Hutchison, Clyde A.

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

Gibson, D. G., Glass, J. I., Lartigue, C., Noskov, V. N., Chuang, R.-Y., Algire, M. A., Benders, G. A., Montague, M. G., Ma, L., Moodie, M. M., et al. (2010) · Science

Microbial Metabolic Engineering and BioproductionRNA and protein synthesis mechanisms

Cited by 2,638

The Minimal Gene Complement of Mycoplasma genitalium

Fraser, C. M., Gocayne, J. D., White, O., Adams, M. D., Clayton, R. A., Fleischmann, R. D., Bult, C. J., Kerlavage, A. R., Sutton, G., Kelley, J. M., et al. (1995) · Science

Microbial infections and disease researchGenomics and Phylogenetic Studies

Cited by 2,545

Design and synthesis of a minimal bacterial genome

Hutchison, C. A., Chuang, R.-Y., Noskov, V. N., Assad-Garcia, N., Deerinck, T. J., Ellisman, M. H., Gill, J., Kannan, K., Karas, B. J., Ma, L., et al. (2016) · Science

Microbial Metabolic Engineering and BioproductionRNA and protein synthesis mechanisms

Cited by 1,500

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

Gibson, D. G., Benders, G. A., Andrews-Pfannkoch, C., Denisova, E. A., Baden-Tillson, H., Zaveri, J., Stockwell, T. B., Brownley, A., Thomas, D. W., Algire, M. A., et al. (2008) · Science

CRISPR and Genetic EngineeringMicrobial infections and disease research

Cited by 1,243

Essential genes of a minimal bacterium

Glass, J. I., Assad-Garcia, N., Alperovich, N., Yooseph, S., Lewis, M. R., Maruf, M., Hutchison, C. A., Smith, H. O., & Venter, J. C. (2006) · Proceedings of the National Academy of Sciences

Bacterial Genetics and BiotechnologyMicrobial infections and disease research

Cited by 912

E-CELL: software environment for whole-cell simulation

Tomita, M., Hashimoto, K., Takahashi, K., Shimizu, T. S., Matsuzaki, Y., Miyoshi, F., Saito, K., Tanida, S., Yugi, K., Venter, J. C., et al. (1999) · Bioinformatics

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 764

Complete mutagenesis of the HIV-1 protease

Loeb, D. D., Swanstrom, R., Everitt, L., Manchester, M., Stamper, S. E., & Hutchison, C. A. (1989) · Nature

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 327

Essential metabolism for a minimal cell

Breuer, M., Earnest, E. E., Merryman, C., Wise, K. S., Sun, L., Lynott, M. R., Hutchison, C. A., Smith, H. O., Lapek, J. D., Gonzalez, D. J., et al. (2019) · eLife

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 190

Fundamental behaviors emerge from simulations of a living minimal cell

Thornburg, Z. R., Bianchi, D. M., Brier, T. A., Gilbert, B. R., Earnest, E. E., Melo, M. C. R., Safronova, N., Sáenz, J. P., Cook, A. T., Wise, K. S., et al. (2022) · Cell

Lipid Membrane Structure and BehaviorLipid metabolism and biosynthesis

Cited by 165

Evolution of the mammalian beta-globin gene cluster.

Hardies, S. C., Edgell, M. H., & Hutchison, C. A. (1984) · Journal of Biological Chemistry

Hemoglobin structure and functionChromosomal and Genetic Variations

Cited by 78

Transcriptional Analysis of the Conserved ftsZ Gene Cluster in Mycoplasma genitalium and Mycoplasma pneumoniae

Benders, G. A., Powell, B. C., & Hutchison, C. A. (2005) · Journal of Bacteriology

Bacterial Genetics and BiotechnologyMicrobial infections and disease research

Cited by 34

Kinetic modeling of the genetic information processes in a minimal cell

Thornburg, Z. R., Melo, M. C. R., Bianchi, D., Brier, T. A., Crotty, C., Breuer, M., Smith, H. O., Hutchison, C. A., Glass, J. I., & Luthey-Schulten, Z. (2019) · Frontiers in Molecular Biosciences

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 22

Toward the Complete Functional Characterization of a Minimal Bacterial Proteome

Bianchi, D. M., Pelletier, J. F., Hutchison, C. A., Glass, J. I., & Luthey-Schulten, Z. (2022) · The Journal of Physical Chemistry B

Microbial Metabolic Engineering and BioproductionProtein Structure and Dynamics

Cited by 22