Inflammasome Priming in Sterile Inflammatory Disease

A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Inflammasomes: mechanism of action, role in disease, and therapeutics

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Mechanism and Regulation of NLRP3 Inflammasome Activation

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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

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Inflammatory caspases are innate immune receptors for intracellular LPS

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

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Immunometabolism governs dendritic cell and macrophage function

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The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

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Therapeutic targeting of microRNAs: current status and future challenges

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Sensing and reacting to microbes through the inflammasomes

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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

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Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

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NLRP3 inflammasome and its inhibitors: a review

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Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

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Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

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TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

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Inflammasome is a central player in the induction of obesity and insulin resistance

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Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

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Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

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Adipokines Mediate Inflammation and Insulin Resistance

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

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Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

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SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

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Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

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Lipid homeostasis, lipotoxicity and the metabolic syndrome

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Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

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Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies

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An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

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Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

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FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

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Caspase-11 Protects Against Bacteria That Escape the Vacuole

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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

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Circulating Oxidized LDL Is a Useful Marker for Identifying Patients With Coronary Artery Disease

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The Membrane Attack Complex of Complement

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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

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Inflammasomes in liver diseases

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NLRP3 inflammasome activation is required for fibrosis development in NAFLD

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NLRP3 inflammasome activity is negatively controlled by miR-223

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Detection and localization of tumor necrosis factor in human atheroma

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Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB

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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

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Effects of ACL Reconstructive Surgery on Temporal Variations of Cytokine Levels in Synovial Fluid

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The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling

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ER stress induces NLRP3 inflammasome activation and hepatocyte death

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MicroRNA therapeutics: Discovering novel targets and developing specific therapy

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Complement membrane attack on nucleated cells: resistance, recovery and non-lethal effects

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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

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Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells

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NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5

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The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

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Molecular mechanisms involved in inflammasome activation

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Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

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Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

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Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes

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Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis

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The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort

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IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

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C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

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Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

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Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

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LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

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Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway

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Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature

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Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis

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Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment

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Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target

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Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

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Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns

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Inflammatory Diseases and Vitamin E—What Do We Know and Where Do We Go?

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Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis

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Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis

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α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome

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Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation

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Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update

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Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome

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Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function

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Alcohol accumulation promotes esophagitis via pyroptosis activation

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IL-23/IL-17 Axis Activates IL-1β-Associated Inflammasome in Macrophages and Generates an Auto-Inflammatory Response in a Subgroup of Patients With Bullous Pemphigoid

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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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Icaritin Provides Neuroprotection in Parkinson’s Disease by Attenuating Neuroinflammation, Oxidative Stress, and Energy Deficiency

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NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection

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Limonin Inhibits IL‐1β‐Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2

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COPs and POPs Patrol Inflammasome Activation

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Natural products in attenuating renal inflammation via inhibiting the NLRP3 inflammasome in diabetic kidney disease

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Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

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NLRP3 in somatic non-immune cells of rodent and primate testes

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Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

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Effects of phosphorylation on the NLRP3 inflammasome

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Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A

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Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity

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The H240R Protein of African Swine Fever Virus Inhibits Interleukin 1β Production by Inhibiting NEMO Expression and NLRP3 Oligomerization

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Huanglian-Wendan Decoction Inhibits NF-κB/NLRP3 Inflammasome Activation in Liver and Brain of Rats Exposed to Chronic Unpredictable Mild Stress

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NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity

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Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome

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Atherosclerosis and Its Related Laboratory Biomarkers

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Macrophage NLRP3 inflammasome activated by CVB3 capsid proteins contributes to the development of viral myocarditis

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NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet

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Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy

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Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity

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Apoptosis‐associated speck‐like protein containing a caspase‐1 recruitment domain (ASC) contributes to osteoblast differentiation and osteogenesis

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The NLRP1 inflammasome in skin diseases

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Podocyte NADPH Oxidase 5 Promotes Renal Inflammation Regulated by the Toll-Like Receptor Pathway

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Aggregation Susceptibility of Low-Density Lipoproteins—A Novel Modifiable Biomarker of Cardiovascular Risk

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Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages

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IL-37 alleviates Coxsackievirus B3-induced viral myocarditis via inhibiting NLRP3 inflammasome-mediated pyroptosis

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Mesenchymal stem cells inhibited the apoptosis of alveolar epithelial cells caused by ARDS through CXCL12/CXCR4 axis

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Nlrp3 Inflammasome Inhibitor MCC950 Ameliorates Obliterative Bronchiolitis by Inhibiting Th1/Th17 Response and Promoting Treg Response After Orthotopic Tracheal Transplantation in Mice

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