Markusic, David M.

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver

Martino, A. T., Suzuki, M., Markusic, D. M., Zolotukhin, I., Ryals, R. C., Moghimi, B., Ertl, H. C. J., Muruve, D. A., Lee, B., & Herzog, R. W. (2011) · Blood

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 246

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells

Martino, A. T., Basner-Tschakarjan, E., Markusic, D. M., Finn, J. D., Hinderer, C., Zhou, S., Ostrov, D. A., Srivastava, A., Ertl, H. C. J., Terhorst, C., et al. (2013) · Blood

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 162

High-efficiency transduction and correction of murine hemophilia b using AAV2 vectors devoid of multiple surface-exposed tyrosines

Markusic, D. M., Herzog, R. W., Aslanidi, G. V., Hoffman, B. E., Li, B., Li, M., Jayandharan, G. R., Ling, C., Zolotukhin, I., Ma, W., et al. (2010) · Molecular Therapy

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 131

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

Markusic, D. M., Hoffman, B. E., Perrin, G. Q., Nayak, S., Wang, X., LoDuca, P. A., High, K. A., & Herzog, R. W. (2013) · EMBO Molecular Medicine

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 116

Immune Response Mechanisms against AAV Vectors in Animal Models

Martino, A. T., & Markusic, D. M. (2020) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 97

Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer

Rogers, G. L., Suzuki, M., Zolotukhin, I., Markusic, D. M., Morel, L. M., Lee, B., Ertl, H. C. J., & Herzog, R. W. (2015) · Journal of Innate Immunity

Virus-based gene therapy researchImmune Response and Inflammation

Cited by 85

Liver induced transgene tolerance with AAV vectors

Keeler, G. D., Markusic, D. M., & Hoffman, B. E. (2019) · Cellular Immunology

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 81

Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells

Shirley, J. L., Keeler, G. D., Sherman, A., Zolotukhin, I., Markusic, D. M., Hoffman, B. E., Morel, L. M., Wallet, M. A., Terhorst, C., & Herzog, R. W. (2020) · Molecular Therapy

Immunotherapy and Immune ResponsesVirus-based gene therapy research

Cited by 79

Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter

Markusic, D. (2005) · Nucleic Acids Research

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 78

Development of gene transfer for induction of antigen-specific tolerance

Sack, B. K., Herzog, R. W., Terhorst, C., & Markusic, D. M. (2014) · Molecular Therapy - Methods & Clinical Development

Immunotherapy and Immune ResponsesVirus-based gene therapy research

Cited by 70

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg

Biswas, M., Sarkar, D., Kumar, S. R. P., Nayak, S., Rogers, G. L., Markusic, D. M., Liao, G., Terhorst, C., & Herzog, R. W. (2015) · Blood

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 70

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

Zolotukhin, I., Markusic, D. M., Palaschak, B., Hoffman, B. E., Srikanthan, M. A., & Herzog, R. W. (2016) · Molecular Therapy - Methods & Clinical Development

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 65

Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia

Sarkar, D., Biswas, M., Liao, G., Seay, H. R., Perrin, G. Q., Markusic, D. M., Hoffman, B. E., Brusko, T. M., Terhorst, C., & Herzog, R. W. (2014) · Molecular Therapy - Methods & Clinical Development

Hemophilia Treatment and ResearchT-cell and B-cell Immunology

Cited by 62

Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

Martino, A. T., Nayak, S., Hoffman, B. E., Cooper, M., Liao, G., Markusic, D. M., Byrne, B. J., Terhorst, C., & Herzog, R. W. (2009) · PLoS ONE

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 54

Complement System Response to Adeno-Associated Virus Vector Gene Therapy

Kropf, E., Markusic, D. M., Majowicz, A., Mingozzi, F., & Kuranda, K. (2024) · Human Gene Therapy

Virus-based gene therapy researchComplement system in diseases

Cited by 39

B cell depletion eliminates FVIII memory b cells and enhances AAV8-coF8 immune tolerance induction when combined with rapamycin

Biswas, M., Palaschak, B., Kumar, S. R. P., Rana, J., & Markusic, D. M. (2020) · Frontiers in Immunology

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 28

B cell focused transient immune suppression protocol for efficient AAV readministration to the liver

Rana, J., Herzog, R. W., Muñoz-Melero, M., Yamada, K., Kumar, S. R. P., Lam, A. K., Markusic, D. M., Duan, D., Terhorst, C., Byrne, B. J., et al. (2024) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 26

Separating Lentiviral Vector Injection and Induction of Gene Expression in Time, Does Not Prevent an Immune Response to rtTA in Rats

Markusic, D. M., de Waart, D. R., & Seppen, J. (2010) · PLoS ONE

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 22

An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells

Palaschak, B., Marsic, D., Herzog, R. W., Zolotukhin, S., & Markusic, D. M. (2017) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 19

Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Vectors for Modulating Humoral Immune Response

Kwon, H.-J., Qing, K., Ponnazhagan, S., Wang, X.-S., Markusic, D. M., Gupte, S., Boye, S. E., & Srivastava, A. (2020) · Human Gene Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 6

Intravitreal AAV vector delivery induces integrin-dependent ocular inflammation, complement activation, and antiviral and DNA damage responses

Costa-Verdera, H., Jamwal, D., Fabyanic, E., Hippen, A., Salvatore, M., Du, A., Majowicz, A., Markusic, D., Chatterton, J. E., Haurigot, V., et al. (2026) · Frontiers in Immunology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 2