McDonald, Jeffrey G.

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism

Drug Transport and Resistance MechanismsFibroblast Growth Factor Research

Cited by 1,865

25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon

Reboldi, A., Dang, E. V., McDonald, J. G., Liang, G., Russell, D. W., & Cyster, J. G. (2014) · Science

interferon and immune responsesInflammasome and immune disorders

Cited by 444

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 443

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., et al. (2019) · Immunity

Liver physiology and pathologyImmune cells in cancer

Cited by 418

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

Gorden, D. L., Myers, D. S., Ivanova, P. T., Fahy, E., Maurya, M. R., Gupta, S., Min, J., Spann, N. J., McDonald, J. G., Kelly, S. L., et al. (2015) · Journal of Lipid Research

Liver Disease Diagnosis and TreatmentMetabolomics and Mass Spectrometry Studies

Cited by 372

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Dang, E. V., McDonald, J. G., Russell, D. W., & Cyster, J. G. (2017) · Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 348

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

Bauman, D. R., Bitmansour, A. D., McDonald, J. G., Thompson, B. M., Liang, G., & Russell, D. W. (2009) · Proceedings of the National Academy of Sciences

Immune Response and InflammationCholesterol and Lipid Metabolism

Cited by 329

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

Buchovecky, C. M., Turley, S. D., Brown, H. M., Kyle, S. M., McDonald, J. G., Liu, B., Pieper, A. A., Huang, W., Katz, D. M., Russell, D. W., et al. (2013) · Nature Genetics

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 234

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

Rong, S., Cortés, V. A., Rashid, S., Anderson, N. N., McDonald, J. G., Liang, G., Moon, Y.-A., Hammer, R. E., & Horton, J. D. (2017) · eLife

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 134

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Trinh, M. N., Brown, M. S., Goldstein, J. L., Han, J., Vale, G., McDonald, J. G., Seemann, J., Mendell, J. T., & Lu, F. (2020) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Cited by 129

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER

Rong, S., Xia, M., Vale, G., Wang, S., Kim, C.-W., Li, S., McDonald, J. G., Radhakrishnan, A., & Horton, J. D. (2024) · Cell Metabolism

Lipid metabolism and biosynthesisLiver Disease Diagnosis and Treatment

Cited by 102

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Long, T., Hassan, A., Thompson, B. M., McDonald, J. G., Wang, J., & Li, X. (2019) · Nature Communications

Cholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Cited by 65

Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol

Trinh, M. N., Brown, M. S., Seemann, J., Vale, G., McDonald, J. G., Goldstein, J. L., & Lu, F. (2022) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Cited by 42

Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake

Long, T., Li, D., Vale, G., Jiang, Y., Schmiege, P., Yang, Z. J., McDonald, J. G., & Li, X. (2024) · Cell

Cholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Cited by 31

Molecular insights into human phosphatidylserine synthase 2 and its regulation of SREBP pathways

Li, D., Chen, H., Vale, G., Elghobashi-Meinhardt, N., Hatton, A., Rong, S., McDonald, J. G., & Li, X. (2025) · Proceedings of the National Academy of Sciences

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 6