Huitinga, Inge

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Chen, W.-T., Lu, A., Craessaerts, K., Pavie, B., Sala Frigerio, C., Corthout, N., Qian, X., Laláková, J., Kühnemund, M., Voytyuk, I., et al. (2020) · Cell

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 949

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages

Huitinga, I., van Rooijen, N., de Groot, C. J., Uitdehaag, B. M., & Dijkstra, C. D. (1990) · The Journal of experimental medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 506

Tissue-resident memory T cells populate the human brain

Smolders, J., Heutinck, K. M., Fransen, N. L., Remmerswaal, E. B. M., Hombrink, P., ten Berge, I. J. M., van Lier, R. A. W., Huitinga, I., & Hamann, J. (2018) · Nature Communications

T-cell and B-cell ImmunologyNeuroinflammation and Neurodegeneration Mechanisms

Cited by 406

Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis

Luchetti, S., Fransen, N. L., van Eden, C. G., Ramaglia, V., Mason, M., & Huitinga, I. (2018) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 355

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

Hendrickx, D. A. E., van Eden, C. G., Schuurman, K. G., Hamann, J., & Huitinga, I. (2017) · Journal of Neuroimmunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 313

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Schlaphoff, L., Depp, C., Düking, T., Winchenbach, J., Neuber, J., Ewers, D., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 307

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

van der Poel, M., Ulas, T., Mizee, M. R., Hsiao, C.-C., Miedema, S. S. M., Adelia, Schuurman, K. G., Helder, B., Tas, S. W., Schultze, J. L., et al. (2019) · Nature Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 306

Locus for severity implicates CNS resilience in progression of multiple sclerosis

International Multiple Sclerosis Genetics Consortium, Harroud, A., Stridh, P., McCauley, J. L., Saarela, J., van den Bosch, A. M. R., Engelenburg, H. J., Beecham, A. H., Alfredsson, L., Alikhani, K., et al. (2023) · Nature

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 243

Effects of Antemortem and Postmortem Variables on Human Brain mRNA Quality: A BrainNet Europe Study

Durrenberger, P. F., Fernando, S., Kashefi, S. N., Ferrer, I., Hauw, J.-J., Seilhean, D., Smith, C., Walker, R., Al-Sarraj, S., Troakes, C., et al. (2010) · Journal of Neuropathology & Experimental Neurology

Molecular Biology Techniques and ApplicationsRNA Research and Splicing

Cited by 161

Phenotyping primary human microglia: tight regulation of LPS responsiveness

Melief, J., Koning, N., Schuurman, K. G., Van De Garde, M. D. B., Smolders, J., Hoek, R. M., Van Eijk, M., Hamann, J., & Huitinga, I. (2012) · Glia

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 146

Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

Hendrickx, D. A. E., van Scheppingen, J., van der Poel, M., Bossers, K., Schuurman, K. G., van Eden, C. G., Hol, E. M., Hamann, J., & Huitinga, I. (2017) · Frontiers in Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 139

West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice

Ben-Nathan, D., Huitinga, I., Lustig, S., van Rooijen, N., & Kobiler, D. (1996) · Archives of Virology

Mosquito-borne diseases and controlViral Infections and Vectors

Cited by 138

Impaired hypothalamus-pituitary-adrenal axis activity and more severe multiple sclerosis with hypothalamic lesions

Huitinga, I., Erkut, Z. A., van Beurden, D., & Swaab, D. F. (2004) · Annals of Neurology

Multiple Sclerosis Research StudiesStress Responses and Cortisol

Cited by 126

Hypothalamic lesions in multiple sclerosis

Huitinga, I., De Groot, C. J. A., Van der Valk, P., Kamphorst, W., Tilders, F. J. H., & Swaab, D. F. (2001) · Journal of Neuropathology & Experimental Neurology

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 120

Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease

Wirths, O., Erck, C., Martens, H., Harmeier, A., Geumann, C., Jawhar, S., Kumar, S., Multhaup, G., Walter, J., Ingelsson, M., et al. (2010) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 103

GPCRomics of homeostatic and disease-associated human microglia

Hsiao, C.-C., Sankowski, R., Prinz, M., Smolders, J., Huitinga, I., & Hamann, J. (2021) · Frontiers in Immunology

Neuroinflammation and Neurodegeneration MechanismsReceptor Mechanisms and Signaling

Cited by 59

Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Böttcher, C., van der Poel, M., Fernández-Zapata, C., Schlickeiser, S., Leman, J. K. H., Hsiao, C.-C., Mizee, M. R., Adelia, Vincenten, M. C. J., Kunkel, D., et al. (2020) · Acta Neuropathologica Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 58

Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage

van den Bosch, A., Fransen, N., Mason, M., Rozemuller, A. J., Teunissen, C., Smolders, J., & Huitinga, I. (2022) · Neurology Neuroimmunology & Neuroinflammation

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 58

Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features

Zhang, L., Verwer, R. W. H., Zhao, J., Huitinga, I., Lucassen, P. J., & Swaab, D. F. (2021) · Journal of Affective Disorders

Treatment of Major DepressionTryptophan and brain disorders

Cited by 40

Post‐mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms

Fransen, N. L., Crusius, J. B. A., Smolders, J., Mizee, M. R., van Eden, C. G., Luchetti, S., Remmerswaal, E. B. M., Hamann, J., Mason, M. R. J., & Huitinga, I. (2020) · Brain Pathology

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 37

Stress-Axis Regulation by Vitamin D3 in Multiple Sclerosis

Rolf, L., Damoiseaux, J., Huitinga, I., Kimenai, D., van den Ouweland, J., Hupperts, R., & Smolders, J. (2018) · Frontiers in Neurology

Vitamin D Research StudiesMultiple Sclerosis Research Studies

Cited by 28

Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis

Chen, J. Q. A., McNamara, N. B., Engelenburg, H. J., Jongejan, A., Wever, D. D., Hopman, K., van Rixel, E., Nijhuis, P. J. H., de Winter, F., Moerland, P. D., et al. (2025) · Brain

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 17

Foamy microglia link oxylipins to disease progression in multiple sclerosis

van der Vliet, D., Di, X., Shamorkina, T. M., Coulon-Bainier, C., Pavlovic, A., van der Vliet, I. A. C. M., Zeng, Y., Macnair, W., van Egmond, N., Chen, J. Q. A., et al. (2026) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 9

Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis

Chen, J. Q. A., Wever, D. D., McNamara, N. B., Bourik, M., Smolders, J., Hamann, J., & Huitinga, I. (2025) · Frontiers in Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 9