Jacobs, William R.

inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis

Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K. S., Wilson, T., Collins, D., de Lisle, G., & Jacobs, W. R. (1994) · Science

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 1,389

The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

Hsu, T., Hingley-Wilson, S. M., Chen, B., Chen, M., Dai, A. Z., Morin, P. M., Marks, C. B., Padiyar, J., Goulding, C., Gingery, M., et al. (2003) · Proceedings of the National Academy of Sciences

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 731

Lysogeny and transformation in mycobacteria: stable expression of foreign genes.

Snapper, S. B., Lugosi, L., Jekkel, A., Melton, R. E., Kieser, T., Bloom, B. R., & Jacobs, W. R. (1988) · Proceedings of the National Academy of Sciences

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 326

Introduction of foreign DNA into mycobacteria using a shuttle phasmid

Jacobs, W. R., Tuckman, M., & Bloom, B. R. (1987) · Nature

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 314

Altered NADH/NAD + Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria

Vilchèze, C., Weisbrod, T. R., Chen, B., Kremer, L., Hazbón, M. H., Wang, F., Alland, D., Sacchettini, J. C., & Jacobs, W. R. (2005) · Antimicrobial Agents and Chemotherapy

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 284

An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning

Hanauer, D. I., Graham, M. J., SEA-PHAGES, Betancur, L., Bobrownicki, A., Cresawn, S. G., Garlena, R. A., Jacobs-Sera, D., Kaufmann, N., Pope, W. H., et al. (2017) · Proceedings of the National Academy of Sciences

Science Education and PedagogyCareer Development and Diversity

Cited by 217

Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence

Tufariello, J. M., Chapman, J. R., Kerantzas, C. A., Wong, K.-W., Vilchèze, C., Jones, C. M., Cole, L. E., Tinaztepe, E., Thompson, V., Fenyö, D., et al. (2016) · Proceedings of the National Academy of Sciences

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 215

Mycobacterium tuberculosis ΔRD1 ΔpanCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis

Sambandamurthy, V. K., Derrick, S. C., Hsu, T., Chen, B., Larsen, M. H., Jalapathy, K. V., Chen, M., Kim, J., Porcelli, S. A., Chan, J., et al. (2006) · Vaccine

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 213

NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis

Miesel, L., Weisbrod, T. R., Marcinkeviciene, J. A., Bittman, R., & Jacobs, W. R. (1998) · Journal of Bacteriology

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 155

Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

Sampson, S. L., Dascher, C. C., Sambandamurthy, V. K., Russell, R. G., Jacobs, W. R., Bloom, B. R., & Hondalus, M. K. (2004) · Infection and Immunity

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 153

Mycobacterium smegmatis: The Vanguard of Mycobacterial Research

Sparks, I. L., Derbyshire, K. M., Jacobs, W. R., & Morita, Y. S. (2023) · Journal of Bacteriology

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 149

An obligately aerobic soil bacterium activates fermentative hydrogen production to survive reductive stress during hypoxia

Berney, M., Greening, C., Conrad, R., Jacobs, W. R., & Cook, G. M. (2014) · Proceedings of the National Academy of Sciences

Metalloenzymes and iron-sulfur proteinsBacterial Genetics and Biotechnology

Cited by 142

Two Nonredundant SecA Homologues Function in Mycobacteria

Braunstein, M., Brown, A. M., Kurtz, S., & Jacobs, W. R. (2001) · Journal of Bacteriology

Bacterial Genetics and BiotechnologyTuberculosis Research and Epidemiology

Cited by 141

Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis

Sambandamurthy, V. K., Derrick, S. C., Jalapathy, K. V., Chen, B., Russell, R. G., Morris, S. L., & Jacobs, W. R. (2005) · Infection and Immunity

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 138

Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis

Vilchèze, C., Molle, V., Carrère-Kremer, S., Leiba, J., Mourey, L., Shenai, S., Baronian, G., Tufariello, J., Hartman, T., Veyron-Churlet, R., et al. (2014) · PLoS Pathogens

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 76

Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids

Panas, M. W., Jain, P., Yang, H., Mitra, S., Biswas, D., Wattam, A. R., Letvin, N. L., & Jacobs, W. R. (2014) · Proceedings of the National Academy of Sciences

Bacterial Genetics and BiotechnologyTuberculosis Research and Epidemiology

Cited by 62

Mycobacteriophage Vector Systems

Jacobs, W. R., Snapper, S. B., Tuckman, M., & Bloom, B. R. (1989) · Clinical Infectious Diseases

Bacterial Genetics and BiotechnologyTuberculosis Research and Epidemiology

Cited by 48

Sulfite Reduction in Mycobacteria

Pinto, R., Harrison, J. S., Hsu, T., Jacobs, W. R., & Leyh, T. S. (2007) · Journal of Bacteriology

Tuberculosis Research and EpidemiologyMetalloenzymes and iron-sulfur proteins

Cited by 46

Addressing the Metabolic Stability of Antituberculars through Machine Learning

Stratton, T. P., Perryman, A. L., Vilchèze, C., Russo, R., Li, S.-G., Patel, J. S., Singleton, E., Ekins, S., Connell, N., Jacobs, W. R., et al. (2017) · ACS Medicinal Chemistry Letters

Computational Drug Discovery MethodsPharmacogenetics and Drug Metabolism

Cited by 14