Koves, Timothy R.

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 1,990

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency

Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 464

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine

Lipid metabolism and biosynthesisDiet, Metabolism, and Disease

Cited by 450

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility

Muoio, D. M., Noland, R. C., Kovalik, J.-P., Seiler, S. E., Davies, M. N., DeBalsi, K. L., Ilkayeva, O. R., Stevens, R. D., Kheterpal, I., Zhang, J., et al. (2012) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 372

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control

Noland, R. C., Koves, T. R., Seiler, S. E., Lum, H., Lust, R. M., Ilkayeva, O., Stevens, R. D., Hegardt, F. G., & Muoio, D. M. (2009) · Journal of Biological Chemistry

Metabolism and Genetic DisordersAdipose Tissue and Metabolism

Cited by 317

Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase

Ussher, J. R., Koves, T. R., Jaswal, J. S., Zhang, L., Ilkayeva, O., Dyck, J. R. B., Muoio, D. M., & Lopaschuk, G. D. (2009) · Diabetes

Cardiovascular Function and Risk FactorsCancer, Lipids, and Metabolism

Cited by 135

Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1α: implications for metabolic disease

Muoio, D. M., & Koves, T. R. (2007) · Applied Physiology, Nutrition, and Metabolism

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 129

Metabolic profiling of PPARα −/− mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

Makowski, L., Noland, R. C., Koves, T. R., Xing, W., Ilkayeva, O. R., Muehlbauer, M. J., Stevens, R. D., & Muoio, D. M. (2009) · The FASEB Journal

Peroxisome Proliferator-Activated ReceptorsMetabolism and Genetic Disorders

Cited by 113

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

Thyfault, J. P., Cree, M. G., Zheng, D., Zwetsloot, J. J., Tapscott, E. B., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Muoio, D. M., & Dohm, G. L. (2007) · American Journal of Physiology-Cell Physiology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 87

A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals

Boyle, K. E., Canham, J. P., Consitt, L. A., Zheng, D., Koves, T. R., Gavin, T. P., Holbert, D., Neufer, P. D., Ilkayeva, O., Muoio, D. M., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 79

Sex Differences in Substrate Metabolism and Energy Homeostasis

Cortright, R. N., & Koves, T. R. (2000) · Canadian Journal of Applied Physiology

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 75

Metabolic profiling of muscle contraction in lean compared with obese rodents

Thyfault, J. P., Cree, M. G., Tapscott, E. B., Bell, J. A., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Dohm, G. L., & Muoio, D. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 21