Microbiota organization is a distinct feature of proximal colorectal cancers
Open accessAbstract
Significance: We demonstrate, to our knowledge for the first time, that bacterial biofilms are associated with colorectal cancers, one of the leading malignancies in the United States and abroad. Colon biofilms, dense communities of bacteria encased in a likely complex matrix that contact the colon epithelial cells, are nearly universal on right colon tumors. Most remarkably, biofilm presence correlates with bacterial tissue invasion and changes in tissue biology with enhanced cellular proliferation, a basic feature of oncogenic transformation occurring even in colons without evidence of cancer. Microbiome profiling revealed that biofilm communities on paired normal mucosa cluster with tumor microbiomes but lack distinct taxa differences. This work introduces a previously unidentified concept whereby microbial community structural organization exhibits the potential to contribute to disease progression.
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Enrichment of bacterial species from oral cavity is characteristic of CRC GOMS, along with enrichment in invasive polymicrobial bacterial biofilms in patients with right-sided tumours.
“The enrichment of bacterial species from the oral cavity is characteristic of the CRC GOMS50,76–79, along with an enrichment in invasive polymicrobial bacterial biofilms in patients with right-sided tumours76,80,81.”
From Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy (2023) · cites this paper as [81]
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- Authors
- Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., Stein, E., Vadivelu, J., Roslani, A. C., Malik, A. A., Wanyiri, J. W., Goh, K. L., Thevambiga, I., Fu, K., Wan, F., Llosa, N., Housseau, F., Romans, K., Wu, X., McAllister, F. M., Wu, S., Vogelstein, B., Kinzler, K. W., Pardoll, D. M., & Sears, C. L.
- Affiliations
- Departments of aMicrobiology and Immunology and
- Departments of bSurgery,
- Independent Consultant, Baltimore, MD 21231;
- Marine Biological Laboratory, Woods Hole, MA 02543;
- Marine Biological Laboratory (US)
- J. Craig Venter Institute (US)
- Medicine, and
- University of Malaya (MY)
- Departments of hSurgery and
- Department of Microbiology, University of Malaya, Kuala Lumpur 50603, Malaysia;
- Johns Hopkins University (US)
- Howard Hughes Medical Institute (US)
- ORCID
- Dejea, Christine M.
- Wick, Elizabeth C.
- Hechenbleikner, Elizabeth M.
- White, James R.
- Rossetti, Blair J.
- Borisy, Gary G.
- Lazarev, Mark
- Stein, Ellen
- Vadivelu, Jamuna
- Roslani, April C.
- Malik, Ausuma A.
- Goh, Khean L.
- Fu, Kai
- Wan, Fengyi
- Llosa, Nicolas
- Housseau, Franck
- Wu, XinQun
- McAllister, Florencia M.
- Wu, Shaoguang
- Vogelstein, Bert
- Kinzler, Kenneth W.
- Pardoll, Drew M.
- Sears, Cynthia L.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-12-08
- Volume
- 111
- Issue
- 51
- Pages
- 18321-18326
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4280621
- OpenAlex
- W1993952805
- Cited by
- 700
- References
- 27
- Citations by year
- 2026: 42 · 2025: 39 · 2024: 53 · 2023: 94 · 2022: 62 · 2021: 86 · 2020: 67 · 2019: 66 · 2018: 71 · 2017: 53 · 2016: 44 · 2015: 22
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Alexander and Margaret Stewart Trust (300-2344)
- Johns Hopkins University (P30CA006973)
- Institut Mérieux
- National Institutes of Health (CA006973, DK089502)
- Johns Hopkins Bloomberg School of Public Health
- Sidney Kimmel Comprehensive Cancer Center (P30 CA006973, CA006973)
- National Cancer Institute (T32CA126607, R21CA170492, U54CA091409, R01CA151393, P30CA021765, P30CA006973)
- National Institute of Allergy and Infectious Diseases (T32AI007417)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK089502, K08DK087856)
- National Institute of Dental and Craniofacial Research (R01DE022586)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colorectal cancer, colonic microbiota, bacterial biofilms, proximal colorectal cancer, right-sided tumors, E-cadherin, interleukin-6, STAT3 signaling, colorectal adenoma, cancer risk prediction, environmental risk factors
- MeSH terms
- Bacteria, Colonoscopy, Humans, Colorectal Neoplasms, Biofilms, Microbiota
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