Mazzone, Massimiliano

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Pennacchietti, S., Michieli, P., Galluzzo, M., Mazzone, M., Giordano, S., & Comoglio, P. M. (2003) · Cancer Cell

Cancer, Hypoxia, and MetabolismLiver physiology and pathology

Cited by 1,311

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 1,264

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

Rolny, C., Mazzone, M., Tugues, S., Laoui, D., Johansson, I., Coulon, C., Squadrito, M. L., Segura, I., Li, X., Knevels, E., et al. (2011) · Cancer Cell

Immune cells in cancerAngiogenesis and VEGF in Cancer

Cited by 695

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

Thienpont, B., Steinbacher, J., Zhao, H., D’Anna, F., Kuchnio, A., Ploumakis, A., Ghesquière, B., Van Dyck, L., Boeckx, B., Schoonjans, L., et al. (2016) · Nature

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

Cited by 635

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

Wenes, M., Shang, M., Di Matteo, M., Goveia, J., Martín-Pérez, R., Serneels, J., Prenen, H., Ghesquière, B., Carmeliet, P., & Mazzone, M. (2016) · Cell Metabolism

Immune cells in cancerAngiogenesis and VEGF in Cancer

Cited by 496

Mitochondria metabolism sets the species-specific tempo of neuronal development

Iwata, R., Casimir, P., Erkol, E., Boubakar, L., Planque, M., Gallego López, I. M., Ditkowska, M., Gaspariunaite, V., Beckers, S., Remans, D., et al. (2023) · Science

Neurogenesis and neuroplasticity mechanismsMitochondrial Function and Pathology

Cited by 312

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews

Cancer, Hypoxia, and MetabolismCancer Immunotherapy and Biomarkers

Cited by 310

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

De Bock, K., Mazzone, M., & Carmeliet, P. (2011) · Nature Reviews Clinical Oncology

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 293

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

Verbeke, L., Mannaerts, I., Schierwagen, R., Govaere, O., Klein, S., Vander Elst, I., Windmolders, P., Farre, R., Wenes, M., Mazzone, M., et al. (2016) · Scientific Reports

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 236

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Goveia, J., Rohlenova, K., Taverna, F., Treps, L., Conradi, L.-C., Pircher, A., Geldhof, V., de Rooij, L. P. M. H., Kalucka, J., Sokol, L., et al. (2020) · Cancer Cell

Angiogenesis and VEGF in CancerSingle-cell and spatial transcriptomics

Cited by 125

The mTOR and PP2A pathways regulate PHD2 phosphorylation to fine-tune HIF1α levels and colorectal cancer cell survival under hypoxia

Di Conza, G., Trusso Cafarello, S., Loroch, S., Mennerich, D., Deschoemaeker, S., Di Matteo, M., Ehling, M., Gevaert, K., Prenen, H., Zahedi, R. P., et al. (2017) · Cell Reports

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 119

Identification of a chronic non‐neurodegenerative microglia activation state in a mouse model of peroxisomal β‐oxidation deficiency

Verheijden, S., Beckers, L., Casazza, A., Butovsky, O., Mazzone, M., & Baes, M. (2015) · Glia

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 40

Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection

Phan, Q. T., Solis, N. V., Cravener, M. V., Swidergall, M., Lin, J., Huang, M. Y., Liu, H., Singh, S., Ibrahim, A. S., Mazzone, M., et al. (2023) · PLOS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 29