Wirtz, Denis

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 1,520

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

Agarwal, A., Wu, P.-H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D., & Bergles, D. E. (2017) · Neuron

Mitochondrial Function and PathologyNeuroscience and Neuropharmacology Research

Cited by 441

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 437

RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 296

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 252

CODA: quantitative 3D reconstruction of large tissues at cellular resolution

Kiemen, A. L., Braxton, A. M., Grahn, M. P., Han, K. S., Babu, J. M., Reichel, R., Jiang, A. C., Kim, B., Hsu, J., Amoa, F., et al. (2022) · Nature Methods

Cell Image Analysis TechniquesAI in cancer detection

Cited by 218

RETRACTED: Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

Gilkes, D. M., Xiang, L., Lee, S. J., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCancer, Hypoxia, and Metabolism

Cited by 184

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Jayatilaka, H., Tyle, P., Chen, J. J., Kwak, M., Ju, J., Kim, H. J., Lee, J. S. H., Wu, P.-H., Gilkes, D. M., Fan, R., et al. (2017) · Nature Communications

Chemokine receptors and signalingCancer Cells and Metastasis

Cited by 177

Single-cell morphology encodes metastatic potential

Wu, P.-H., Gilkes, D. M., Phillip, J. M., Narkar, A., Cheng, T. W.-T., Marchand, J., Lee, M.-H., Li, R., & Wirtz, D. (2020) · Science Advances

Cancer Cells and MetastasisCell Image Analysis Techniques

Cited by 177

Evolution of cellular morpho-phenotypes in cancer metastasis.

Wu, P.-H., Phillip, J. M., Khatau, S. B., Chen, W.-C., Stirman, J., Rosseel, S., Tschudi, K., Van Patten, J., Wong, M., Gupta, S., et al. (2015) · Scientific Reports

Cell Image Analysis TechniquesCancer Cells and Metastasis

Cited by 117

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single‐cell resolution

Chambliss, A. B., Wu, P., Chen, W., Sun, S. X., & Wirtz, D. (2013) · The FASEB Journal

Cell Image Analysis TechniquesAdvanced Fluorescence Microscopy Techniques

Cited by 34

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction

Neri, F., Zheng, S., Watson, M. A., Desprez, P.-Y., Gerencser, A. A., Campisi, J., Wirtz, D., Wu, P.-H., & Schilling, B. (2025) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 6