Cited by 293Angiogenesis and VEGF in CancerCancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

De Bock, Katrien, Mazzone, Massimiliano, Carmeliet, Peter·2011·Nature Reviews Clinical Oncology

Abstract

All human cells, including cancer cells, need oxygen and nutrients to survive. A widely used strategy to combat cancer is therefore the starvation of tumor cells by cutting off the blood supply of tumors. Clinical experience indeed shows that tumor progression can be delayed by anti-angiogenic agents. However, emerging evidence indicates that in certain experimental conditions, hypoxia as a result of pruning of the tumor microvasculature can promote tumor invasion and metastasis, although these findings are contextual and debated. Genetic studies in mice unveiled that vascular-targeting strategies that avoid aggravation of tumor hypoxia or even promote tumor oxygenation might prevent such an invasive metastatic switch. In this article, we will discuss the emerging link between hypoxia signaling and the various steps of metastasis.

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Crossref · 10.1038/nrclinonc.2011.83

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149 of 149 references verified0 citation errors · 0 not checkable

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  • Hypoxia and activation of HIF signaling influence multiple steps within the metastatic cascade, including invasion and migration, intravasation and extravasation, establishment of the premetastatic niche, and survival and growth at the distant site.

    “Hypoxia and activation of HIF signaling influence multiple steps within the metastatic cascade, including invasion and migration, intravasation and extravasation, and establishment of the premetastatic niche, as well as survival and growth at the distant site”

    From Hypoxic control of metastasis (2016) · cites this paper as [48]

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Authors
De Bock, K., Mazzone, M., & Carmeliet, P.
Affiliations
KU Leuven (BE)
Corresponding author
Carmeliet, Peter
Venue
Nature Reviews Clinical Oncology
Published
2011-05-31
Volume
8
Issue
7
Pages
393-404
ISSN
  • 1759-4774 (ISSN-L)
  • 1759-4782
OpenAlex
W1989402742
Cited by
293
References
149
Citations by year
2026: 8 · 2025: 7 · 2024: 13 · 2023: 17 · 2022: 19 · 2021: 24 · 2020: 20 · 2019: 12 · 2018: 17 · 2017: 15 · 2016: 20 · 2015: 31 · 2014: 30 · 2013: 31 · 2012: 27
FWCI
2.61
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
anti-angiogenic therapy, tumor hypoxia, metastasis, tumor invasion, hypoxia signaling, tumor microvasculature, tumor oxygenation, vascular targeting agents, tumor starvation
MeSH terms
Animals, Hypoxia, Humans, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Angiogenesis Inhibitors, Mice

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