Clark, Simon J.

The complement system in age-related macular degeneration

Armento, A., Ueffing, M., & Clark, S. J. (2021) · Cellular and Molecular Life Sciences

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 258

His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form

Clark, S. J., Higman, V. A., Mulloy, B., Perkins, S. J., Lea, S. M., Sim, R. B., & Day, A. J. (2006) · Journal of Biological Chemistry

Complement system in diseasesRetinal Diseases and Treatments

Cited by 185

Structural basis for complement factor H linked age-related macular degeneration

Prosser, B. E., Johnson, S., Roversi, P., Herbert, A. P., Blaum, B. S., Tyrrell, J., Jowitt, T. A., Clark, S. J., Tarelli, E., Uhrín, D., et al. (2007) · The Journal of Experimental Medicine

Complement system in diseasesRetinal Diseases and Treatments

Cited by 184

Identification of factor H-like protein 1 as the predominant complement regulator in Bruch’s membrane: Implications for age-related macular degeneration

Clark, S. J., Schmidt, C. Q., White, A. M., Hakobyan, S., Morgan, B. P., & Bishop, P. N. (2014) · The Journal of Immunology

Complement system in diseasesRetinal Diseases and Treatments

Cited by 122

Complementing the sugar code: Role of GAGs and sialic acid in complement regulation

Langford-Smith, A., Day, A. J., Bishop, P. N., & Clark, S. J. (2015) · Frontiers in Immunology

Complement system in diseasesGlycosylation and Glycoproteins Research

Cited by 80

Bruch’s Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration

Clark, S. J., McHarg, S., Tilakaratna, V., Brace, N., & Bishop, P. N. (2017) · Frontiers in Immunology

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 71

Age-dependent changes in heparan sulfate in human Bruch’s membrane: Implications for age-related macular degeneration

Keenan, T. D. L., Pickford, C. E., Holley, R. J., Clark, S. J., Lin, W., Dowsey, A. W., Merry, C. L., Day, A. J., & Bishop, P. N. (2014) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsProteoglycans and glycosaminoglycans research

Cited by 65

The proteoglycan glycomatrix: A sugar microenvironment essential for complement regulation

Clark, S. J., Bishop, P. N., & Day, A. J. (2013) · Frontiers in Immunology

Proteoglycans and glycosaminoglycans researchComplement system in diseases

Cited by 39

Therapeutic targeting of the complement system in ocular disease

Rathi, S., Hasan, R., Ueffing, M., & Clark, S. J. (2023) · Drug Discovery Today

Complement system in diseasesRetinal Diseases and Treatments

Cited by 24