Boutros, Paul C.

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Aaltonen, L. A., Abascal, F., Abeshouse, A., Aburatani, H., Adams, D. J., Agrawal, N., Ahn, K. S., Ahn, S.-M., Aikata, H., et al. (2020) · Nature

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

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Molecular landmarks of tumor hypoxia across cancer types

Bhandari, V., Hoey, C., Liu, L. Y., Lalonde, E., Ray, J., Livingstone, J., Lesurf, R., Shiah, Y.-J., Vujcic, T., Huang, X., et al. (2019) · Nature Genetics

Cancer, Hypoxia, and MetabolismCancer Genomics and Diagnostics

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Widespread and Functional RNA Circularization in Localized Prostate Cancer

Chen, S., Huang, V., Xu, X., Livingstone, J., Soares, F., Jeon, J., Zeng, Y., Hua, J. T., Petricca, J., Guo, H., et al. (2019) · Cell

Circular RNAs in diseasesRNA Research and Splicing

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Best practices for benchmarking germline small-variant calls in human genomes

the Global Alliance for Genomics and Health Benchmarking Team, Krusche, P., Trigg, L., Boutros, P. C., Mason, C. E., De La Vega, F. M., Moore, B. L., Gonzalez-Porta, M., Eberle, M. A., Tezak, Z., et al. (2019) · Nature Biotechnology

Genomics and Phylogenetic StudiesGenomics and Rare Diseases

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A robust benchmark for detection of germline large deletions and insertions

Zook, J. M., Hansen, N. F., Olson, N. D., Chapman, L., Mullikin, J. C., Xiao, C., Sherry, S., Koren, S., Phillippy, A. M., Boutros, P. C., et al. (2020) · Nature Biotechnology

Genomic variations and chromosomal abnormalitiesGenomics and Phylogenetic Studies

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Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study

Lalonde, E., Ishkanian, A. S., Sykes, J., Fraser, M., Ross-Adams, H., Erho, N., Dunning, M. J., Halim, S., Lamb, A. D., Moon, N. C., et al. (2014) · The Lancet Oncology

Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and Treatment

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Three-gene prognostic classifier for early-stage non small-cell lung cancer

Lau, S. K., Boutros, P. C., Pintilie, M., Blackhall, F. H., Zhu, C.-Q., Strumpf, D., Johnston, M. R., Darling, G., Keshavjee, S., Waddell, T. K., et al. (2007) · Journal of Clinical Oncology

Lung Cancer Research StudiesBreast Cancer Treatment Studies

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Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer

Guo, H., Ahmed, M., Zhang, F., Yao, C. Q., Li, S., Liang, Y., Hua, J., Soares, F., Sun, Y., Langstein, J., et al. (2016) · Nature Genetics

Cancer-related molecular mechanisms researchProstate Cancer Treatment and Research

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Drug screening at single-organoid resolution via bioprinting and interferometry

Tebon, P. J., Wang, B., Markowitz, A. L., Davarifar, A., Krawczuk, P., Murray, G., Nguyen, H. T. L., Tavanaie, N., Nguyen, T. L., Boutros, P. C., et al. (2021) · Nature Communications

3D Printing in Biomedical ResearchDigital Holography and Microscopy

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Two phases of disulfide bond formation have differing requirements for oxygen

Koritzinsky, M., Levitin, F., van den Beucken, T., Rumantir, R. A., Harding, N. J., Chu, K. C., Boutros, P. C., Braakman, I., & Wouters, B. G. (2013) · Journal of Cell Biology

Endoplasmic Reticulum Stress and DiseaseRedox biology and oxidative stress

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Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case of the aryl hydrocarbon receptor

OKEY, A., FRANC, M., MOFFAT, I., TIJET, N., BOUTROS, P., KORKALAINEN, M., TUOMISTO, J., & POHJANVIRTA, R. (2005) · Toxicology and Applied Pharmacology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

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Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus

Li, T., Prokopec, S. D., Morrison, S., Lou, W., Reich, H., Gladman, D., Urowitz, M., Scholey, J., Fortin, P. R., Boutros, P. C., et al. (2015) · Rheumatology

Systemic Lupus Erythematosus ResearchSystemic Sclerosis and Related Diseases

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Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes

Khoo, A., Govindarajan, M., Qiu, Z., Liu, L. Y., Ignatchenko, V., Waas, M., Macklin, A., Keszei, A., Neu, S., Main, B. P., et al. (2024) · Nature Communications

Extracellular vesicles in diseaseAdvanced Proteomics Techniques and Applications

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Prostate Cancer Reshapes the Secreted and Extracellular Vesicle Urinary Proteomes

Khoo, A., Govindarajan, M., Qiu, Z., Liu, L. Y., Ignatchenko, V., Waas, M., Macklin, A., Keszei, A., Main, B. P., Yang, L., et al. (2023) · Nature Communications

Extracellular vesicles in diseaseAdvanced Proteomics Techniques and Applications

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Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer

Ghasemi, F., Black, M., Vizeacoumar, F., Pinto, N., Ruicci, K. M., Le, C. C. S. H., Lowerison, M. R., Leong, H. S., Yoo, J., Fung, K., et al. (2017) · Oncotarget

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