Vandenberghe, Luk H.

Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

Gao, G., Vandenberghe, L. H., Alvira, M. R., Lu, Y., Calcedo, R., Zhou, X., & Wilson, J. M. (2004) · Journal of Virology

Virus-based gene therapy researchParvovirus B19 Infection Studies

Cited by 1,070

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

Tabebordbar, M., Zhu, K., Cheng, J. K. W., Chew, W. L., Widrick, J. J., Yan, W. X., Maesner, C., Wu, E. Y., Xiao, R., Ran, F. A., et al. (2016) · Science

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 1,046

Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses

Calcedo, R., Vandenberghe, L. H., Gao, G., Lin, J., & Wilson, J. M. (2009) · The Journal of Infectious Diseases

Virus-based gene therapy researchVirology and Viral Diseases

Cited by 808

New recombinant serotypes of AAV vectors

Gao, G., Vandenberghe, L., & Wilson, J. (2005) · Current Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 487

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

Landegger, L. D., Pan, B., Askew, C., Wassmer, S. J., Gluck, S. D., Galvin, A., Taylor, R., Forge, A., Stankovic, K. M., Holt, J. R., et al. (2017) · Nature Biotechnology

Virus-based gene therapy researchHearing, Cochlea, Tinnitus, Genetics

Cited by 325

In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

Zinn, E., Pacouret, S., Khaychuk, V., Turunen, H. T., Carvalho, L. S., Andres-Mateos, E., Shah, S., Shelke, R., Maurer, A. C., Plovie, E., et al. (2015) · Cell Reports

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 310

Comparative Analysis of Adeno-Associated Viral Vector Serotypes 1, 2, 5, 7, And 8 in Mouse Brain

Taymans, J.-M., Vandenberghe, L. H., Haute, C. V. D., Thiry, I., Deroose, C. M., Mortelmans, L., Wilson, J. M., Debyser, Z., & Baekelandt, V. (2007) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 305

Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors

Allocca, M., Mussolino, C., Garcia-Hoyos, M., Sanges, D., Iodice, C., Petrillo, M., Vandenberghe, L. H., Wilson, J. M., Marigo, V., Surace, E. M., et al. (2007) · Journal of Virology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 246

Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey

Vandenberghe, L. H., Bell, P., Maguire, A. M., Cearley, C. N., Xiao, R., Calcedo, R., Wang, L., Castle, M. J., Maguire, A. C., Grant, R., et al. (2011) · Science Translational Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 242

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

Breous, E., Somanathan, S., Vandenberghe, L. H., & Wilson, J. M. (2009) · Hepatology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 237

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

Vandenberghe, L. H., Wang, L., Somanathan, S., Zhi, Y., Figueredo, J., Calcedo, R., Sanmiguel, J., Desai, R. A., Chen, C. S., Johnston, J., et al. (2006) · Nature Medicine

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 208

The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice

Bell, C. L., Vandenberghe, L. H., Bell, P., Limberis, M. P., Gao, G.-P., Van Vliet, K., Agbandje-McKenna, M., & Wilson, J. M. (2011) · Journal of Clinical Investigation

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 190

Expanded Repertoire of AAV Vector Serotypes Mediate Unique Patterns of Transduction in Mouse Brain

Cearley, C. N., Vandenberghe, L. H., Parente, M. K., Carnish, E. R., Wilson, J. M., & Wolfe, J. H. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 182

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

Wassmer, S. J., Carvalho, L. S., György, B., Vandenberghe, L. H., & Maguire, C. A. (2017) · Scientific Reports

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 164

Tailoring the AAV vector capsid for gene therapy

Vandenberghe, L. H., Wilson, J. M., & Gao, G. (2009) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 155

Efficient Serotype-Dependent Release of Functional Vector into the Culture Medium During Adeno-Associated Virus Manufacturing

Vandenberghe, L. H., Xiao, R., Lock, M., Lin, J., Korn, M., & Wilson, J. M. (2010) · Human Gene Therapy

Virus-based gene therapy researchViral Infectious Diseases and Gene Expression in Insects

Cited by 151

Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids

Castle, M. J., Turunen, H. T., Vandenberghe, L. H., & Wolfe, J. H. (2016) · Methods in Molecular Biology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 151

Genome Editing Abrogates Angiogenesis in Vivo

Huang, X., Zhou, G., Wu, W., Duan, Y., Ma, G., Song, J., Xiao, R., Vandenberghe, L., Zhang, F., D’Amore, P. A., et al. (2017) · Nature Communications

CRISPR and Genetic EngineeringAngiogenesis and VEGF in Cancer

Cited by 142

Novel adeno-associated viral vectors for retinal gene therapy.

Vandenberghe, L. H., & Auricchio, A. (2012) · Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 131

The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques

Wang, L., Calcedo, R., Wang, H., Bell, P., Grant, R., Vandenberghe, L. H., Sanmiguel, J., Morizono, H., Batshaw, M. L., & Wilson, J. M. (2010) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 130

AAV9 targets cone photoreceptors in the nonhuman primate retina

Vandenberghe, L. H., Bell, P., Maguire, A. M., Xiao, R., Hopkins, T. B., Grant, R., Bennett, J., & Wilson, J. M. (2013) · PLoS ONE

Retinal Development and DisordersVirus-based gene therapy research

Cited by 97

Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting

Carvalho, L. S., Turunen, H. T., Wassmer, S. J., Luna-Velez, M. V., Xiao, R., Bennett, J., & Vandenberghe, L. H. (2017) · Frontiers in Neuroscience

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 86

Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65

Hudry, E., Andres-Mateos, E., Lerner, E. P., Volak, A., Cohen, O., Hyman, B. T., Maguire, C. A., & Vandenberghe, L. H. (2018) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 84

Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality

Hudry, E., & Vandenberghe, L. H. (2019) · Neuron

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 77