Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works

Ferroptosis: process and function

Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727 · see citing works

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398 · see citing works

Ferroptosis: Death by Lipid Peroxidation

Yang, W. S., & Stockwell, B. R. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.014 · Cited by 3,088 · see citing works

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029 · see citing works

Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771 · see citing works

The role of iron and reactive oxygen species in cell death

Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381 · see citing works

Autophagy promotes ferroptosis by degradation of ferritin

Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332 · see citing works

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329 · see citing works

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088 · see citing works

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084 · see citing works

Glutaminolysis and transferrin regulate ferroptosis

Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works

Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Sun, X., Ou, Z., Chen, R., Niu, X., Chen, D., Kang, R., & Tang, D. (2016) · Hepatology · doi:10.1002/hep.28251 · Cited by 2,012 · see citing works

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature · doi:10.1038/nature23007 · Cited by 2,011 · see citing works

Ferroptosis is an autophagic cell death process

Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899 · see citing works

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876 · see citing works

Lipid peroxidation in cell death

Gaschler, M. M., & Stockwell, B. R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.086 · Cited by 1,852 · see citing works

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631 · see citing works

Nutrition Needs of Mammalian Cells in Tissue Culture

Eagle, H. (1955) · Science · doi:10.1126/science.122.3168.501 · Cited by 1,619 · see citing works

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470 · see citing works

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Dolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446 · see citing works

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146 · cited 3× · see citing works

Synchronized renal tubular cell death involves ferroptosis

Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126 · see citing works

Identification of ACSL4 as a biomarker and contributor of ferroptosis

Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.124 · Cited by 1,071 · cited 2× · see citing works

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Zilka, O., Shah, R., Li, B., Angeli, J. P. F., Grießer, M., Conrad, M., & Pratt, D. A. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00028 · Cited by 1,052 · see citing works

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., Superti-Furga, G., & Stockwell, B. R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00245 · Cited by 1,043 · see citing works

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

Murphy, T. H., Miyamoto, M., Sastre, A., Schnaar, R. L., & COYLE, J. T. (1989) · Neuron · doi:10.1016/0896-6273(89)90043-3 · Cited by 1,033 · see citing works

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017 · see citing works

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002 · see citing works

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.055 · Cited by 952 · see citing works

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

Ursini, F., Maiorino, M., Valente, M., Ferri, L., & Gregolin, C. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90150-3 · Cited by 884 · see citing works

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

Hambright, W. S., Fonseca, R. S., Chen, L., Na, R., & Ran, Q. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.021 · Cited by 851 · see citing works

Spreading of pathology in neurodegenerative diseases: a focus on human studies

Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

Guo, J., Xu, B.-F., Han, Q., Zhou, H., Xia, Y. F., Gong, C., Dai, X., Li, Z., & Wu, G. (2017) · Cancer Research and Treatment · doi:10.4143/crt.2016.572 · Cited by 787 · see citing works

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Ou, Y., Wang, S.-J., Li, D., Chu, B., & Gu, W. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607152113 · Cited by 775 · see citing works

Intramuscular desferrioxamine in patients with Alzheimer's disease

MCLACHLAN, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92978-b · Cited by 764 · see citing works

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

Kerins, M. J., & Ooi, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7176 · Cited by 741 · see citing works

Metallothionein‐1G facilitates sorafenib resistance through inhibition of ferroptosis

Sun, X., Niu, X., Chen, R., He, W., Chen, D., Kang, R., & Tang, D. (2016) · Hepatology · doi:10.1002/hep.28574 · Cited by 707 · see citing works

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Tuo, Q.-Z., Lei, P., Jackman, K. A., Li, X.-L., Xiong, H., Li, X.-L., Liuyang, Z.-Y., Roisman, L. C., Zhang, S.-T., Ayton, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.171 · Cited by 706 · see citing works

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

Do Van, B., Gouel, F., Jonneaux, A., Timmerman, K., Gelé, P., Pétrault, M., Bastide, M., Laloux, C., Moreau, C., Bordet, R., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.011 · Cited by 689 · see citing works

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

Gong, Y.-N., Guy, C., Olauson, H., Becker, J. U., Yang, M., Fitzgerald, P., Linkermann, A., & Green, D. R. (2017) · Cell · doi:10.1016/j.cell.2017.03.020 · Cited by 689 · see citing works

Inhibition of neuronal ferroptosis protects hemorrhagic brain

Li, Q., Han, X., Lan, X., Gao, Y., Wan, J., Durham, F., Cheng, T., Yang, J., Wang, Z., Jiang, C. Q., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90777 · Cited by 686 · see citing works

HSPB1 as a novel regulator of ferroptotic cancer cell death

Sun, X., Ou, Z., Xie, M., Kang, R., Fan, Y., Niu, X., Wang, H., Cao, L., & Tang, D. (2015) · Oncogene · doi:10.1038/onc.2015.32 · Cited by 666 · see citing works

Characterization of ferroptosis in murine models of hemochromatosis

Wang, H., An, P., Xie, E., Wu, Q., Fang, X., Gao, H., Zhang, Z., Li, Y., Wang, X., Zhang, J., et al. (2017) · Hepatology · doi:10.1002/hep.29117 · Cited by 656 · see citing works

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Berghe, T. V., Vanlangenakker, N., Parthoens, E., Deckers, W., Devos, M., Festjens, N., Guerin, C. J., Brunk, U. T., Declercq, W., & Vandenabeele, P. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.184 · Cited by 639 · see citing works

Regulated necrosis: disease relevance and therapeutic opportunities

Conrad, M., Angeli, J. P. F., Vandenabeele, P., & Stockwell, B. R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.6 · Cited by 630 · see citing works

Mammalian lipoxygenases and their biological relevance

Kühn, H., Banthiya, S., & van Leyen, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 629 · see citing works

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Dysken, M. W., Sano, M., Asthana, S., Vertrees, J. E., Pallaki, M., Llorente, M., Love, S., Schellenberg, G. D., McCarten, J. R., Malphurs, J., et al. (2014) · JAMA · doi:10.1001/jama.2013.282834 · Cited by 628 · see citing works

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

Devos, D., Moreau, C., Devedjian, J. C., Kluza, J., Pétrault, M., Laloux, C., Jonneaux, A., Ryckewaert, G., Garçon, G., Rouaix, N., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5593 · Cited by 622 · see citing works

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Kim, S. E., Zhang, L., Ma, K., Riegman, M., Chen, F., Ingold, I., Conrad, M., Turker, M. Z., Gao, M., Jiang, X., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.164 · Cited by 622 · see citing works

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

Belaidi, A. A., & Bush, A. I. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 580 · see citing works

Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury

Linkermann, A., Bräsen, J. H., Darding, M., Jin, M. K., Sanz, A. B., Heller, J.-O., Zen, F. D., Weinlich, R., Ortíz, A., Walczak, H., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305538110 · Cited by 568 · see citing works

Ferroptosis Inhibition: Mechanisms and Opportunities

Angeli, J. P. F., Shah, R., Pratt, D. A., & Conrad, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.02.005 · Cited by 563 · see citing works

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

Cramer, S. L., Saha, A., Liu, J., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S. E., Rowlinson, S. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4232 · Cited by 541 · see citing works

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540 · see citing works

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

Zille, M., Karuppagounder, S. S., Chen, Y., Gough, P. J., Bertin, J., Finger, J. N., Milner, T. A., Jonas, E. A., & Ratan, R. R. (2017) · Stroke · doi:10.1161/strokeaha.116.015609 · Cited by 530 · see citing works

Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

Eling, N., Reuter, L., Hazin, J., Hamacher-Brady, A., & Brady, N. R. (2015) · Oncoscience · doi:10.18632/oncoscience.160 · Cited by 524 · see citing works

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.034 · Cited by 507 · see citing works

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

Chen, L., Hambright, W. S., Na, R., & Ran, Q. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680090 · Cited by 498 · see citing works

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

Hayano, M., Yang, W., Corn, C. K., Pagano, N. C., & Stockwell, B. R. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.93 · Cited by 462 · see citing works

Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile

der Laan, E. V. D. B.-V., Killian, J. A., & KRUIJFF, B. D. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.06.010 · Cited by 461 · see citing works

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

Newton, K., Dugger, D. L., Maltzman, A., Greve, J. M., Hedehus, M., Martin-McNulty, B., Carano, R. A. D., Cao, T. C., van Bruggen, N., Bernstein, L., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.46 · Cited by 442 · see citing works

Regional Membrane Phospholipid Alterations in Alzheimer's Disease

Prasad, M. R., Lovell, M. A., Yatin, M., Dhillon, H. S., & Markesbery, W. R. (1998) · Neurochemical Research · doi:10.1023/a:1022457605436 · Cited by 440 · see citing works

Redox imbalance in cystine/glutamate transporter-deficient mice

Sato, H., Shiiya, A., Kimata, M., Maebara, K., Tamba, M., Sakakura, Y., Makino, N., Sugiyama, F., Yagami, K.-I., Moriguchi, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506439200 · Cited by 422 · see citing works

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

Williams, T. I., Lynn, B. C., Markesbery, W. R., & Lovell, M. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.004 · Cited by 390 · see citing works

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelPreprint

Jennis, M., Kung, C.-P., Basu, S., Budina-Kolomets, A., Leu, J. I.-J., Khaku, S., Scott, J. P., Cai, K. Q., Campbell, M. R., Porter, D. K., et al. (2016) · Genes & Development · doi:10.1101/gad.275891.115 · Cited by 355 · see citing works

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Gascón, S., Murenu, E., Masserdotti, G., Ortega, F., Russo, G. L., Petřík, D., Deshpande, A., Heinrich, C., Karow, M., Robertson, S. P., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.12.003 · Cited by 354 · see citing works

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

Mandal, P. K., Saharan, S., Tripathi, M., & Murari, G. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.005 · Cited by 339 · see citing works

Ferroptosis and cell death mechanisms in Parkinson's disease

Guiney, S. J., Adlard, P. A., Bush, A. I., Finkelstein, D. I., & Ayton, S. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.01.004 · Cited by 337 · see citing works

Quantification of F2-isoprostanes as a biomarker of oxidative stress

Milne, G. L., Sanchez, S. C., Musiek, E. S., & Morrow, J. D. (2007) · Nature Protocols · doi:10.1038/nprot.2006.375 · Cited by 333 · see citing works

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

Greenamyre, J. T., Penney, J. B., Young, A. B., D’Amato, C. J., Hicks, S. P., & Shoulson, I. (1985) · Science · doi:10.1126/science.2858129 · Cited by 333 · see citing works

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Liu, D. S., Duong, C. P., Haupt, S., Montgomery, K. G., House, C. M., Azar, W. J., Pearson, H. B., Fisher, O. M., Read, M., Guerra, G. R., et al. (2017) · Nature Communications · doi:10.1038/ncomms14844 · Cited by 321 · see citing works

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis

Wang, Y., Chang, S.-Y., Wu, Q., Gou, Y.-J., Jia, L., Cui, Y.-M., Yu, P., Shi, Z.-H., Wu, W.-S., Gao, G., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00308 · Cited by 309 · see citing works

Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity

Shimada, K., Hayano, M., Pagano, N. C., & Stockwell, B. R. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.11.016 · Cited by 300 · see citing works

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

MacLeod, A. K., McMahon, M. J., Plummer, S. M., Higgins, L. G., Penning, T. M., Igarashi, K., & Hayes, J. D. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp176 · Cited by 297 · see citing works

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

Revett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 294 · see citing works

Molecular Basis of Vitamin E Action

Khanna, S., Roy, S., Ryu, H., Bahadduri, P. M., Swaan, P. W., Ratan, R. R., & Sen, C. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307075200 · Cited by 285 · see citing works

Glutathione peroxidase 4: a new player in neurodegeneration?

Cardoso, B. R., Hare, D. J., Bush, A. I., & Roberts, B. R. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.196 · Cited by 281 · see citing works

Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline

Ayton, S., Fazlollahi, A., Bourgeat, P., Raniga, P., Ng, A., Lim, Y. Y., Diouf, I., Farquharson, S., Fripp, J., Ames, D. J., et al. (2017) · Brain · doi:10.1093/brain/awx137 · Cited by 281 · see citing works

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer’s Disease Detected in vivo with Magnetic Resonance Imaging

Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P., & Bartzokis, G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130209 · Cited by 270 · see citing works

Heat stress induces ferroptosis-like cell death in plants

Distéfano, A. M., Martin, M. V., Córdoba, J. P., Bellido, A. M., D’Ippólito, S., Colman, S. L., Soto, D., Roldán, J. A., Bartoli, C. G., Zabaleta, E. J., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201605110 · Cited by 268 · see citing works

Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders

Di Domenico, F., Tramutola, A., & Butterfield, D. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.490 · Cited by 253 · see citing works

Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis

Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.024 · Cited by 252 · see citing works

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

Yoo, S.-E., Chen, L., Na, R., Liu, Y., Rios, C. I., Remmen, H. V., Richardson, A. G., & Ran, Q. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.043 · Cited by 250 · see citing works

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

Xie, Y., Song, X., Sun, X., Huang, J. L., Zhong, M., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.052 · Cited by 246 · see citing works

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

Krainz, T., Gaschler, M. M., Lim, C., Sacher, J. R., Stockwell, B. R., & Wipf, P. (2016) · ACS Central Science · doi:10.1021/acscentsci.6b00199 · Cited by 233 · see citing works

Omega 3 fatty acid for the prevention of cognitive decline and dementia

Sydenham, E., Dangour, A. D., & Lim, W. S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005379.pub3 · Cited by 223 · see citing works

FANCD2 protects against bone marrow injury from ferroptosis

Song, X., Xie, Y., Kang, R., Hou, W., Sun, X., Epperly, M. W., Greenberger, J. S., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.068 · Cited by 200 · see citing works

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

Abrams, R. P. M., Carroll, W. L., & Woerpel, K. A. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.5b00900 · Cited by 189 · see citing works

Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

Greenshields, A. L., Shepherd, T. G., & Hoskin, D. W. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22474 · Cited by 189 · see citing works

Effect of pioglitazone medication on the incidence of dementia

Heneka, M. T., Fink, A., & Doblhammer, G. (2015) · Annals of Neurology · doi:10.1002/ana.24439 · Cited by 185 · see citing works

Chemical tools for detecting Fe ions

Hirayama, T., & Nagasawa, H. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-70 · Cited by 154 · see citing works

A reactivity-based probe of the intracellular labile ferrous iron pool

Spangler, B., Morgan, C. W., Fontaine, S. D., Wal, M. N. V., Chang, C. J., Wells, J. A., & Renslo, A. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2116 · Cited by 151 · see citing works

Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium

Bannai, S., Tsukeda, H., & Okumura, H. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)90623-4 · Cited by 139 · see citing works

Modulatory profiling identifies mechanisms of small molecule-induced cell death

Wolpaw, A. J., Shimada, K., Skouta, R., Welsch, M. E., Akavia, U. D., Pe'er, D., Shaik, F., Bulinski, J. C., & Stockwell, B. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106149108 · Cited by 133 · see citing works

Dopaminergic neurons of system x c – ‐deficient mice are highly protected against 6‐hydroxydopamine‐induced toxicity

Massie, A., Schallier, A., Kim, S. W., Fernando, R. N., Kobayashi, S., Beck, H., Bundel, D. D., Vermoesen, K., Bannai, S., Smolders, I. J., et al. (2010) · The FASEB Journal · doi:10.1096/fj.10-177212 · Cited by 124 · see citing works

Elevated levels of pro‐apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

Cenini, G., Sultana, R., Memo, M., & Butterfield, D. A. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00163.x · Cited by 117 · see citing works

Lipid unsaturation and organelle dynamics

Barelli, H., & Antonny, B. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.03.012 · Cited by 112 · see citing works

The in vivo evidence for regulated necrosis

Tonnus, W., & Linkermann, A. (2017) · Immunological Reviews · doi:10.1111/imr.12551 · Cited by 109 · see citing works

Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice

Wan, C., Li, S., Li, W., et al. (2006) · Plant Cell Reports · doi:10.1007/s00299-006-0234-2 · Cited by 99 · see citing works

Antiferroptotic activity of non-oxidative dopamine

Wang, D., Peng, Y., Xie, Y., Zhou, B., Sun, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.099 · Cited by 88 · see citing works

12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice

Meco, A. D., Li, J.-G., Blass, B. E., Abou-Gharbia, M. A., Lauretti, E., & Praticò, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.023 · Cited by 80 · see citing works

Erratum: Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., et al. (2016) · Nature · doi:10.1038/nature20106 · Cited by 66 · see citing works

Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with1H-MRS and Pittsburgh Compound-B PET

Chiang, G. C.-Y., Mao, X., Kang, G., Chang, E., Pandya, S., Vallabhajosula, S., Isaacson, R., Ravdin, L., Initiative, A. D. N., & Shungu, D. C. (2017) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5143 · Cited by 62 · see citing works

Correction: Corrigendum: Design of a hyperstable 60-subunit protein icosahedron

Hsia, Y., Bale, J. B., Gonen, S., et al. (2016) · Nature · doi:10.1038/nature20108 · Cited by 58 · see citing works

Mammalian Trit1 is a tRNA[Ser]Sec-isopentenyl transferase required for full selenoprotein expression

Fradejas‐Villar, N., Carlson, B. A., Rijntjes, E., Becker, N., Tobe, R., & Schweizer, U. (2013) · Biochemical Journal · doi:10.1042/bj20121713 · Cited by 52 · see citing works

Impact of PUFA on early immune and fetal development

Enke, U., Seyfarth, L., Schleußner, E., & Markert, U. R. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450801413x · Cited by 52 · see citing works

In vivo assessment of iron content of the cerebral cortex in healthy aging using 7-Tesla T2*-weighted phase imaging

Buijs, M., Doan, N. T., van Rooden, S., Versluis, M. J., van Lew, B., Milles, J., van der Grond, J., & van Buchem, M. A. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.09.005 · Cited by 50 · see citing works

Behavioral characterization of system xc- mutant mice

McCullagh, E. A., & Featherstone, D. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.010 · Cited by 41 · see citing works

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development

Haas, U., Raschperger, E., Hámberg, M., Samuelsson, B. O., Tryggvason, K., & Haeggström, J. Z. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117094108 · Cited by 33 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703 · see citing works

Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771 · see citing works

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654 · see citing works

Targeting Ferroptosis as a Vulnerability in Cancer

Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252 · see citing works

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Su, L.-J., Zhang, J.-H., Gomez, H., Murugan, R., Hong, X., Xu, D., Jiang, F., & Peng, Z.-Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5080843 · Cited by 2,166 · see citing works

NRF2 and the Hallmarks of Cancer

Rojo de la Vega, M., Chapman, E., & Zhang, D. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.022 · Cited by 1,672 · see citing works

Role of GPX4 in ferroptosis and its pharmacological implication

Seibt, T. M., Proneth, B., & Conrad, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.014 · Cited by 1,520 · see citing works

Ferroptosis: Mechanisms and links with diseases

Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471 · see citing works

13 reasons why the brain is susceptible to oxidative stress

Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

Wu, J., Minikes, A. M., Gao, M., Bian, H., Li, Y., Stockwell, B. R., Chen, Z.-N., & Jiang, X. (2019) · Nature · doi:10.1038/s41586-019-1426-6 · Cited by 1,110 · see citing works

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Zou, Y., Palte, M. J., Deik, A. A., Li, H., Eaton, J. K., Wang, W., Tseng, Y.-Y., Deasy, R., Kost-Alimova, M., Dančík, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09277-9 · Cited by 887 · see citing works

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Shah, R., Shchepinov, M. S., & Pratt, D. A. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00589 · Cited by 782 · see citing works

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Pajares, M., I. Rojo, A., Manda, G., Boscá, L., & Cuadrado, A. (2020) · Cells · doi:10.3390/cells9071687 · Cited by 779 · see citing works

The emerging role of ferroptosis in inflammation

Sun, Y., Chen, P., Zhai, B., Zhang, M., Xiang, Y., Fang, J., Xu, S., Gao, Y., Chen, X., Sui, X., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110108 · Cited by 739 · see citing works

Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects

Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724 · see citing works

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases

Park, M. W., Cha, H. W., Kim, J., Kim, J. H., Yang, H., Yoon, S., Boonpraman, N., Yi, S. S., Yoo, I. D., & Moon, J.-S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101947 · Cited by 683 · see citing works

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

Bai, B., Wang, X., Li, Y., Chen, P.-C., Yu, K., Dey, K. K., Yarbro, J. M., Han, X., Lutz, B. M., Rao, S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.015 · Cited by 632 · see citing works

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

Dai, E., Han, L., Liu, J., Xie, Y., Kroemer, G., Klionsky, D. J., Zeh, H. J., Kang, R., Wang, J., & Tang, D. (2020) · Autophagy · doi:10.1080/15548627.2020.1714209 · Cited by 613 · see citing works

Apoptosis and necroptosis in the liver: a matter of life and death

Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0065-y · Cited by 582 · see citing works

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Yoshida, M., Minagawa, S., Araya, J., Sakamoto, T., Hara, H., Tsubouchi, K., Hosaka, Y., Ichikawa, A., Saito, N., Kadota, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10991-7 · Cited by 572 · see citing works

p53 in ferroptosis regulation: The new weapon for the old guardian

Liu, Y., & Gu, W. (2022) · Cell Death & Differentiation · doi:10.1038/s41418-022-00943-y · Cited by 540 · see citing works

Regulation of lipid peroxidation and ferroptosis in diverse species

Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R. (2018) · Genes & Development · doi:10.1101/gad.314674.118 · Cited by 544 · see citing works

A major role for ferroptosis in <i>Mycobacterium tuberculosis</i> –induced cell death and tissue necrosis

Amaral, E. P., Costa, D. L., Namasivayam, S., Riteau, N., Kamenyeva, O., Mittereder, L., Mayer-Barber, K. D., Andrade, B. B., & Sher, A. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181776 · Cited by 464 · see citing works

Iron and Cancer

Torti, S. V., Manz, D. H., Paul, B. T., Blanchette-Farra, N., & Torti, F. M. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051732 · Cited by 426 · see citing works

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00862-0 · Cited by 414 · see citing works

The chemistry and biology of ferroptosis

Stockwell, B. R., & Jiang, X. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.013 · Cited by 429 · see citing works

The application of Ferroptosis in diseases

Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104919 · Cited by 415 · see citing works

The metabolic landscape of RAS-driven cancers from biology to therapy

Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer · doi:10.1038/s43018-021-00184-x · Cited by 315 · see citing works

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

Mukhopadhyay, S., Goswami, D., Adiseshaiah, P. P., Burgan, W., Yi, M., Guerin, T. M., Kozlov, S. V., Nissley, D. V., & McCormick, F. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-1363 · Cited by 279 · see citing works

NUPR1 is a critical repressor of ferroptosis

Liu, J., Song, X., Kuang, F., Zhang, Q., Xie, Y., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Communications · doi:10.1038/s41467-021-20904-2 · Cited by 290 · see citing works

Acetyl-CoA metabolism in cancer

Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00543-5 · Cited by 303 · see citing works

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

Mayr, L., Grabherr, F., Schwärzler, J., Reitmeier, I., Sommer, F., Gehmacher, T., Niederreiter, L., He, G.-W., Ruder, B., Kunz, K. T. R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15646-6 · Cited by 292 · see citing works

Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease

Wu, X., Fan, X., Miyata, T., Kim, A., Cajigas-Du Ross, C. K., Ray, S., Huang, E., Taiwo, M., Arya, R., Wu, J., et al. (2023) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-030435 · Cited by 289 · see citing works

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

Feng, L., Zhao, K., Sun, L., Yin, X., Zhang, J., Liu, C., & Li, B. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03042-7 · Cited by 277 · see citing works

Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review

Zhang, Y., Roh, Y. J., Han, S.-J., Park, I., Lee, H. M., Ok, Y. S., Lee, B. C., & Lee, S.-R. (2020) · Antioxidants · doi:10.3390/antiox9050383 · Cited by 267 · see citing works

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

Quiles del Rey, M., & Mancias, J. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00238 · Cited by 227 · see citing works

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron

Singhal, R., Mitta, S. R., Das, N. K., Kerk, S. A., Sajjakulnukit, P., Solanki, S., Andren, A., Kumar, R., Olive, K. P., Banerjee, R., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143691 · Cited by 215 · see citing works

Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11

Dong, H., Xia, Y., Jin, S., Xue, C., Wang, Y., Hu, R., & Jiang, H. (2021) · Cell Death &amp; Disease · doi:10.1038/s41419-021-04307-1 · Cited by 196 · see citing works

Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities

Miao, R., Fang, X., Zhang, Y., Wei, J., Zhang, Y., & Tian, J. (2023) · Cell Death &amp; Disease · doi:10.1038/s41419-023-05708-0 · Cited by 192 · see citing works

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

Birsen, R., Larrue, C., Decroocq, J., Johnson, N., Guiraud, N., Gotanegre, M., Cantero-Aguilar, L., Grignano, E., Huynh, T., Fontenay, M., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.259531 · Cited by 182 · see citing works

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

Trapecar, M., Wogram, E., Svoboda, D., Communal, C., Omer, A., Lungjangwa, T., Sphabmixay, P., Velazquez, J., Schneider, K., Wright, C. W., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd1707 · Cited by 176 · see citing works

Iron and the pathophysiology of diabetes

Harrison, A. V., Lorenzo, F. R., & McClain, D. A. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022522-102832 · Cited by 161 · see citing works

Iron: the cancer connection

Torti, S. V., & Torti, F. M. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100860 · Cited by 153 · see citing works

Ferroptosis at the crossroads of infection, aging and cancer

Toyokuni, S., Yanatori, I., Kong, Y., Zheng, H., Motooka, Y., & Jiang, L. (2020) · Cancer Science · doi:10.1111/cas.14496 · Cited by 142 · see citing works

Fundamental mechanisms of the cell death caused by Nitrosative stress

Wang, F., Yuan, Q., Chen, F., Pang, J., Pan, C., Xu, F., & Chen, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.742483 · Cited by 133 · see citing works

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability

Li, Z., Ferguson, L., Deol, K. K., Roberts, M. A., Magtanong, L., Hendricks, J. M., Mousa, G. A., Kilinc, S., Schaefer, K., Wells, J. A., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01033-3 · Cited by 134 · see citing works

p53 as a hub in cellular redox regulation and therapeutic target in cancer

Eriksson, S. E., Ceder, S., Bykov, V. J. N., & Wiman, K. G. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz005 · Cited by 123 · see citing works

Iron and innate antimicrobial immunity-depriving the pathogen, defending the host

Nairz, M., Dichtl, S., Schroll, A., Haschka, D., Tymoszuk, P., Theurl, I., & Weiss, G. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.03.007 · Cited by 123 · see citing works

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

Wang, Z., Zhang, X., Tian, X., Yang, Y., Ma, L., Wang, J., & Yu, Y. (2021) · Oncology Reports · doi:10.3892/or.2021.8039 · Cited by 122 · see citing works

Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs

Mastio, J., Condamine, T., Dominguez, G., Kossenkov, A. V., Donthireddy, L., Veglia, F., Lin, C., Wang, F., Fu, S., Zhou, J., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181952 · Cited by 115 · see citing works

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis

Wei, X.-B., Jiang, W.-Q., Zeng, J.-H., Huang, L.-Q., Ding, H.-G., Jing, Y.-W., Han, Y.-L., Li, Y.-C., & Chen, S.-L. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02738-1 · Cited by 123 · see citing works

Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects

Tong, B., Ba, Y., Li, Z., Yang, C., Su, K., Qi, H., Zhang, D., Liu, X., Wu, Y., Chen, Y., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106505 · Cited by 117 · see citing works

AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

Sun, H., Cai, H., Xu, C., Zhai, H., Lux, F., Xie, Y., Feng, L., Du, L., Liu, Y., Sun, X., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01654-9 · Cited by 86 · see citing works

Co-delivery of Dihydroartemisinin and Pyropheophorbide-Iron Elicits Ferroptosis to Potentiate Cancer Immunotherapy

Han, W., Duan, X., Ni, K., Li, Y., Chan, C., & Lin, W. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121315 · Cited by 103 · see citing works

Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

Toyokuni, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.401 · Cited by 102 · see citing works

Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations

Greenough, M. A., Lane, D. J. R., Balez, R., Anastacio, H. T. D., Zeng, Z., Ganio, K., McDevitt, C. A., Acevedo, K., Belaidi, A. A., Koistinaho, J., et al. (2022) · Cell Death &amp; Differentiation · doi:10.1038/s41418-022-01003-1 · Cited by 102 · see citing works

Simultaneous Fe ²⁺ /Fe ³⁺ imaging shows Fe ³⁺ over Fe ²⁺ enrichment in Alzheimer’s disease mouse brain

Wu, Y., Torabi, S.-F., Lake, R. J., Hong, S., Yu, Z., Wu, P., Yang, Z., Nelson, K., Guo, W., Pawel, G. T., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7622 · Cited by 91 · see citing works

RelB-activated GPX4 inhibits ferroptosis and confers tamoxifen resistance in breast cancer

Xu, Z., Wang, X., Sun, W., Xu, F., Kou, H., Hu, W., Zhang, Y., Jiang, Q., Tang, J., & Xu, Y. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102952 · Cited by 76 · see citing works

Glutathione: An Old and Small Molecule with Great Functions and New Applications in the Brain and in Alzheimer's Disease

Haddad, M., Hervé, V., Ben Khedher, M. R., Rabanel, J.-M., & Ramassamy, C. (2021) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2020.8129 · Cited by 68 · see citing works

Neurotrophic Role of the Next-Generation Probiotic Strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson’s Disease via Inhibiting Ferroptosis

Yue, M., Wei, J., Chen, W., Hong, D., Chen, T., & Fang, X. (2022) · Nutrients · doi:10.3390/nu14224886 · Cited by 62 · see citing works

Iron Pathophysiology in Alzheimer’s Diseases

Wang, T., Xu, S.-F., Fan, Y.-G., Li, L.-B., & Guo, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_5 · Cited by 64 · see citing works

The interplay of autophagy and non-apoptotic cell death pathways

(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.12.004 · Cited by 50 · see citing works

Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway

Yu, X., Wang, Y., Tan, J., Li, Y., Yang, P., Liu, X., Lai, J., Zhang, Y., Cai, L., Gu, Y., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01800-2 · Cited by 48 · see citing works

MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure

Wang, W., Shi, F., Cui, J., Pang, S., Zheng, G., & Zhang, Y. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113639 · Cited by 47 · see citing works

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium

Ito, F., Yanatori, I., Maeda, Y., Nimura, K., Ito, S., Hirayama, T., Nagasawa, H., Kohyama, N., Okazaki, Y., Akatsuka, S., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101616 · Cited by 45 · see citing works

Harnessing Ferroptosis to Overcome Drug Resistance in Colorectal Cancer: Promising Therapeutic Approaches

Cheng, X., Zhao, F., Ke, B., Chen, D., & Liu, F. (2023) · Cancers · doi:10.3390/cancers15215209 · Cited by 44 · see citing works

RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4

Wang, C., Chen, Z., Yi, Y., Ding, Y., Xu, F., Kang, H., Lin, K., Shu, X., Zhong, Z., Zhang, Z., et al. (2024) · Oncogene · doi:10.1038/s41388-023-02902-4 · Cited by 42 · see citing works

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2020) · doi:10.1101/2020.06.27.175679 · Cited by 414 · see citing works

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Ma, X., Dong, X., Xu, Y., Ma, N., Wei, M., Xie, X., Lu, Y., Cao, W., Lu, G., & Li, W. (2022) · Antioxidants · doi:10.3390/antiox12010100 · Cited by 41 · see citing works

Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions

Tan, X., Huang, X., Niu, B., Guo, X., Lei, X., & Qu, B. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1102158 · Cited by 40 · see citing works

Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats

Zhang, K., Long, M., Dong, W., Li, J., Wang, X., Liu, W., Huang, Q., Ping, Y., Zou, H., Song, R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020763 · Cited by 38 · see citing works

Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in <i>KRAS</i> -driven tumors

Jiang, H., Muir, R. K., Gonciarz, R. L., Olshen, A. B., Yeh, I., Hann, B. C., Zhao, N., Wang, Y.-H., Behr, S. C., Korkola, J. E., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20210739 · Cited by 33 · see citing works

HER2-Targeted Multifunctional Silica Nanoparticles Specifically Enhance the Radiosensitivity of HER2-Overexpressing Breast Cancer Cells

Yamaguchi, H., Hayama, K., Sasagawa, I., Okada, Y., Kawase, T., Tsubokawa, N., & Tsuchimochi, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030908 · Cited by 30 · see citing works

Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment

Kao, A. T., Cabanlong, C. V., Padilla, K., & Xue, X. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.025 · Cited by 30 · see citing works

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4

Liu, J.-P., Cen, S.-Y., Xue, Z., Wang, T.-X., Gao, Y., Zheng, J., Zhang, C., Hu, J., Nie, S., Xiong, Y., et al. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00445 · Cited by 29 · see citing works

Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis

Xu, C., Zhuo, Y., Liu, Y., & Chen, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.828983 · Cited by 23 · see citing works

Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences

Schiera, G., Macajone, G., Volpes, S., Greco, L., Di Liegro, C. M., Serio, G., Caradonna, F., & Naselli, F. (2026) · Cells · doi:10.3390/cells15040366 · Cited by 8 · see citing works

IMRC-exo alleviates limb injury by inhibiting ferroptosis in a rabbit model of deinagkistrodon acutus snakebite envenomation

Lai, L., Du, W., Wu, H., Liu, W., lv, K., Shangguan, P., Xie, L., Xu, J., & Lan, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-10746-z · Cited by 4 · see citing works

Snake venom-induced tissue damage as a paradigm of redox imbalance, ferroptosis, and inflammaging

Dahiya, R., Singh, A. P., & Rawat, A. (2026) · Toxicology Letters · doi:10.1016/j.toxlet.2026.111894 · Cited by 3 · see citing works

Methods and Trends for Water-Energy-Carbon Emissions Nexus Assessment

Wang, X., Klemeš, J. J., & Varbanov, P. S. (2021) · Chemical engineering transactions · doi:10.3303/cet2183025 · Cited by 1 · see citing works

Good practices & knowledge repository

(2019) · doi:10.18356/6556a659-en

Research progress on metabolic regulating cell fate

Cheng, J., Qian, D., & Ding, X. (2018) · Guoji shengwu yixue gongcheng zazhi · doi:10.3760/cma.j.issn.1673-4181.2018.04.009

Thermochemical studies on cell metabolism

Chang-Li, X., Day-Ung, S., Zhau-Hua, S., et al. (1990) · Thermochimica Acta · doi:10.1016/0040-6031(90)80066-8 · Cited by 7 · see citing works

Microcalorimetric studies on the metabolism of Chlorella vulgaris

Yi, L., Tahn, T. T., Zhong, C., et al. (2000) · Chemosphere · doi:10.1016/s0045-6535(99)00299-4 · Cited by 15 · see citing works