Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

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The Hallmarks of Aging

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Frailty in elderly people

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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Inflammation and insulin resistance

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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Gait speed and survival in older adults.

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C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

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Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

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Cellular senescence in cancer and aging.

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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The cellular and signaling networks linking the immune system and metabolism in disease

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Insulin and insulin resistance:

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Metformin improves healthspan and lifespan in mice

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Muscle Mass, Muscle Strength, and Muscle Fat Infiltration as Predictors of Incident Mobility Limitations in Well-Functioning Older Persons

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IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

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Diabetes in Older Adults

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Promoting Health and Longevity through Diet: From Model Organisms to Humans

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CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.Preprint

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

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Prevalence and 10‐Year Outcomes of Frailty in Older Adults in Relation to Deficit Accumulation

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Cardiovascular Health Study Collaborative Research Group : Frailty in older adults : evidence for a phenotype

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Fat tissue, aging, and cellular senescence

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Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study

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Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes

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Age and gender comparisons of muscle strength in 654 women and men aged 20–93 yr

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Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>

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Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly

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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

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A crucial role for adipose tissue p53 in the regulation of insulin resistance

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Serum IL‐6 Level and the Development of Disability in Older Persons

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Age-related changes in total and regional fat distribution

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Obesity accelerates epigenetic aging of human liver

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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

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Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

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Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

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The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

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Targeting senescent cells enhances adipogenesis and metabolic function in old age

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Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

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The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly

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Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment

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Preadipocyte Conversion to Macrophage

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Prospective Study of C-Reactive Protein in Relation to the Development of Diabetes and Metabolic Syndrome in the Mexico City Diabetes Study

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Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice

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Insulin resistance associated to obesity: the link TNF-alpha

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Pathogenesis of Type 2 Diabetes Mellitus

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Innate immunity and inflammation in ageing: a key for understanding age-related diseases

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Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

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Sarcopenia, obesity, and inflammation—results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study

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Insulin resistance of muscle protein metabolism in aging

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Impaired Preadipocyte Differentiation in Human Abdominal Obesity

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Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

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Regional Anatomic and Age Effects on Cell Function of Human Adipose-Derived Stem Cells

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Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns

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Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

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Depletion of fat-resident Treg cells prevents age-associated insulin resistance

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Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

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Inflammation and impaired adipogenesis in hypertrophic obesity in man

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Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue

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