Masters, Seth L.

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature

Immune Response and InflammationImmune cells in cancer

Cited by 4,176

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,849

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology

Inflammasome and immune disordersPancreatic function and diabetes

Cited by 1,330

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Mridha, A. R., Wree, A., Robertson, A. A. B., Yeh, M. M., Johnson, C. D., Van Rooyen, D. M., Haczeyni, F., Teoh, N. C.-H., Savard, C., Ioannou, G. N., et al. (2017) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentInflammasome and immune disorders

Cited by 1,110

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Yu, C.-H., Davidson, S., Harapas, C. R., Hilton, J. B., Mlodzianoski, M. J., Laohamonthonkul, P., Louis, C., Low, R. R. J., Moecking, J., De Nardo, D., et al. (2020) · Cell

Amyotrophic Lateral Sclerosis Researchinterferon and immune responses

Cited by 1,019

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Conos, S. A., Chen, K. W., De Nardo, D., Hara, H., Whitehead, L., Núñez, G., Masters, S. L., Murphy, J. M., Schroder, K., Vaux, D. L., et al. (2017) · Proceedings of the National Academy of Sciences

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 485

Homeostasis-altering molecular processes as mechanisms of inflammasome activation

Liston, A., & Masters, S. L. (2017) · Nature Reviews Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 459

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Zhong, F. L., Mamaï, O., Sborgi, L., Boussofara, L., Hopkins, R., Robinson, K., Szeverényi, I., Takeichi, T., Balaji, R., Lau, A., et al. (2016) · Cell

Inflammasome and immune disordersGenetic and rare skin diseases.

Cited by 440

The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages

Uwamahoro, N., Verma-Gaur, J., Shen, H.-H., Qu, Y., Lewis, R., Lu, J., Bambery, K., Masters, S. L., Vince, J. E., Naderer, T., et al. (2014) · mBio

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 264

Inflammasome Priming in Sterile Inflammatory Disease

Patel, M. N., Carroll, R. G., Galván-Peña, S., Mills, E. L., Olden, R., Triantafilou, M., Wolf, A. I., Bryant, C. E., Triantafilou, K., & Masters, S. L. (2017) · Trends in Molecular Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 241

The Inflammasome in Atherosclerosis and Type 2 Diabetes

Masters, S. L., Latz, E., & O’Neill, L. A. J. (2011) · Science Translational Medicine

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 169

ATF3 Is a Key Regulator of Macrophage IFN Responses

Labzin, L. I., Schmidt, S. V., Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lütjohann, D., Schultze, J. L., Latz, E., et al. (2015) · The Journal of Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 124

The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration

Jackson, J. T., Mulazzani, E., Nutt, S. L., & Masters, S. L. (2021) · Journal of Biological Chemistry

Immunodeficiency and Autoimmune DisordersProtein Kinase Regulation and GTPase Signaling

Cited by 113

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS

Eitan, C., Siany, A., Barkan, E., Olender, T., van Eijk, K. R., Moisse, M., Farhan, S. M. K., Danino, Y. M., Yanowski, E., Marmor-Kollet, H., et al. (2022) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 38