Birch, Jodie

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications

Telomeres, Telomerase, and SenescenceInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 1,613

Senescence and the SASP: many therapeutic avenues

Birch, J., & Gil, J. (2020) · Genes & Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,177

Mitochondria are required for pro-ageing features of the senescent phenotype

Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 796

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., et al. (2019) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 532

Cardiac glycosides are broad-spectrum senolytics

Guerrero, A., Herranz, N., Sun, B., Wagner, V., Gallage, S., Guiho, R., Wolter, K., Pombo, J., Irvine, E. E., Innes, A. J., et al. (2019) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 359

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Victorelli, S., Lagnado, A., Halim, J., Moore, W., Talbot, D., Barrett, K., Chapman, J., Birch, J., Ogrodnik, M., Meves, A., et al. (2019) · The EMBO Journal

Telomeres, Telomerase, and SenescenceSkin Protection and Aging

Cited by 258

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Haston, S., Gonzalez-Gualda, E., Morsli, S., Ge, J., Reen, V., Calderwood, A., Moutsopoulos, I., Panousopoulos, L., Deletic, P., Carreno, G., et al. (2023) · Cancer Cell

Telomeres, Telomerase, and SenescenceImmune cells in cancer

Cited by 251

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., et al. (2021) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 211

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

Birch, J., Anderson, R. K., Correia-Melo, C., Jurk, D., Hewitt, G., Marques, F. M., Green, N. J., Moisey, E., Birrell, M. A., Belvisi, M. G., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Telomeres, Telomerase, and SenescenceChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 174

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Hari, P., Millar, F. R., Tarrats, N., Birch, J., Quintanilla, A., Rink, C. J., Fernández-Duran, I., Muir, M., Finch, A. J., Brunton, V. G., et al. (2019) · Science Advances

Telomeres, Telomerase, and SenescenceImmune Response and Inflammation

Cited by 154

Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

Birch, J., & Passos, J. F. (2017) · BioEssays

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 89

Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice

Correia‐Melo, C., Birch, J., Fielder, E., Rahmatika, D., Taylor, J., Chapman, J., Lagnado, A., Carroll, B. M., Miwa, S., Richardson, G., et al. (2019) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 77

Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis

Birch, J., Victorelli, S., Rahmatika, D., Anderson, R. K., Jiwa, K., Moisey, E., Ward, C., Fisher, A. J., Soyza, A. D., & Passos, J. F. (2016) · American Journal of Respiratory and Critical Care Medicine

Telomeres, Telomerase, and SenescenceCystic Fibrosis Research Advances

Cited by 44