LoGrasso, Philip

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

Grassi, D., Howard, S., Zhou, M., Diaz-Perez, N., Urban, N. T., Guerrero-Given, D., Kamasawa, N., Volpicelli-Daley, L. A., LoGrasso, P., & Lasmézas, C. I. (2018) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 228

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

Chambers, J. W., & LoGrasso, P. V. (2011) · Journal of Biological Chemistry

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 194

The Structure of JNK3 in Complex with Small Molecule Inhibitors

Scapin, G., Patel, S. B., Lisnock, J., Becker, J. W., & LoGrasso, P. V. (2003) · Chemistry & Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 131

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow‐Derived Mouse Mesenchymal Stem Cells via a p53‐Dependent Mechanism: Implications for Long‐Term Culture Expansion

Boregowda, S. V., Krishnappa, V., Chambers, J. W., Lograsso, P. V., Lai, W., Ortiz, L. A., & Phinney, D. G. (2012) · STEM CELLS

Mesenchymal stem cell researchHematopoietic Stem Cell Transplantation

Cited by 114

Activation of JNK3α1 Requires both MKK4 and MKK7: Kinetic Characterization of in Vitro Phosphorylated JNK3α1

Lisnock, J., Griffin, P., Calaycay, J., Frantz, B., Parsons, J., O'Keefe, S. J., & LoGrasso, P. (2000) · Biochemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 79

Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases

Laughlin, J. D., Nwachukwu, J. C., Figuera-Losada, M., Cherry, L., Nettles, K. W., & LoGrasso, P. V. (2012) · Structure

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 50

Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway

Iqbal, S., Howard, S., & LoGrasso, P. V. (2015) · Molecular and Cellular Biology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 23

Kinetic Mechanism and Inhibitor Characterization for c-jun-N-Terminal Kinase 3α1

Ember, B., Kamenecka, T., & LoGrasso, P. (2008) · Biochemistry

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 22