Shen, John Paul

Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions

Shen, J. P., Zhao, D., Sasik, R., Luebeck, J., Birmingham, A., Bojorquez-Gomez, A., Licon, K., Klepper, K., Pekin, D., Beckett, A. N., et al. (2017) · Nature Methods

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 359

Patient-derived micro-organospheres enable clinical precision oncology

Ding, S., Hsu, C., Wang, Z., Natesh, N. R., Millen, R., Negrete, M., Giroux, N., Rivera, G. O., Dohlman, A., Bose, S., et al. (2022) · Cell Stem Cell

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 228

Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung Cancer

Murtuza, A., Bulbul, A., Shen, J. P., Keshavarzian, P., Woodward, B. D., Lopez-Diaz, F. J., Lippman, S. M., & Husain, H. (2019) · Cancer Research

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 226

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Bradner, J. E., Mak, R., Tanguturi, S. K., Mazitschek, R., Haggarty, S. J., Ross, K., Chang, C. Y., Bosco, J., West, N., Morse, E., et al. (2010) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersHistone Deacetylase Inhibitors Research

Cited by 211

Survival improvement for patients with metastatic colorectal cancer over twenty years

Zeineddine, F. A., Zeineddine, M. A., Yousef, A., Gu, Y., Chowdhury, S., Dasari, A., Huey, R. W., Johnson, B., Kee, B., Lee, M. S., et al. (2023) · npj Precision Oncology

Colorectal Cancer Treatments and StudiesColorectal Cancer Surgical Treatments

Cited by 192

Few-shot learning creates predictive models of drug response that translate from high-throughput screens to individual patients

Ma, J., Fong, S. H., Luo, Y., Bakkenist, C. J., Shen, J. P., Mourragui, S., Wessels, L. F. A., Hafner, M., Sharan, R., Peng, J., et al. (2021) · Nature Cancer

Computational Drug Discovery MethodsDomain Adaptation and Few-Shot Learning

Cited by 180

Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression

Hsu, W.-H., LaBella, K. A., Lin, Y., Xu, P., Lee, R., Hsieh, C.-E., Yang, L., Zhou, A., Blecher, J. M., Wu, C.-J., et al. (2023) · Cancer Discovery

Cancer Cells and MetastasisAngiogenesis and VEGF in Cancer

Cited by 125

Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma

Yousef, A., Yousef, M., Chowdhury, S., Abdilleh, K., Knafl, M., Edelkamp, P., Alfaro-Munoz, K., Chacko, R., Peterson, J., Smaglo, B. G., et al. (2024) · npj Precision Oncology

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 93

Comprehensive Clinical and Molecular Characterization of KRASG12C-Mutant Colorectal Cancer

Henry, J. T., Coker, O., Chowdhury, S., Shen, J. P., Morris, V. K., Dasari, A., Raghav, K., Nusrat, M., Kee, B., Parseghian, C., et al. (2021) · JCO Precision Oncology

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 66

Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation

Mayeur, C., Kolodziej, S. A., Wang, A., Xu, X., Lee, A., Yu, P. B., Shen, J., Bloch, K. D., & Bloch, D. B. (2015) · Haematologica

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 38

Bintrafusp Alfa, an Anti-PD-L1:TGFβ Trap Fusion Protein, in Patients with ctDNA-positive, Liver-limited Metastatic Colorectal Cancer

Morris, V. K., Overman, M. J., Lam, M., Parseghian, C. M., Johnson, B., Dasari, A., Raghav, K., Kee, B. K., Huey, R., Wolff, R. A., et al. (2022) · Cancer Research Communications

Colorectal Cancer Treatments and StudiesCancer Immunotherapy and Biomarkers

Cited by 38

Aspirin use and PI3K mutations in metastatic colorectal cancer (mCRC).

Payapwattanawong, S., Osterlund, E., Vetere, G., Bent, A. H., Dasari, A., Kee, B. K., Parseghian, C., Willis, J., Shen, J. P. Y. C., Raghav, K. P. S., et al. (2026) · Journal of Clinical Oncology

Colorectal Cancer Treatments and StudiesInflammatory mediators and NSAID effects

Cited by 1