Vitkup, Dennis

Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses

Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 701

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras -driven cancers

Mayers, J. R., Torrence, M. E., Danai, L. V., Papagiannakopoulos, T., Davidson, S. M., Bauer, M. R., Lau, A. N., Ji, B. W., Dixit, P. D., Hosios, A. M., et al. (2016) · Science

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 582

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

Hu, J., Locasale, J. W., Bielas, J. H., O'Sullivan, J., Sheahan, K., Cantley, L. C., Heiden, M. G. V., & Vitkup, D. (2013) · Nature Biotechnology

Cancer, Hypoxia, and MetabolismBioinformatics and Genomic Networks

Cited by 407

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

Gilman, S. R., Chang, J., Xu, B., Bawa, T. S., Gogos, J. A., Karayiorgou, M., & Vitkup, D. (2012) · Nature Neuroscience

Schizophrenia research and treatmentBioinformatics and Genomic Networks

Cited by 200

Genotype to phenotype relationships in autism spectrum disorders

Chang, J., Gilman, S. R., Chiang, A. H., Sanders, S. J., & Vitkup, D. (2015) · Nature Neuroscience

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 197

Influence of metabolic network structure and function on enzyme evolution

Vitkup, D., Kharchenko, P., & Wagner, A. (2006) · Genome biology

Bioinformatics and Genomic NetworksMicrobial Metabolic Engineering and Bioproduction

Cited by 175

Properties of cell death models calibrated and compared using Bayesian approaches

Eydgahi, H., Chen, W. W., Muhlich, J. L., Vitkup, D., Tsitsiklis, J. N., & Sorger, P. K. (2013) · Molecular Systems Biology

Gene Regulatory Network AnalysisCell death mechanisms and regulation

Cited by 84

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Li, Z., Ji, B. W., Dixit, P. D., Tchourine, K., Lien, E. C., Hosios, A. M., Abbott, K. L., Rutter, J. C., Westermark, A. M., Gorodetsky, E. F., et al. (2022) · Nature Metabolism

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 81