad024 · Cited by 68 · see citing works
The impact of human vaccines on bacterial antimicrobial resistance. A review
Jansen, K., Gruber, W., Simon, R., Wassil, J., & Anderson, A. S. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01274-z · Cited by 64 · see citing works
SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates
Li, T., Zheng, Q., Yu, H. J., Wu, D., Xue, W., Xiong, H., Huang, X., Nie, M., Yue, M., Rong, R., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1821583 · Cited by 67 · see citing works
Role of Respiratory Syncytial Virus in Pediatric Pneumonia
Bianchini, S., Silvestri, E., Argentiero, A., Fainardi, V., Pisi, G., & Esposito, S. (2020) · Microorganisms · doi:10.3390/microorganisms8122048 · Cited by 66 · see citing works
Cassetti, M. C., Pierson, T. C., Patterson, L. J., Bok, K., DeRocco, A. J., Deschamps, A. M., Graham, B. S., Erbelding, E. J., & Fauci, A. S. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac296 · Cited by 66 · see citing works
Self-citationSingh, K., Burkhardt, M., Nakuchima, S., Herrera, R., Muratova, O. V., Gittis, A. G., Kelnhofer, E., Reiter, K., Smelkinson, M. G., Veltri, D., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01123-9 · Cited by 65 · see citing works
Lu, M., Dravid, P., Zhang, Y., Trivedi, S., Li, A., Harder, O. E., Mahesh, K. C., Chaiwatpongsakorn, S., Zani, A., Kenney, A. D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2026153118 · Cited by 65 · see citing works
Host Responses to Respiratory Syncytial Virus Infection
Agac, A., Kolbe, S. M., Ludlow, M., Osterhaus, A. D. M. E., Meineke, R., & Rimmelzwaan, G. F. (2023) · Viruses · doi:10.3390/v15101999 · Cited by 69 · see citing works
Innovations in structure-based antigen design and immune monitoring for next generation vaccines
Ward, A. B., & Wilson, I. A. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.03.013 · Cited by 62 · see citing works
Current State and Challenges in Developing Respiratory Syncytial Virus Vaccines
Biagi, C., Dondi, A., Scarpini, S., Rocca, A., Vandini, S., Poletti, G., & Lanari, M. (2020) · Vaccines · doi:10.3390/vaccines8040672 · Cited by 61 · see citing works
Shaw, C. A., Essink, B. J., Harper, C., Mithani, R., Kapoor, A., Dhar, R., Wilson, L. A., Guo, R., Panozzo, C. A., Wilson, E. M. P., et al. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae081 · Cited by 61 · see citing works
Self-citationZhou, W., Jiang, L., Liao, S., Wu, F., Yang, G., Hou, L., Liu, L., Pan, X., Jia, W. W.-G., & Zhang, Y. (2023) · Viruses · doi:10.3390/v15081760 · Cited by 62 · see citing works
Current progress in the development of prophylactic and therapeutic vaccines
Li, T., Qian, C., Gu, Y., Zhang, J., Li, S., & Xia, N. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2230-4 · Cited by 57 · see citing works
Promoting versatile vaccine development for emerging pandemics
Monrad, J. T., Sandbrink, J. B., & Cherian, N. G. (2021) · npj Vaccines · doi:10.1038/s41541-021-00290-y · Cited by 58 · see citing works
Clinical development of therapeutic mRNA applications
Żak, M. M., & Zangi, L. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.034 · Cited by 62 · see citing works
The Journey to RSV Vaccines — Heralding an Era of Structure-Based Design
Graham, B. S. (2023) · New England Journal of Medicine · doi:10.1056/nejmp2216358 · Cited by 54 · see citing works
Self-citationLin, G.-L., Drysdale, S. B., Snape, M. D., O’Connor, D., Brown, A., MacIntyre-Cockett, G., Mellado-Gomez, E., de Cesare, M., Bonsall, D., Ansari, M. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25265-4 · Cited by 48 · see citing works
Chang, L. A., Phung, E., Crank, M. C., Morabito, K. M., Villafana, T. L., Dubovsky, F., Falloon, J., Esser, M. T., Lin, B. C., Chen, G. L., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.ade0424 · Cited by 45 · see citing works
Self-citationHumoral Immunogenicity of mRNA-1345 RSV Vaccine in Older Adults
Goswami, J., Baqui, A. H., Doreski, P. A., Marc, G. P., Jimenez, G., Ahmed, S., Zaman, K., Duncan, C. J. A., Ujiie, M., Rämet, M., et al. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae316 · Cited by 47 · see citing works
Structural basis for respiratory syncytial virus and human metapneumovirus neutralization
Miller, R. J., & Mousa, J. J. (2023) · Current Opinion in Virology · doi:10.1016/j.coviro.2023.101337 · Cited by 46 · see citing works
Can We AlphaFold Our Way Out of the Next Pandemic?
Higgins, M. K. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167093 · Cited by 46 · see citing works
Innate and adaptive immune responses in respiratory virus infection: implications for the clinic
Stambas, J., Lu, C., & Tripp, R. A. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1807945 · Cited by 46 · see citing works
Antibody-guided structure-based vaccines
Kwong, P. D., DeKosky, B. J., & Ulmer, J. B. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101428 · Cited by 43 · see citing works
Self-citationProfiles of current COVID-19 vaccines
Heinz, F. X., & Stiasny, K. (2021) · Wiener klinische Wochenschrift · doi:10.1007/s00508-021-01835-w · Cited by 45 · see citing works
Controlled Human Infection Models To Accelerate Vaccine Development
Choy, R. K. M., Bourgeois, A. L., Ockenhouse, C. F., Walker, R. I., Sheets, R., & Flores, J. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-21 · Cited by 44 · see citing works
Priorities for developing respiratory syncytial virus vaccines in different target populations
Drysdale, S. B., Barr, R. S., Rollier, C. S., Green, C., Pollard, A. J., & Sande, C. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax2466 · Cited by 43 · see citing works
Antibody recognition of the Pneumovirus fusion protein trimer interface
Huang, J., Diaz, D., & Mousa, J. J. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008942 · Cited by 43 · see citing works
50 Years of structural immunology
Wilson, I. A., & Stanfield, R. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100745 · Cited by 43 · see citing works
Using cross-species vaccination approaches to counter emerging infectious diseases
Warimwe, G. M., Francis, M. J., Bowden, T. A., Thumbi, S. M., & Charleston, B. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00567-2 · Cited by 42 · see citing works
Schwarz, T. F., Johnson, C., Grigat, C., Apter, D. L., Csonka, P., Lindblad, N., Nguyên, T. L.-A., Gao, F. F., Qian, H., Tullio, A. N., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab317 · Cited by 42 · see citing works
Houser, K. V., Gaudinski, M. R., Happe, M., Narpala, S., Verardi, R., Sarfo, E. K., Corrigan, A. R., Wu, R., Rothwell, R. S., Novik, L., et al. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101477 · Cited by 42 · see citing works
Self-citationAscough, S., Dayananda, P., Kalyan, M., Ung, S. K. A., Gardener, Z., Bergstrom, E., Paterson, S., Kar, S., Avadhan, V., Thwaites, R. S., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00103-9 · Cited by 42 · see citing works
Self-citationStuart, A. S. V., Virta, M., Williams, K. L., Seppä, I., Hartvickson, R., Greenland, M., Omoruyi, E. V. E., Bastian, A. R., Haazen, W., Salisch, N. C., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac407 · Cited by 41 · see citing works
Bakkers, M. J. G., Ritschel, T., Tiemessen, M. M., Dijkman, J., Zuffianò, A. A., Yu, X., van Overveld, D., Le, L., Voorzaat, R., van Haaren, M. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50659-5 · Cited by 41 · see citing works
A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant
Zhao, B., Yang, J., He, B., Li, X., Yan, H., Liu, S., Yang, Y., Zhou, D., Liu, B., Fan, X., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109401 · Cited by 39 · see citing works
Bliss, C. M., Freyn, A. W., Caniels, T. G., Leyva-Grado, V. H., Nachbagauer, R., Sun, W., Tan, G. S., Gillespie, V., McMahon, M., Krammer, F., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.011 · Cited by 40 · see citing works
Leveraging deep learning to improve vaccine design
Hederman, A. P., & Ackerman, M. E. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.03.002 · Cited by 40 · see citing works
Zhong, L., Zhang, W., Krummenacher, C., Chen, Y., Zheng, Q., Zhao, Q., Zeng, M., Xia, N., Zeng, Y., Xu, M., et al. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.03.001 · Cited by 38 · see citing works
van der Fits, L., Bolder, R., der Meer, M. H.-V., Drijver, J., van Polanen, Y., Serroyen, J., Langedijk, J. P. M., Schuitemaker, H., Saeland, E., & Zahn, R. C. (2020) · npj Vaccines · doi:10.1038/s41541-020-0200-y · Cited by 36 · see citing works
Wen, X., Suryadevara, N., Kose, N., Liu, J., Zhan, X., Handal, L. S., Williamson, L. E., Trivette, A., Carnahan, R. H., Jardetzky, T. S., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.07.002 · Cited by 36 · see citing works
Fatal enhanced respiratory syncytial virus disease in toddlers
Polack, F. P., Álvarez-Paggi, D., Libster, R., Caballero, M. T., Blair, R. V., Hijano, D. R., Niveyro, P. X. D. L. I., Menéndez, D., Gladwell, W., Avendano, L. M., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7843 · Cited by 37 · see citing works
Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases
Rouf, N. Z., Biswas, S., Tarannum, N., Oishee, L. M., & Muna, M. M. (2022) · RNA Biology · doi:10.1080/15476286.2022.2055923 · Cited by 36 · see citing works
Contribution of Dendritic Cells in Protective Immunity against Respiratory Syncytial Virus Infection
Jung, H. E., Kim, T. H., & Lee, H. K. (2020) · Viruses · doi:10.3390/v12010102 · Cited by 35 · see citing works
Langowski, M. D., Khan, F. A., Bitzer, A. A., Genito, C. J., Schrader, A. J., Martin, M. L., Soto, K., Zou, X., Hadiwidjojo, S., Beck, Z., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911792117 · Cited by 35 · see citing works
Joyce, M. G., Bao, A., Chen, M., Georgiev, I. S., Ou, L., Bylund, T., Druz, A., Kong, W., Peng, D., Rundlet, E. J., et al. (2019) · Pathogens and Immunity · doi:10.20411/pai.v4i2.338 · Cited by 35 · see citing works
Self-citationShaw, C. A., Mithani, R., Kapoor, A., Dhar, R., Wilson, L., Asmar, L. E., Ghamloush, S. S., Schaefers, K., August, A., Stoszek, S., et al. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae035 · Cited by 35 · see citing works
Self-citationLandscape of respiratory syncytial virus
Duan, Y., Liu, Z., Zang, N., Cong, B., Shi, Y., Xu, L., Jiang, M., Wang, P., Zou, J., Zhang, H., et al. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003354 · Cited by 36 · see citing works
Andreano, E., Paciello, I., Bardelli, M., Tavarini, S., Sammicheli, C., Frigimelica, E., Guidotti, S., Torricelli, G., Biancucci, M., D’Oro, U., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114035 · Cited by 34 · see citing works
COVID‐19 vaccines: Knowing the unknown
Lv, H., Wu, N. C., & Mok, C. K. P. (2020) · European Journal of Immunology · doi:10.1002/eji.202048663 · Cited by 32 · see citing works
Vaccines against human respiratory syncytial virus in clinical trials, where are we now?
Rossey, I., & Saelens, X. (2019) · Expert Review of Vaccines · doi:10.1080/14760584.2019.1675520 · Cited by 32 · see citing works
- Authors
- Crank, M. C., Ruckwardt, T. J., Chen, M., Morabito, K. M., Phung, E., Costner, P. J., Holman, L. A., Hickman, S. P., Berkowitz, N. M., Gordon, I. J., Yamshchikov, G. V., Gaudinski, M. R., Kumar, A., Chang, L. A., Moin, S. M., Hill, J. P., DiPiazza, A. T., Schwartz, R. M., Kueltzo, L., Cooper, J. W., Chen, P., Stein, J. A., Carlton, K., Gall, J. G., Nason, M. C., Kwong, P. D., Chen, G. L., Mascola, J. R., McLellan, J. S., Ledgerwood, J. E., Graham, B. S., the VRC 317 Study Team, Novik, L., Saunders, J., Mendoza, F., Whalen, W., Eshun, A., Cunningham, J., Wang, X., Hicks, R., Sitar, S., Hendel, C. S., Ola, A., Requilman, L., Tran, C., Nguyen, T., Williams, P., Boyd, C., Trofmenko, O., Carter, C., & Widge, A.
- Affiliations
- National Institutes of Health (US)
- The University of Texas at Austin (US)
- Corresponding author
- Crank, Michelle C.
- Ruckwardt, Tracy J.
- Chen, Man
- Graham, Barney S.
- ORCID
- Crank, Michelle C.
- Ruckwardt, Tracy J.
- Chen, Man
- Morabito, Kaitlyn M.
- Phung, Emily
- Holman, LaSonji A.
- Gordon, Ingelise J.
- Gaudinski, Martin R.
- Chang, Lauren A.
- Moin, Syed M.
- DiPiazza, Anthony T.
- Schwartz, Richard M.
- Kueltzo, Lisa
- Chen, Peifeng
- Carlton, Kevin
- Gall, Jason G.
- Nason, Martha C.
- Kwong, Peter D.
- Chen, Grace L.
- Mascola, John R.
- McLellan, Jason S.
- Ledgerwood, Julie E.
- Graham, Barney S.
- Novik, Laura
- Saunders, Jamie
- Whalen, William
- Cunningham, Jennifer
- Wang, Xiaolin
- Widge, Alicia
- Venue
- Science
- Published
- 2019-08-02
- Volume
- 365
- Issue
- 6452
- Pages
- 505-509
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2964965456
- Cited by
- 333
- References
- 32
- Citations by year
- 2026: 30 · 2025: 54 · 2024: 48 · 2023: 47 · 2022: 40 · 2021: 55 · 2020: 47 · 2019: 12
- FWCI
- 29.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (Intramural Funding)
- Bill and Melinda Gates Foundation (OPP1147555)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- respiratory syncytial virus, RSV F glycoprotein, structure-based vaccine design, subunit vaccine, neutralizing antibodies, protein engineering
- MeSH terms
- Immunogenicity, Vaccine, Adolescent, Adult, Antibodies, Viral, Humans, Middle Aged, Viral Fusion Proteins, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, Epitope Mapping, Respiratory Syncytial Virus Vaccines, Young Adult, Antibodies, Neutralizing
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