Lucet, Isabelle S.

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,220

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 598

The molecular basis of JAK/STAT inhibition by SOCS1

Liau, N. P. D., Laktyushin, A., Lucet, I. S., Murphy, J. M., Yao, S., Whitlock, E., Callaghan, K., Nicola, N. A., Kershaw, N. J., & Babon, J. J. (2018) · Nature Communications

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 456

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 301

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S., & Nicola, N. A. (2012) · Immunity

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 279

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

Jacobsen, A. V., Lowes, K. N., Tanzer, M. C., Lucet, I. S., Hildebrand, J. M., Petrie, E. J., van Delft, M. F., Liu, Z., Conos, S. A., Zhang, J.-G., et al. (2016) · Cell Death & Disease

Cell death mechanisms and regulationHeat shock proteins research

Cited by 160

When two’s a crowd - Structural mapping of PEAK pseudokinase interactions identifies 14 3 3 as a molecular switch for PEAK3/Crk signaling.

Lucet, I., Roy, M., Surudoi, M., Kropp, A., Hou, J., Dai, W., Hardy, J., Liang, L.-Y., Cotton, T., Lechtenberg, B., et al. (2022) · Nature Communications

14-3-3 protein interactionsProtein Kinase Regulation and GTPase Signaling

Cited by 16

ProteinDJ : A high‐performance and modular protein design pipeline

Silke, D., Iskander, J., Pan, J., Thompson, A. P., Papenfuss, A. T., Lucet, I. S., & Hardy, J. M. (2026) · Protein Science

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 6