Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

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3D imaging for driving cancer discovery

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Recent advancements in single-cell metabolic analysis for pharmacological research

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Metabolic dependencies of metastasis-initiating cells in female breast cancer

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Metabolic landscape of disseminated cancer dormancy

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Reciprocal regulation of actin filaments and cellular metabolism

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Metabolic crosstalk between stromal and malignant cells in the bone marrow niche

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Development and validation of an intra-tumor heterogeneity-related signature to predict prognosis of bladder cancer: a study based on single-cell RNA-seq

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Label-free metabolic imaging for sensitive and robust monitoring of anti-CD47 immunotherapy response in triple-negative breast cancer

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The Role of Metabolism in Tumor Immune Evasion: Novel Approaches to Improve Immunotherapy

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The role of glycometabolic plasticity in cancer

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Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes

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Spatially resolved analysis of microenvironmental gradient impact on cancer cell phenotypes

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Spatiotemporal Heterogeneity of Tumor Glucose Metabolism Reprogramming: From Single-Cell Mechanisms to Precision Interventions

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SPICE‐Met: profiling and imaging energy metabolism at the single‐cell level using a fluorescent reporter mouse

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High extracellular glucose promotes cell motility by modulating cell deformability and contractility via the cAMP-RhoA-ROCK axis in human breast cancer cells

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Macrophages play a role in inflammatory transformation of colorectal cancer

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Bone Marrow Mesenchymal Stem Cells Induce Metabolic Plasticity in Estrogen Receptor–Positive Breast Cancer

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Quantum dots based in-vitro co-culture cancer model for identification of rare cancer cell heterogeneity

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Intracellular kynurenine promotes acetaldehyde accumulation, further inducing the apoptosis in soil beneficial fungi Trichoderma guizhouense NJAU4742 under acid stress

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Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors

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Electroacupuncture protective effects after cerebral ischemia are mediated through miR-219a inhibition

Dai, Y., Wang, S., Yang, M.-G., Zhuo, P.-Y., Ding, Y., Li, X., Cao, Y., Guo, X.-Q., Lin, H., Tao, J., et al. (2023) · Biological Research · doi:10.1186/s40659-023-00448-z · Cited by 13 · see citing works

Impact of ionizing radiation on cell-ECM mechanical crosstalk in breast cancer

Mottareale, R., Frascogna, C., Verde, G. L., Arrichiello, C., Muto, P., Netti, P. A., Fusco, S., Panzetta, V., & Pugliese, M. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1408789 · Cited by 13 · see citing works

Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations

Abecunas, C., Kidd, A. D., Jiang, Y., Zong, H., & Fallahi‐Sichani, M. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114775 · Cited by 12 · see citing works

Fast autofluorescence imaging to evaluate dynamic changes in cell metabolism

Theodossiou, A. M., Martinez, J., & Walsh, A. J. (2024) · Journal of Biomedical Optics · doi:10.1117/1.jbo.29.12.126501 · Cited by 12 · see citing works

Vitamin B2 Prevents Glucocorticoid‐Caused Damage of Blood Vessels in Osteonecrosis of the Femoral Head

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Breast cancers as ecosystems: a metabolic perspective

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Recent advances in the investigation of the regulatory network underlying reactive nitrogen species-mediated tumorigenesis: molecular mechanisms and targeted therapeutic strategies

Wu, Y., Chen, Z., Chen, X., Hu, Y., & Ma, Y. (2025) · Redox Report · doi:10.1080/13510002.2025.2564593 · Cited by 11 · see citing works

Optoelectronic Properties and Fluorescence Lifetime Imaging Application of Donor‐Acceptor Dyads Derived From 2,6‐DicarboxyBODIPY

Sheehan, A., Okkelman, I. A., Groslambert, G., Bucher, C., Dmitriev, R. I., & Filatov, M. A. (2024) · Chemistry - A European Journal · doi:10.1002/chem.202404188 · Cited by 11 · see citing works

Ultra-thin temperature controllable microwell array chip for continuous real-time high-resolution imaging of living single cells

Wu, Y., Zhao, L. Q., Chang, Y., Zhao, L., Guo, G., & Wang, X. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.05.034 · Cited by 11 · see citing works

Quantifying and visualising the nuances of cellular dynamics in vivo using intravital imaging

Murphy, K. J., Reed, D. A., Trpceski, M., Herrmann, D., & Timpson, P. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.04.007 · Cited by 11 · see citing works

Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays

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Longitudinal FRET Imaging of Glucose and Lactate Dynamics and Response to Therapy in Breast Cancer Cells

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Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells

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Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time

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When Mechanical Stress Matters: Generation of Polyploid Giant Cancer Cells in Tumor‐Like Microcapsules

Antonelli, Y., Krüger, R., Büehler, A., Monavari, M., Fuentes‐Chandía, M., Colombo, F., Palmisano, R., Bosserhoff, A., Kappelmann‐Fenzl, M., Schödel, J., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202311139 · Cited by 9 · see citing works

Navigating Nongenetic Plasticity in Cancer Drug Resistance

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E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence

Avenhaus, A., Velimirović, M., Bulkescher, J., Scheffner, M., Hoppe‐Seyler, F., & Hoppe‐Seyler, K. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012914 · Cited by 9 · see citing works

Coexistence of “Cream Skimmer” and “Crumb Picker” Phenotypes in Nature and in Cancer

Huntly, N. J., Freischel, A. R., Miller, A., Lloyd, M. C., Basanta, D., & Brown, J. S. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.697618 · Cited by 8 · see citing works

Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma

Ye, Y., & Cao, Z. (2024) · Cancer Investigation · doi:10.1080/07357907.2024.2407424 · Cited by 7 · see citing works

Bioimaging approaches for quantification of individual cell behavior during cell fate decisions

Begnini, K. R., Pereira, L. C., Faccioni, J. L., Lenz, G., & Filippi‐Chiela, E. C. (2022) · Biochemical Society Transactions · doi:10.1042/bst20210534 · Cited by 7 · see citing works

Tumor heterogeneity and the dilemma of antioxidant therapies in cancer

Selistre-de-Araújo, H. S., Pachane, B. C., & Altei, W. F. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-4219 · Cited by 7 · see citing works

Asymmetric cell division of ALDH1-positive cancer stem cells generates glycolytic metabolically diverse cell populations

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An mTurquoise2-Based Glucose Biosensor

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Methods and Guidelines for Metabolism Studies: Applications to Cancer Research

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BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity

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MGAT4EP promotes tumor progression and serves as a prognostic marker for breast cancer

Zhong, L., Zhu, J., Chen, J., Jin, X., Liu, L., Ji, S., Luo, J., & Wang, H. (2025) · Cancer Biology & Therapy · doi:10.1080/15384047.2025.2475604 · Cited by 5 · see citing works

Technologies for Decoding Cancer Metabolism with Spatial ResolutionPreprint

Chen, W. W., Pacold, M. E., Sabatini, D. M., & Kanarek, N. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041553 · Cited by 5 · see citing works

Understanding metabolic plasticity at single cell resolution

Abbate, C. C., Hu, J., & Albeck, J. G. (2024) · Essays in Biochemistry · doi:10.1042/ebc20240002 · Cited by 4 · see citing works

Intravital Microscopy Techniques to Image Wound Healing in Mouse Skin

Turk, M., Biernaskie, J. A., Mahoney, D. J., & Jenne, C. N. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2051-9_10 · Cited by 4 · see citing works

PCSK9 and APOA4 : The Dynamic Duo in TMAO-induced Cholesterol Metabolism and Cholelithiasis

Shi, C., Yu, J., Meng, Z., Lu, D.-Y., Ding, H., Sun, H., Shi, G., Xue, D., & Meng, X. (2025) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2024.00403 · Cited by 3 · see citing works

Fructose-1,6-bisphosphate couples glycolytic activity to cell adhesion

Hoffmann, L., Duchmann, M., Lazarow, K., Huang, Y.-H., Lukas, F., Lo, W., Feil, R., Schmied, C., Lehmann, M., Lunn, J. E., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01911-1 · Cited by 4 · see citing works

Glycolysis and Gluconeogenesis

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FIBP is a prognostic biomarker and correlated with clinicalpathological characteristics and immune infiltrates in acute myeloid leukemia

Ma, M., Xu, L., Cui, W., Huang, Y. Y., & Chi, G. (2023) · Discover Oncology · doi:10.1007/s12672-023-00723-1 · Cited by 3 · see citing works

When Mechanical Stress Matters: Generation of Polyploid Giant Cancer Cells in Tumor-like MicrocapsulesPreprint

Büehler, A., Krüger, R., Monavari, M., Fuentes‐Chandía, M., Palmisano, R., Schödel, J., Boccaccini, A. R., Bosserhoff, A., Kappelmann‐Fenzl, M., Letort, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.22.508846 · Cited by 3 · see citing works

Heterogeneity of glucose metabolism and uptake identifies distinct cancer cell and cancer stem cell phenotypes

Tylichová, Z., Krkoška, M., Hrabal, V., Stenckova, M., Vojtěšek, B., & Coates, P. J. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00837-0 · Cited by 2 · see citing works

Luminescence Lifetime Imaging: Key Concepts and Advances in the Image Acquisition, Processing, and Analysis Pipeline

Harkhoe, R., Ferrari, G., Dmitriev, R. I., & Kühl, M. (2026) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.5c00209 · Cited by 2 · see citing works

Monitoring Cellular Energy Balance in Single Cells Using Fluorescent Biosensors for AMPK

DeCuzzi, N. L., Kosaisawe, N., Pargett, M., Cabel, M., & Albeck, J. G. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4284-9_3 · Cited by 2 · see citing works

Multicolor fluorescence biosensors reveal a burning need for diversity in the single-cell metabolic landscape

Islam, M. T., Holland, W. L., & Lesniewski, L. A. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.04.002 · Cited by 2 · see citing works

Proteomic landscape of multi-layered breast cancer internal tumor heterogeneityPreprint

Mardamshina, M., Shenoy, A., Necula, D., Krol, K., Pirak, D., Itzhacky, N., Marin, I., Shalmon, B., Sharan, R., Gal-Yam, E., et al. (2021) · bioRxiv · doi:10.1101/2021.08.05.455361 · Cited by 1 · see citing works

Two Novel Red-FRET ERK Biosensors in the 670-720nm RangePreprint

DeCuzzi, N. L., Hu, J. J., Xu, F., Rodriguez, B., Pargett, M., & Albeck, J. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.30.626109 · Cited by 2 · see citing works

Evolution-Informed Modeling and Control of Tumor Growth

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Two novel red-FRET ERK Biosensors in the 670-720 nm range

DeCuzzi, N. L., Hu, J. J., Xu, F., Rodriguez, B., Pargett, M., & Albeck, J. G. (2025) · Journal of Biological Engineering · doi:10.1186/s13036-025-00541-9 · Cited by 1 · see citing works

Mitochondrial Metabolism in Breast Cancer

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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

Floerchinger, A., Murphy, K. J., Latham, S. L., Warren, S. C., McCulloch, A. T., Lee, Y. K., Stoehr, J., Mélénec, P., S.Guaman, C., Metcalf, X. L., et al. (2023) · doi:10.32920/21985085 · Cited by 1 · see citing works

deepthought: the microscopy acquisition stack as an object of studyPreprint

Kesavan, P. S., Devadasan, S., & Bohra, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.25.639997 · Cited by 1 · see citing works

Imaging heterogeneous glucose metabolism during tumour proliferation and migration

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Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells

Blaszczak, W., White, B., Monterisi, S., & Swietach, P. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113612 · Cited by 9 · see citing works

Abstract 1274: Investigation into the influence of the H1047R PIK3CA mutation on the bioenergetic dependency of a cell

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Abstract 5239: Unraveling the complex regulatory relationship between PI3K signaling and metabolic transformation in breast cancer.

Wynn, M. L., Egbert, M. E., Wassenhove, L. D. V., Wu, Z.-F., Midani, F. S., Evans, C. R., Burant, C., Schnell, S. D., & Merajver, S. D. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-5239

Single-Cell FISH Analysis Reveals Distinct Shifts in PKM Isoform Populations during Drug Resistance Acquisition

Kim, S. H., Wi, J. H., Gwak, H., Yang, E. G., & Kim, S. Y. (2022) · Biomolecules · doi:10.3390/biom12081082 · Cited by 3 · see citing works