Stout, Michael B.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,584

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., et al. (2016) · Aging Cell

Telomeres, Telomerase, and SenescenceCell death mechanisms and regulation

Cited by 1,148

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 915

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceAdipokines, Inflammation, and Metabolic Diseases

Cited by 658

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife

Telomeres, Telomerase, and SenescenceAdipose Tissue and Metabolism

Cited by 604

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

Stout, M. B., Justice, J. N., Nicklas, B. J., & Kirkland, J. L. (2017) · Physiology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 272

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., et al. (2016) · Diabetes

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 267

Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity

Winnick, J. J., Sherman, W. M., Habash, D. L., Stout, M. B., Failla, M. L., Belury, M. A., & Schuster, D. P. (2008) · The Journal of Clinical Endocrinology & Metabolism

Diabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and Health

Cited by 153

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J.-P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., et al. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Adipose Tissue and MetabolismHormonal and reproductive studies

Cited by 119

Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion

Ansere, V. A., Ali-Mondal, S., Sathiaseelan, R., Garcia, D. N., Isola, J. V. V., Henseb, J. D., Saccon, T. D., Ocañas, S. R., Tooley, K. B., Stout, M. B., et al. (2021) · Mechanisms of Ageing and Development

Reproductive Biology and FertilityTelomeres, Telomerase, and Senescence

Cited by 101

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

Huffman, D. M., Justice, J. N., Stout, M. B., Kirkland, J. L., Barzilai, N., & Austad, S. N. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 52

Inflammation and the depot-specific secretome of human preadipocytes

Zhu, Y., Tchkonia, T., Stout, M. B., Giorgadze, N., Wang, L., Li, P. W., Heppelmann, C. J., Bouloumié, A., Jensen, M. D., Bergen, H. R., et al. (2015) · Obesity

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 42