Sears, Cynthia L.

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 1,812

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., Quesada, P., Sahin, I., Chandra, V., San Lucas, A., et al. (2019) · Cell

Gut microbiota and healthPancreatic and Hepatic Oncology Research

Cited by 1,577

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

Llosa, N. J., Cruise, M., Tam, A., Wicks, E. C., Hechenbleikner, E. M., Taube, J. M., Blosser, R. L., Fan, H., Wang, H., Luber, B. S., et al. (2015) · Cancer Discovery

Cancer Immunotherapy and BiomarkersGenetic factors in colorectal cancer

Cited by 1,487

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., et al. (2018) · Science

Gut microbiota and healthBacterial biofilms and quorum sensing

Cited by 1,105

Microbiota organization is a distinct feature of proximal colorectal cancers

Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences

Gut microbiota and healthBacterial biofilms and quorum sensing

Cited by 700

The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients

Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., et al. (2015) · Clinical Infectious Diseases

Clostridium difficile and Clostridium perfringens researchGut microbiota and health

Cited by 625

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis -induced colon tumorigenesis

Goodwin, A. C., Shields, C. E. D., Wu, S., Huso, D. L., Wu, X., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L., et al. (2011) · Proceedings of the National Academy of Sciences

Polyamine Metabolism and ApplicationsBacterial Cancer Therapy

Cited by 612

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

McAllister, F., Bailey, J. M., Alsina, J., Nirschl, C. J., Sharma, R., Fan, H., Rattigan, Y., Roeser, J. C., Lankapalli, R. H., Zhang, H., et al. (2014) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 405

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia

Drewes, J. L., White, J. R., Dejea, C. M., Fathi, P., Iyadorai, T., Vadivelu, J., Roslani, A. C., Wick, E. C., Mongodin, E. F., Loke, M. F., et al. (2017) · npj Biofilms and Microbiomes

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 335

Perspective: Alpha-Bugs, Their Microbial Partners, and the Link to Colon Cancer

Sears, C. L., & Pardoll, D. M. (2011) · The Journal of Infectious Diseases

Gut microbiota and healthBacterial Cancer Therapy

Cited by 259

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic

Tomkovich, S., Dejea, C. M., Winglee, K., Drewes, J. L., Chung, L., Housseau, F., Pope, J. L., Gauthier, J., Sun, X., Mühlbauer, M., et al. (2019) · Journal of Clinical Investigation

Gut microbiota and healthBacterial biofilms and quorum sensing

Cited by 209

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N. J., Smith, K. N., Tam, A., Ganguly, S., Wanyiri, J. W., et al. (2016) · Cancer Research

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 143

Intestinal bacteria maintain adult enteric nervous system and nitrergic neurons via Toll-like receptor 2-induced neurogenesis in mice

Yarandi, S. S., Kulkarni, S., Saha, M., Sylvia, K. E., Sears, C. L., & Pasricha, P. J. (2020) · Gastroenterology

Gastrointestinal motility and disordersGut microbiota and health

Cited by 138

Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy

Drewes, J. L., Housseau, F., & Sears, C. L. (2016) · British Journal of Cancer

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 121

Participation of African Americans in e-Health and m-Health Studies: A Systematic Review

James, D. C., Harville, C., Sears, C., Efunbumi, O., & Bondoc, I. (2017) · Telemedicine and e-Health

Mobile Health and mHealth ApplicationsEthics in Clinical Research

Cited by 78

A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors

Shaikh, F. Y., White, J. R., Gills, J. J., Hakozaki, T., Richard, C., Routy, B., Okuma, Y., Usyk, M., Pandey, A., Weber, J. S., et al. (2021) · Clinical Cancer Research

Cancer Immunotherapy and BiomarkersGut microbiota and health

Cited by 44

The intestinal microbiome influences checkpoint blockade

Sears, C. L., & Pardoll, D. M. (2018) · Nature Medicine

Cancer Immunotherapy and BiomarkersGut microbiota and health

Cited by 43

Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors

Shaikh, F. Y., Gills, J. J., Mohammad, F., White, J. R., Stevens, C. M., Ding, H., Fu, J., Tam, A., Blosser, R. L., Domingue, J. C., et al. (2022) · Cancer Immunology, Immunotherapy

Cancer Immunotherapy and BiomarkersGut microbiota and health

Cited by 30