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Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline

Valcarcel‐Ares, M. N., Tucsek, Z., Kiss, T., Giles, C. B., Tarantini, S., Yabluchanskiy, A., Balasubramanian, P., Gautam, T., Galván, V., Ballabh, P., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly127 · Cited by 112 · see citing works

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Kiss, T., Giles, C. B., Tarantini, S., Yabluchanskiy, A., Balasubramanian, P., Gautam, T., Csípő, T., Nyúl‐Tóth, Á., Lipécz, Á., Szabó, C., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00095-x · Cited by 111 · see citing works

Shared relationship analysis: ranking set cohesion and commonalities within a literature-derived relationship network

Wren, J. D., & Garner, H. R. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg390 · Cited by 107 · see citing works

Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype

Tarantini, S., Valcarcel‐Ares, M. N., Yabluchanskiy, A., Springó, Z., Fülöp, G. Á., Ashpole, N. M., Gautam, T., Giles, C. B., Wren, J. D., Sonntag, W. E., et al. (2017) · Aging Cell · doi:10.1111/acel.12583 · Cited by 105 · see citing works

Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging

Tarantini, S., Yabluchanskiy, A., Csípő, T., Fülöp, G. Á., Kiss, T., Balasubramanian, P., DelFavero, J., Ahire, C., Ungvari, A., Nyúl‐Tóth, Á., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00101-2 · Cited by 104 · see citing works

Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis

Fonseca, R. S., Mahesula, S., Apple, D. M., Raghunathan, R., Dugan, A. M., Cardona, A. E., O’Connor, J. C., & Kokovay, E. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0319 · Cited by 101 · see citing works

Whole Brain Radiation-Induced Vascular Cognitive Impairment: Mechanisms and Implications

Warrington, J. P., Ashpole, N. M., Csiszár, A., Lee, Y. W., Ungvari, Z. I., & Sonntag, W. E. (2013) · Journal of Vascular Research · doi:10.1159/000354227 · Cited by 99 · see citing works

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini, S., Tucsek, Z., Valcarcel-Ares, M. N., Toth, P., Gautam, T., Giles, C. B., Ballabh, P., Wei, J. Y., Wren, J. D., Ashpole, N. M., et al. (2016) · AGE · doi:10.1007/s11357-016-9931-0 · Cited by 98 · see citing works

Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease

Csiszar, A., Tarantini, S., Fülöp, G. A., Kiss, T., Valcarcel-Ares, M. N., Galvan, V., Ungvari, Z., & Yabluchanskiy, A. (2017) · GeroScience · doi:10.1007/s11357-017-9991-9 · Cited by 93 · see citing works

Role of endothelial NAD+deficiency in age-related vascular dysfunction

Csiszár, A., Tarantini, S., Yabluchanskiy, A., Balasubramanian, P., Kiss, T., Farkas, E., Baur, J. A., & Ungvari, Z. I. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00039.2019 · Cited by 93 · see citing works

Dietary restriction involves NAD +‐dependent mechanisms and a shift toward oxidative metabolism

Moroz, N., Carmona, J. J., Anderson, E. N., Hart, A. C., Sinclair, D. A., & Blackwell, T. K. (2014) · Aging Cell · doi:10.1111/acel.12273 · Cited by 90 · see citing works

Endothelial dysfunction in aging animals: the role of poly(ADP‐ribose) polymerase activation

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Resveratrol Encapsulated in Novel Fusogenic Liposomes Activates Nrf2 and Attenuates Oxidative Stress in Cerebromicrovascular Endothelial Cells From Aged Rats

Csiszár, Á., Csiszár, A., Pinto, J. T., Gautam, T., Kleusch, C., Hoffmann, B., Tucsek, Z., Toth, P. P., Sonntag, W. E., & Ungvari, Z. I. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu029 · Cited by 85 · see citing works

NAD replenishment with nicotinamide mononucleotide protects blood–brain barrier integrity and attenuates delayed tissue plasminogen activator‐induced haemorrhagic transformation after cerebral ischaemia

Wei, C., Kong, Y., Hua, X., Li, G., Zheng, S., Cheng, M., Wang, P., & Miao, C. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13979 · Cited by 85 · see citing works

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

Quipildor, G. F., Mao, K., Hu, Z., Novaj, A., Cui, M., Gulinello, M. E., Branch, C. A., Gubbi, S., Patel, K., Moellering, D. R., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00065-3 · Cited by 85 · see citing works

Age-related decline in peripheral vascular health predicts cognitive impairment

Csípő, T., Lipécz, Á., Fülöp, G., Hand, R. A., Ngo, B.-T. N., Dzialendzik, M., Tarantini, S., Balasubramanian, P., Kiss, T., Yabluchanska, V., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00063-5 · Cited by 83 · see citing works

Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice

Fülöp, G., Ahire, C., Csípő, T., Tarantini, S., Kiss, T., Balasubramanian, P., Yabluchanskiy, A., Farkas, E., Tóth, A., Nyúl‐Tóth, Á., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00110-1 · Cited by 83 · see citing works

Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet

Bernier, M., Wahl, D., Ali, A., Allard, J. S., Faulkner, S., Wnorowski, A., Sanghvi, M., Moaddel, R., Alfaras, I., Mattison, J. A., et al. (2016) · Aging · doi:10.18632/aging.100942 · Cited by 63 · see citing works

Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice

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Circulating Factors Induced by Caloric Restriction in the Nonhuman Primate Macaca Mulatta Activate Angiogenic Processes in Endothelial Cells

Csiszár, A., Sosnowska, D., Tucsek, Z., Gautam, T., Toth, P. P., Losonczy, G., Colman, R. J., Weindruch, R. H., Anderson, R. M., Sonntag, W. E., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls158 · Cited by 58 · see citing works

Differences in the molecular structure of the blood-brain barrier in the cerebral cortex and white matter: an in silico, in vitro, and ex vivo study

Nyúl‐Tóth, Á., Suciu, M., Molnár, J., Fazakas, C., Haskó, J., Herman, H., Farkas, A. E., Kaszaki, J., Hermenean, A. O., Wilhelm, I., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00774.2015 · Cited by 57 · see citing works

Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3

Lopez‐Ramirez, M. A., Male, D. K., Wang, C., Sharrack, B., Wu, D., & Romero, I. A. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-27 · Cited by 56 · see citing works

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

Tarantini, S., Yabluchanksiy, A., Fülöp, G. Á., Hertelendy, P., Valcarcel‐Ares, M. N., Kiss, T., Bagwell, J. M., O’Connor, D., Farkas, E., Sorond, F. A., et al. (2017) · GeroScience · doi:10.1007/s11357-017-0003-x · Cited by 55 · see citing works

The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response

Chen, Y. X., Zhang, M., Cai, Y., Zhao, Q., & Dai, W. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.066 · Cited by 52 · see citing works

Systolic hypertension-induced neurovascular unit disruption magnifies vascular cognitive impairment in middle-age atherosclerotic LDLr−/−:hApoB+/+ mice

de Montgolfier, O., Pouliot, P., Gillis, M., Ferland, G., Lesage, F., Thorin‐Trescases, N., & Thorin, É. (2019) · GeroScience · doi:10.1007/s11357-019-00070-6 · Cited by 36 · see citing works

Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access

Imperio, C. G., McFalls, A. J., Colechio, E. M., Masser, D. R., Vrana, K. E., Grigson, P. S., & Freeman, W. M. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.12.005 · Cited by 31 · see citing works

Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging

Sorond, F. A., Whitehead, S. N., Arai, K., Arnold, D. L., Carmichael, S. T., DeCarli, C. S., Duering, M., Fornage, M., Flores‐Obando, R. E., Graff‐Radford, J., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00141-8 · Cited by 7 · see citing works

SARS-CoV-2, COVID-19 and the aging immune system

Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works

Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases

Fekete, M., Szarvas, Z., Fazekas-Pongor, V., Feher, A., Csipo, T., Forrai, J., Dosa, N., Peterfi, A., Lehoczki, A., Tarantini, S., et al. (2022) · Nutrients · doi:10.3390/nu15010047 · Cited by 137 · see citing works

NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

Alegre, G. F. S., & Pastore, G. M. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00475-y · Cited by 101 · see citing works

Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain

Kiss, T., Nyúl-Tóth, Á., DelFavero, J., Balasubramanian, P., Tarantini, S., Faakye, J., Gulej, R., Ahire, C., Ungvari, A., Yabluchanskiy, A., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00521-7 · Cited by 66 · see citing works

Metabolic reprogramming: a bridge between aging and tumorigenesis

Drapela, S., Ilter, D., & Gomes, A. P. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13261 · Cited by 41 · see citing works

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Ratajczak, J., Joffraud, M., Trammell, S. A. J., Ras, R., Canela, N., Boutant, M., Kulkarni, S. S., Rodrigues, M., Redpath, P., Migaud, M. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13103 · Cited by 378 · see citing works

Faculty Opinions recommendation of NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.

Imai, S. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726835440.793584719

Reduced nicotinamide mononucleotide is a new and potent NAD + precursor in mammalian cells and mice

Perez, R. Z., Tammaro, A., Schomakers, B. V., Scantlebery, A. M. L., Denis, S. W., Elfrink, H. L., Giroud‐Gerbetant, J., Cantó, C., López‐Leonardo, C., McIntyre, R. L., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202001826r · Cited by 75 · see citing works

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

Fletcher, R. S., Ratajczak, J., Doig, C. L., Oakey, L. A., Callingham, R., Xavier, G. D. S., Garten, A., Elhassan, Y., Redpath, P., Migaud, M. E., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.05.011 · Cited by 121 · see citing works

Quantitative dynamics of intracellular NMN by genetically encoded biosensorPreprint

Chen, L., Wang, P., Huang, G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.23.563573 · Cited by 2 · see citing works