Zhang, Donna D.

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell

Ferroptosis and cancer prognosisIron Metabolism and Disorders

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 2,897

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Dodson, M., Castro-Portuguez, R., & Zhang, D. D. (2019) · Redox Biology

Genomics, phytochemicals, and oxidative stressFerroptosis and cancer prognosis

Cited by 2,435

NRF2 and the Hallmarks of Cancer

Rojo de la Vega, M., Chapman, E., & Zhang, D. D. (2018) · Cancer Cell

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,672

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

Zhang, D. D., & Hannink, M. (2003) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,480

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

Ren, D., Villeneuve, N. F., Jiang, T., Wu, T., Lau, A., Toppin, H. A., & Zhang, D. D. (2011) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressBioactive Compounds and Antitumor Agents

Cited by 673

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 638

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

Zheng, H., Whitman, S. A., Wu, W., Wondrak, G. T., Wong, P. K., Fang, D., & Zhang, D. D. (2011) · Diabetes

Genomics, phytochemicals, and oxidative stressChronic Kidney Disease and Diabetes

Cited by 507

USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development

Lin, Z., Yang, H., Kong, Q., Li, J., Lee, S.-M., Gao, B., Dong, H., Wei, J., Song, J., Zhang, D. D., et al. (2012) · Molecular Cell

Ubiquitin and proteasome pathwaysSirtuins and Resveratrol in Medicine

Cited by 315

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

Tao, S., Wang, S., Moghaddam, S. J., Ooi, A., Chapman, E., Wong, P. K., & Zhang, D. D. (2014) · Cancer Research

Genomics, phytochemicals, and oxidative stressLung Cancer Treatments and Mutations

Cited by 291

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

Jiang, T., Chen, N., Zhao, F., Wang, X.-J., Kong, B., Zheng, W., & Zhang, D. D. (2010) · Cancer Research

Genomics, phytochemicals, and oxidative stressEndometrial and Cervical Cancer Treatments

Cited by 286

Thirty years of NRF2: advances and therapeutic challenges.

Zhang, D. D. (2025) · Nature Reviews Drug Discovery

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 282

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

Tao, S., Justiniano, R., Zhang, D. D., & Wondrak, G. T. (2013) · Redox Biology

Skin Protection and AgingGenomics, phytochemicals, and oxidative stress

Cited by 103

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2

Tao, S., Park, S. L., de la Vega, M. R., Zhang, D. D., & Wondrak, G. T. (2015) · Free Radical Biology and Medicine

Skin Protection and AgingGenomics, phytochemicals, and oxidative stress

Cited by 96

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

Long, M., Tao, S., Rojo de la Vega, M., Jiang, T., Wen, Q., Park, S. L., Zhang, D. D., & Wondrak, G. T. (2015) · Cancer Prevention Research

Genomics, phytochemicals, and oxidative stressPhytochemicals and Antioxidant Activities

Cited by 86

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Tao, S., Rojo de la Vega, M., Quijada, H., Wondrak, G. T., Wang, T., Garcia, J. G. N., & Zhang, D. D. (2016) · Scientific Reports

Genomics, phytochemicals, and oxidative stressRespiratory Support and Mechanisms

Cited by 68

Topical bixin confers NRF2-dependent protection against photodamage and hair graying in mouse skin

Rojo de la Vega, M., Zhang, D. D., & Wondrak, G. T. (2018) · Frontiers in Pharmacology

Skin Protection and AgingGenomics, phytochemicals, and oxidative stress

Cited by 55

Involvement of eNAMPT / TLR4 inflammatory signaling in progression of non‐alcoholic fatty liver disease, steatohepatitis, and fibrosis

Sun, B. L., Sun, X., Kempf, C. L., Song, J. H., Casanova, N. G., Camp, S. M., Reyes Hernon, V., Fallon, M., Bime, C., Martin, D. R., et al. (2023) · The FASEB Journal

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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