Chen, Baoyu

The WAVE regulatory complex links diverse receptors to the actin cytoskeleton

Chen, B., Brinkmann, K., Chen, Z., Pak, C. W., Liao, Y., Shi, S., Henry, L., Grishin, N. V., Bogdan, S., & Rosen, M. K. (2014) · Cell

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 323

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

Chen, B., Chou, H.-T., Brautigam, C. A., Xing, W., Yang, S., Henry, L., Doolittle, L. K., Walz, T., & Rosen, M. K. (2017) · eLife

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 173

Local F-actin Network Links Synapse Formation and Axon Branching

Chia, P. H., Chen, B., Li, P., Rosen, M. K., & Shen, K. (2014) · Cell

Neuroscience and Neuropharmacology ResearchAxon Guidance and Neuronal Signaling

Cited by 145

WAVE regulatory complex

Rottner, K., Stradal, T. E. B., & Chen, B. (2021) · Current Biology

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 116

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease

Cook, S. A., Comrie, W. A., Poli, M. C., Similuk, M., Oler, A. J., Faruqi, A. J., Kuhns, D. B., Yang, S., Vargas-Hernández, A., Carisey, A. F., et al. (2020) · Science

Immunodeficiency and Autoimmune DisordersPI3K/AKT/mTOR signaling in cancer

Cited by 102

Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase

Ding, B., Yang, S., Schaks, M., Liu, Y., Brown, A. J., Rottner, K., Chowdhury, S., & Chen, B. (2022) · Nature Communications

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 82

WASP family proteins: Molecular mechanisms and implications in human disease

Kramer, D. A., Piper, H. K., & Chen, B. (2022) · European Journal of Cell Biology

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 57

Structural organization of the retriever–CCC endosomal recycling complex

Boesch, D. J., Singla, A., Han, Y., Kramer, D. A., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M. J., et al. (2024) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 52

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

Boesch, D., Singla, A., Han, Y., Kramer, D., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M., et al. (2023) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 51

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

Boesch, D. J., Singla, A., Han, Y., Kramer, D. A., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M. J., et al. (2023) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 51

Arf GTPase activates the WAVE regulatory complex through a distinct binding site

Yang, S., Tang, Y., Liu, Y., Brown, A. J., Schaks, M., Ding, B., Kramer, D. A., Mietkowska, M., Ding, L., Alekhina, O., et al. (2022) · Science Advances

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 24

Structural basis for Retriever-SNX17 assembly and endosomal sorting

Singla, A., Boesch, D. J., Fung, H. Y. J., Ngoka, C., Enriquez, A. S., Song, R., Kramer, D. A., Han, Y., Banarer, E., Lemoff, A., et al. (2024) · Nature Communications

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 23

The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

Kramer, D. A., Narvaez-Ortiz, H. Y., Patel, U., Shi, R., Shen, K., Nolen, B. J., Roche, J., & Chen, B. (2022) · eLife

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 7

The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

Kramer, D. A., Narvaez-Ortiz, H. Y., Patel, U., Shi, R., Shen, K., Nolen, B. J., Roche, J., & Chen, B. (2023) · eLife

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 7

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

Comrie, W. A., Poli, M. C., Cook, S. A., Similuk, M., Oler, A. J., Faruqi, A. J., Kuhns, D. B., Yang, S., Carisey, A. F., Fournier, B., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

Cited by 3

CCDC22 mutations that impair COMMD binding cause attenuated 3C/Ritscher-Schinzel syndrome

Singla, A., Rogers, C., Touma, M.-J., El-Najjar, Y., Colley, A., Boesch, D. J., Billadeau, D. D., Gecz, J., Chen, B., & Burstein, E. (2025) · BMC Medical Genomics

Cellular transport and secretionGenomics and Rare Diseases

Cited by 1