Hooper, Steven

Mutations of the BRAF gene in human cancer

Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 10,674

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 1,589

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology

Hippo pathway signaling and YAP/TAZCellular Mechanics and Interactions

Cited by 1,478

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

Hirata, E., Girotti, M. R., Viros, A., Hooper, S., Spencer-Dene, B., Matsuda, M., Larkin, J., Marais, R., & Sahai, E. (2015) · Cancer Cell

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 593

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

Sanz-Moreno, V., Gaggioli, C., Yeo, M., Albrengues, J., Wallberg, F., Viros, A., Hooper, S., Mitter, R., Féral, C. C., Cook, M., et al. (2011) · Cancer Cell

Cellular Mechanics and InteractionsCytokine Signaling Pathways and Interactions

Cited by 409

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Calvo, F., Ranftl, R., Hooper, S., Farrugia, A. J., Moeendarbary, E., Bruckbauer, A., Batista, F., Charras, G., & Sahai, E. (2015) · Cell Reports

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 142

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Kondo, H., Ratcliffe, C. D. H., Hooper, S., Ellis, J., MacRae, J. I., Hennequart, M., Dunsby, C. W., Anderson, K. I., & Sahai, E. (2021) · Cell Reports

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 109

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

Arwert, E. N., Milford, E. L., Rullan, A., Derzsi, S., Hooper, S., Kato, T., Mansfield, D., Melcher, A., Harrington, K. J., & Sahai, E. (2020) · Nature Cell Biology

interferon and immune responsesVirus-based gene therapy research

Cited by 90

A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion

Hooper, S., Gaggioli, C., & Sahai, E. (2010) · British Journal of Cancer

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 80

Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

Sparks, H., Kondo, H., Hooper, S., Munro, I., Kennedy, G., Dunsby, C., French, P., & Sahai, E. (2018) · Nature Communications

Advanced Fluorescence Microscopy TechniquesOptical Imaging and Spectroscopy Techniques

Cited by 54

Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts

Chaudhry, S. I., Hooper, S., Nye, E., Williamson, P., Harrington, K., & Sahai, E. (2013) · Oncogene

NF-κB Signaling PathwaysTGF-β signaling in diseases

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