Wren, Jonathan D.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,584

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., et al. (2016) · Aging Cell

Telomeres, Telomerase, and SenescenceCell death mechanisms and regulation

Cited by 1,148

Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

Tucsek, Z., Toth, P., Tarantini, S., Sosnowska, D., Gautam, T., Warrington, J. P., Giles, C. B., Wren, J. D., Koller, A., Ballabh, P., et al. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Barrier Structure and Function StudiesNeurological Disease Mechanisms and Treatments

Cited by 191

PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity

Iwayama, T., Steele, C., Yao, L., Dozmorov, M. G., Karamichos, D., Wren, J. D., & Olson, L. E. (2015) · Genes & Development

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 164

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection

Toth, P., Tarantini, S., Springo, Z., Tucsek, Z., Gautam, T., Giles, C. B., Wren, J. D., Koller, A., Sonntag, W. E., Csiszar, A., et al. (2015) · Aging Cell

Intracerebral and Subarachnoid Hemorrhage ResearchNeurological Disease Mechanisms and Treatments

Cited by 163

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., et al. (2020) · GeroScience

Sirtuins and Resveratrol in MedicineNeurological Disease Mechanisms and Treatments

Cited by 163

Profiling of m6A RNA modifications identified an age‐associated regulation of AGO 2 mRNA stability

Min, K., Zealy, R. W., Davila, S., Fomin, M., Cummings, J. C., Makowsky, D., Mcdowell, C. H., Thigpen, H., Hafner, M., Kwon, S., et al. (2018) · Aging Cell

RNA modifications and cancerRNA regulation and disease

Cited by 131

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini, S., Tucsek, Z., Valcarcel-Ares, M. N., Toth, P., Gautam, T., Giles, C. B., Ballabh, P., Wei, J. Y., Wren, J. D., Ashpole, N. M., et al. (2016) · AGE

Neurological Disease Mechanisms and TreatmentsBarrier Structure and Function Studies

Cited by 98

A global meta-analysis of microarray expression data to predict unknown gene functions and estimate the literature-data divide

Wren, J. D. (2009) · Bioinformatics

Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

Cited by 95

URL decay in MEDLINE—a 4-year follow-up study

Wren, J. D. (2008) · Bioinformatics

Web visibility and informetricsscientometrics and bibliometrics research

Cited by 85

Algorithmic identification of discrepancies between published ratios and their reported confidence intervals and P-values

Georgescu, C., & Wren, J. D. (2018) · Bioinformatics

Meta-analysis and systematic reviewsscientometrics and bibliometrics research

Cited by 20

A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity

Murach, K. A., Englund, D. A., Chambers, T. L., Dungan, C. M., Porter, H. L., Wren, J. D., Freeman, W. M., Dupont‐Versteegden, E. E., & Wen, Y. (2025) · The FASEB Journal

Muscle Physiology and DisordersEpigenetics and DNA Methylation

Cited by 12

Algorithmically outsourcing the detection of statistical errors and other problems.

Wren, J. D. (2018) · The EMBO Journal

Academic Writing and Publishingscientometrics and bibliometrics research

Cited by 6

Clinical trial IDs need to be validated prior to publication because hundreds of invalid National Clinical Trial Identifications are regularly entering MEDLINE

Wren, J. D. (2017) · Clinical Trials

Meta-analysis and systematic reviewsResearch Data Management Practices

Cited by 4