Youm, Yun-Hee

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,655

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,172

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., et al. (2013) · Cell Metabolism

Inflammasome and immune disordersGenetics, Aging, and Longevity in Model Organisms

Cited by 674

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y.-H., Brown, C. W., Elsworth, J., et al. (2017) · Nature

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 456

Caloric restriction in humans reveals immunometabolic regulators of health span

Spadaro, O., Youm, Y., Shchukina, I., Ryu, S., Sidorov, S., Ravussin, A., Nguyen, K., Aladyeva, E., Predeus, A. N., Smith, S. R., et al. (2022) · Science

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 317

Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution

Yang, H., Youm, Y.-H., & Dixit, V. D. (2009) · The Journal of Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 196

The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence

Youm, Y.-H., Kanneganti, T.-D., Vandanmagsar, B., Zhu, X., Ravussin, A., Adijiang, A., Owen, J. S., Thomas, M. J., Francis, J., Parks, J. S., et al. (2012) · Cell Reports

Inflammasome and immune disordersT-cell and B-cell Immunology

Cited by 172

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Youm, Y.-H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A., & Dixit, V. D. (2016) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyFibroblast Growth Factor Research

Cited by 129

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

Lee, A. H., Orliaguet, L., Youm, Y.-H., Maeda, R., Dlugos, T., Lei, Y., Coman, D., Shchukina, I., Andhey, P. S., Smith, S. R., et al. (2025) · Nature Metabolism

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 45

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

Mishra, M., Kim, H.-H., Youm, Y.-H., Gonzalez-Hurtado, E., Zaitsev, K., Dlugos, T., Shchukina, I., Gliniak, C., Ravussin, E., Mohanty, S., et al. (2026) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsComplement system in diseases

Cited by 10