Koo, Bon-Kyoung

Human organoids: model systems for human biology and medicine

Kim, J., Koo, B.-K., & Knoblich, J. A. (2020) · Nature Reviews Molecular Cell Biology

Pluripotent Stem Cells Research3D Printing in Biomedical Research

Cited by 2,187

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Broutier, L., Mastrogiovanni, G., Verstegen, M. M., Francies, H. E., Gavarró, L. M., Bradshaw, C. R., Allen, G. E., Arnes-Benito, R., Sidorova, O., Gaspersz, M. P., et al. (2017) · Nature Medicine

Cancer Cells and MetastasisHepatocellular Carcinoma Treatment and Prognosis

Cited by 1,471

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Schwank, G., Koo, B.-K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C. K., et al. (2013) · Cell Stem Cell

CRISPR and Genetic EngineeringCystic Fibrosis Research Advances

Cited by 1,424

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

Broutier, L., Andersson-Rolf, A., Hindley, C. J., Boj, S. F., Clevers, H., Koo, B.-K., & Huch, M. (2016) · Nature Protocols

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 834

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B.-K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H., & Clevers, H. (2012) · Nature Methods

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 320

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

Heijmans, J., van Lidth de Jeude, J. F., Koo, B.-K., Rosekrans, S. L., Wielenga, M. C. B., van de Wetering, M., Ferrante, M., Lee, A. S., Onderwater, J. J. M., Paton, J. C., et al. (2013) · Cell Reports

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 293

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts

Schuijers, J., Junker, J. P., Mokry, M., Hatzis, P., Koo, B.-K., Sasselli, V., van der Flier, L. G., Cuppen, E., van Oudenaarden, A., & Clevers, H. (2015) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 273

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

Kim, H.-A., Koo, B.-K., Cho, J.-H., Kim, Y.-Y., Seong, J., Chang, H. J., Oh, Y. M., Stange, D. E., Park, J.-G., Hwang, D., et al. (2012) · Journal of Clinical Investigation

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 139

Tracing oncogene-driven remodelling of the intestinal stem cell niche

Yum, M. K., Han, S., Fink, J., Wu, S.-H. S., Dabrowska, C., Trendafilova, T., Mustata, R., Chatzeli, L., Azzarelli, R., Pshenichnaya, I., et al. (2021) · Nature

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 114

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

Belenguer, G., Mastrogiovanni, G., Pacini, C., Hall, Z., Dowbaj, A. M., Arnes-Benito, R., Sljukic, A., Prior, N., Kakava, S., Bradshaw, C. R., et al. (2022) · Nature Communications

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 71

Genetic engineering in organoids

Teriyapirom, I., Batista-Rocha, A. S., & Koo, B.-K. (2021) · Journal of Molecular Medicine

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 68

Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss

Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, B.-K., Dollé, P., Bloch-Zupan, A., et al. (2020) · Scientific Reports

Bone and Dental Protein Studiesdental development and anomalies

Cited by 25